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《Journal of Dalian Polytechnic University》 2008-04
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Antitumor and immunomodulating activity in vitro of the polysaccharide from Haliotis Discus Hannai Ino

WANG Li-sha,ZHU Bei-wei,SUN Li-ming,LI Dong-mei School of Biological & Food Engineering,Dalian Polytechnic University,Dalian 116034,China  
The polysaccharides AVP Ⅰ and AVP Ⅱ are extracted from the viscera of Haliotis Discus Hannai Ino and separated on Sephadex G-100 column.The polysaccharide contents of AVP Ⅰ and AVP Ⅱ are 66.41% and 51.84%,and the protein contents are 1.70% and 15.55% respectively.The molecular masses of AVP Ⅰ and AVP Ⅱ are 272 and 6 ku.AVP Ⅰ and AVP Ⅱ contain the same monosaccharide including rhamnose,glucose,xylose,mannose,galactose and fucose,the ratio of which for AVP Ⅰ is 1.00∶2.15∶4.00∶5.36∶33.18∶45.14,whereas AVP Ⅱ is 1.00∶1.46∶1.33∶4.98∶16.08∶12.51.AVP Ⅰ and AVP Ⅱ could restrain the proliferation of Hela and K562 cell in vitro.AVP Ⅰ and AVP Ⅱ can dose-dependently induce a significant increase in lymphocyte proliferation,phagocytosis of macrophage and natural killer cell activity in vitro.The abalone viscera can be used potentially as an immuneomodulating agent.
【Fund】: 国家国际科技合作重大项目(2006DFA32580);; 国家高技术研究发展计划项目(863计划)(2007AA091804)
【CateGory Index】: R151
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