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《Journal of Dalian Medical University》 2007-05
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Effect of chemotatic factor FKN on NF-κB and TNF-α expression in peripheral blood monocytes and intervention of Captopril

SUN Jian,ZHAO Ji-guang,ZHENG Liu-ying,LEI Ming-ming,GUO Hui-jiao,YANG Chun-yan,WU Zhe(The Second Hospital of Jilin University,Changchun 130041,China)  
[Objective] By researching the effects of Fractalkine(FKN)on the expression of NF-κB and TNF-α induced by FKN,We explore one of possible signal transduction pathways of FKN/CX3CR1 in atherosclerosis.And the invention of Captopril.[Methods]①Peripheral blood monocytes were isolated from fresh blood of healthy volunteers by Ficoll-Paque gradient centrifugation.②Divide the extractive peripheral blood monocytes into three groups :control,FKN and captopril groups.③Measure the NF-κB expression of monocytes from each group by immune cytochemsitry.④Collect the supernatant of monocytes from each group,determin the expression of TNF-α by enzyme-linked immunosorbent assay(ELISA).[Results]①The expression of NF-κB(34.80±2.69)% and TNFα(1506.1±69.3)pg/mL from FKN group was increased compared with the expression of NF-κB(3.80±0.95)% and TNFα(80.5±5.5)pg/mL from control group(P0.05).②The expression of NF-κB(27.55±1.96)% and TNF-α(1119.3±116.2)pg/mL from captopril group was decreased compared with the expression of NF-κB(34.80±2.69)% and TNF-α(1506.1±69.3)pg/mL from FKN group(P0.05).[Conclusions]FKN-CX3CR1 increase the expressions of NF-κB and TNF-α in peripheral blood monocytes,which may be one of the mechanisms of contributing to the progression of atherosclerosis;Captopril participates in inhibiting inflammatory and preventing arteriosclerosis perhaps by reducing the expressions of NF-κB and TNF-αin peripheral blood monocytes induced by FKN-CX3CR1.
【CateGory Index】: R543.5
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