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《Journal of Dalian Medical University》 2007-03
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Dynamic experiment study on anti-tumor immunity with SQ (shenqi) compound recipe

LI Qing,FAN Xiao-lei(Department of Medical Microbiology,Dalian Medical University,Dalian 116027,China)  
[Objective] On these bases,this experiment engaged in the dynamic study on anti-tumor immunity with SQ in order to discover the dynamic modulation on the immune system with SQ and the dynamic changes at immune function in mouse with tumor.[Method] All mice were implanted with tumor,3groups were NS control group,3 groups were CY(cyclophsphamide)treatment group.3 groups were SQ treatment group.NS group and SQ group were given NS and SQ decoction respectively by mouth.CY group was injected intraperitoneally with CY.weigh the tumors and fix then.mature NK/Mφactivity and serum IL-12,TNF-α.[Results] SQ could prolong the life span.suppress the growth of mice bearing tumors.Kill tumors rate of SQ treatment group gets 65.68%,that of CY group is 45.76%,difference with that of NS group(P0.05).SQ could enhance the functions of immune system,it could increase NK/Mφactivities in mice bearing tumors.After the first day of stopping drug,SQ treatment group inculde NK/MΦ increase(55.78±2.23)%/(57.23±1.37)% more than NS group(36.51±1.94)%/(38.57±1.15)%,after 5 d/9 d,they maintain(47.43±1.06)/(47.67±1.01)(P0.05).SQ could activate IL-12 and TNF-α.[Conclusion] SQ had significant anti-tumor effect in vivo.
【Fund】: 辽宁省自然科学基金资助课题(00225003)
【CateGory Index】: R285.5
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【Citations】
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