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《Journal of Dalian Medical University》 2002-01
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Clinical observation of prevention of morphine's adverse effect during epidural analgesia by ondansetron combined with nalo-xone

LAN Zhong-yue, YUE Jun, JIANG Xiao-fen,HU Ming-Lun (Department of Anesthesiology, the First Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000,China)  
Objective: We have observed the clinical effect of ondan-setron combined with naloxone on preventing the adverse effect of epidural morphine analgesia. Methods: Eight gynecological patients scheduled for selective operation were assigned into four groups: group I (the control group, no ondansetron and naloxone), group II (ondansetron group), group III (naloxone group), group IV (ondansetron combined with naloxone group). We used epidural morphine analgesia on all patients after operation. In group II and IV, we used 8 mg ondansetron intravenously after operation, in group III and IV we used 0.4 mg naloxone additionally. Results: All patients of four groups have no significant difference in analgesic effect. Compared with group I, patients of group II ,III and IV had significantly reduced postoperative nausea , vomiting, and itch of skin(P0.05),while among group IV , group II and III there was no significant difference.Compared with the other two groups, patients of group III and IV had lower morbidity of urinal retention (P0.01). Conclusions: Ondansetron combined with naloxone could control the adverse effect effectively, while no effect on analgesic effect.
【CateGory Index】: R614
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 Chen Shaoyang,Zhu Xiaoling,Hu Sheng,et al.*"Departerment of Anesthesiology,Xijing Hospital,Fourth Military Medical University,Xi'an 710032 CHINA;A comparison of the prophylactic antiemetic effect of metoclopramide,ondanesetron and navoban during PCA[J];The Journal of Clinical Anesthesilolgy;2001-05
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 Department of Anesthesiology,the Second People's Hospital of WuHu,WuHu 241000,Anhui CUI Wen,ZHANG Qi,FANG Ming-xing;Observation of SLIPA larygneal mask used for the operation on the fracture of upper limb in the aged patients[J];Journal of Anhui Health Vocational & Technical College;2010-05
2 PENG Yong-ming,HUANG Ling,ZHOU Nan-zheng (Department of Anesthesiology ,Shenzhen Xili Pelople's Hospital,Shenzhen 518055, China);Comparison of application with intravenous propofol injection and nitrous oxide inhalation on abortion analgesia[J];Anhui Medical and Pharmaceutical Journal;2005-06
3 ZHANG He-tian, ZHENG Yan,SHAN Xue-mei,WANG Tan-yuan (Department of Anesthesiology, China-Japan Union Hospital, Jilin University,Changchun 130031,China);Effects of Midazolam on preventing patients from awareness and reviving in different time with intravenous injection[J];Journal of Jilin University of (Medicine Edition);2005-04
4 CUI Hujun 1△ , ZHANG Mingli 1, XIAO Feng 1, LI Yan 1,WANG Jin 1, CHEN Hongyi 2 (1. Department of Cardiac surgery, 2. Department of Thoracic surgery, Peking University First Hospital, Beijing 100034, China);Comparison and correlative analysis of pulmonary function markers after extracorporeal circulation[J];Journal of Beijing Medical University;2003-02
5 SHU Yun-bing1,SUN Guang-yun1,YANG Xiao-hui2,ZHOU Li-ping1,YAO Hong-lin3(1 The First People's Hospital of Yibin,Yibin 644000,China;2 The Third People's Hospital of Yibin,Yibin,Sichuan 644000,China;3 The Second People's Hospital of Yibin,Yibin,Sichuan 644000,China);Application of ANH combined with CH in spinal operation[J];Journal of Chengdu Medical College;2011-01
6 CAI Jian (Department of Anesthesiology,Taicang Traditional Chinese Medical Hospital,Jiangsu Taicang 215400,China);CLINICAL OBSERVATION ON ONDANSETRON IN PREVENTING ADVERSE EFFECTS OF MORPHINE ANALGESIA IN SPINAL CANAL[J];Journal of Chengde Medical College;2008-04
7 YANG Lian-wei, ZHOU Bai-jing, LI Cheng-gang (Hospital Affiliated to Dalian University,Dalian 116021,China);Observation about the clinical effects of different anesthesia in artificial abortion[J];Journal of Dalian University;2004-02
8 Ma Cong,Luo Qingyu,Zhuo Qinglan,et al People's Hospital of Nanshan,Shenzhen 518052,Guangdong,P R China;Effect Observation and Nursing on Two way of Patient-controlled Analgesia Used on Postoperative Patients with Skeletal Disease[J];;2003-08
9 ;硬膜外麻醉分娩镇痛临床观察[J];Contemporary Medicine;2009-07
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