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《Journal of Dali University》 2008-12
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Research on Genotypes and Subgenotypes of HBV Infection among Drug Abusers in Dali

SHEN Yuanying1,WANG Tao1,REN Laifeng2,LI Wei1,ZHANG Xuanrong1(1.Department of Microbiology & Immunology,Dali University,Dali,Yunnan 671000,China;2.Department of Microbiology & Immunology,Fenyang College of Shanxi Medical University,Fenyang,Shanxi 032200,China)  
Objective: To investigate the infection of hepatitis B virus genotypes and subtypes identification among drug abusers in Dali.Methods: 192 drug abusers were enrolled from a drug rehabilitation center in Dali.The HBV markers(HBVM),including HBsAg,HBsAb,HBeAg,HBeAb and HBcAb,were tested with ELISA;HBV genotypes and subgenotypes were determined by PCR and PCR-RLFP with specific primers respectively.Results: Among 192 drug abusers,HBsAg positive rate was 8.85%(17/192).Among 17 HBsAg positive drug abusers,genotype B,C and B +C were 3,1,3 respectively.All subgenotype B was Ba.All subgenotype C was Cs.Conclusion: There was high prevalence of HBV among drug abusers in Dali,and furthermore there were genotype B,C and B+C,among which Ba and Cs were dominant sub-genotypes.
【Fund】: 国家自然科学基金资助项目(30560136);; 云南省中青年学术技术带头人后备人才培养基金资助项目(2006py057);; 大理市科学技术局科学研究基金资助项目(2006SF10)
【CateGory Index】: R512.6
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