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Protective Effect of Aleppo Avens on Mouse Cerebral Ischemia

LAI Yong,LI Hui,FANG Chun-sheng,LIU Xiao-bo,YANG Zai-kang(Department of Pharmacology,Dali University,Dali,Yunnan 671000,China)  
Objective: To observe the protective effects of Aleppo avens on mouse cerebral ischemia.Methods: Hemi arteria carotid and vagus nerve is imperfectly ligated,other side is completely ligated,then observe 12h's survival time and death rate.Results: To compare with the normal saline control group,Aleppo avens 12?24?48g/kg ig can prolong survival time,prolonged rates are 45%(P0.01)199%(P0.05)? 206%(P0.01)respectively;depress death rate,declining 6.8%(P0.01),46%(P0.05) and 57%(P0.01) respectively,All results assume definite dose-effect correlation tendency.Otherwide,Aleppo avens's 12?24 and 48k/kg ig can increase mouse tolerance to experimental oxygen deficit.Conclusion: Aleppo avens have protective effect to mouse cerebral ischemia.
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