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《Journal of Dalian Medical University》 2003-02
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Relationship between infection of HPV-16, HSV-2, EBV, PCNA expression and cervical carcinoma

LIU Jian 1, GUO Yi 2, ZHANG Yan-kai 3, WANG Zhao-hui 4, LIU Min 4,L Peng 4, L Shen 4 (1. Department of Pathology, Dalian University Medical College, Dalian 116622, China; 2. Dalian Hospital of Gynecology and Obstetrics, Dalian 116023, China; 3. Department of Gynecology and Obstetrics, the Second Clinic College, Dalian Medical University, Dalian 116027, China; 4.Center of Laboratory,the Second Clinic College, Dalian Medical University, Dalian 116027, China)  
To observe the relationship between infection of HPV-16, HSV-2 , EBV , PCNA expression and cervical carcinoma . The expression of HPV-16, HSV-2 , EBV and PCNA in 54 cervical carcinoma tissues and 20 cervical normal tissues were examined by immunohistchemistry technique. The expression of HPV-16?HSV-2?EBV in cervical carcinoma tissues and cervical normal tissues were 57.4%, 38.9%and55.6%; 5%, 5% and 10%( P 0.05); the expression of PCNA in cervical carcinomas and normal tissues were 81.5%和15%( P 0.05).With the increase of pathology grading, the positive rate increased. The expression of PCNA in HPV-16 positive group was higher than that in HPV-16 negative group. The difference of PCNA expression between HSV , EBV positive group and HSV , EBV negative group was not significant. The expression of PCNA in the cases of 3 viruses infection were positive. [Conclusion] Infection of HPV-16?HSV-2?EBV promoted the occurrence of the cervical carcinoma.
【CateGory Index】: R737.33
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