THE PROTECTIVE EFFECTS OF GENTIOPICROSIDE ON MICE INTOXICATED BY CCI_4 AND ACETAMINOPHEN
Lin Yuan Department of Pharmacology,Dalian Medical College
Gentiopicroside (GP) significantly reduced mice mortality given both before/after and before intoxication of CCl_4. In the way, GP also apparently raise LD_(50) of CCl_4. The LD_(50) of CCl_4 control is 1222mg/kg, and the LD_(50) of GP treated both before/after and before intoxication of CCl_4 are 1775mg/kg and 1610mg/kg respectively. The effect of GP treated after intoxication of CCl_4 is not obvious. GP also signgicently reduced mice mortality given before the intoxication of acetaminophen.