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《Journal of Dalian Medical University》 2002-01
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Clinical observation of prevention of morphine's adverse effect during epidural analgesia by ondansetron combined with nalo-xone

LAN Zhong-yue, YUE Jun, JIANG Xiao-fen,HU Ming-Lun (Department of Anesthesiology, the First Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000,China)  
Objective: We have observed the clinical effect of ondan-setron combined with naloxone on preventing the adverse effect of epidural morphine analgesia. Methods: Eight gynecological patients scheduled for selective operation were assigned into four groups: group I (the control group, no ondansetron and naloxone), group II (ondansetron group), group III (naloxone group), group IV (ondansetron combined with naloxone group). We used epidural morphine analgesia on all patients after operation. In group II and IV, we used 8 mg ondansetron intravenously after operation, in group III and IV we used 0.4 mg naloxone additionally. Results: All patients of four groups have no significant difference in analgesic effect. Compared with group I, patients of group II ,III and IV had significantly reduced postoperative nausea , vomiting, and itch of skin(P0.05),while among group IV , group II and III there was no significant difference.Compared with the other two groups, patients of group III and IV had lower morbidity of urinal retention (P0.01). Conclusions: Ondansetron combined with naloxone could control the adverse effect effectively, while no effect on analgesic effect.
【CateGory Index】: R614
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