Study of advantage on microwave irradiation technology of synthesizing oxaprozine
DENG Sa , TIAN Yan (Department of Pharmaceutical Chemistry, Dalian Medical University, Dalian 116027,China)
To compare the advantage and shortage of microwave irradiation with common method on synthesizing oxaprozine. Oxaprozine was synthesized by the microwave irradiation in microwave reaction instrument and by the common method in the flask. The yield of the oxaprozine was 83% in17 min by the microwave irradiation while the yield was 65% in 5 h by the common method.[Conclusions] The microwave irradiation expend fewer time and energy and get higher yield than the common method.