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《Journal of Dalian Medical University》 2008-03
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Possibility of VEGF as a marker to evaluate effectiveness of intervention therapy to hepatorcellular carcinoma

SONG Lei1,L Shen (1.Department of Oncology,2.Medical Center,the Second Affiliated Hospital of Dalian Medical University,Dalian 116027,China)  
[Objective] To explore the feasibility of VEGF as a marker to evaluate the effectiveness of transarterial chemoembolization (TACE) of HCC(hepatic cell cancer),and to study the correlation between the level of plasma VEGF level and biological characteristics of HCC.[Methods] Peripheral bloods were sampled at the 1st day before the therapy and at the 1st,3rd,7th,14th,and the 28th day after intervention therapy,respectively,from 13 patients with HCC receiving with TACE treatment.The quantitative sandwich enzyme-linked immunosorbent assay(ELISA) was used to detect the plasma VEGF level.Analysis on the relationship between plasma VEGF levels and hepatic biochemistry level,level of AFP,and index or the imageological features of HCC.[Results] The mean of Plasma VEGF levels at the 1st day before the TACE,at the 1st,3rd, 7th,14th,and the 28th day after the treatment were 284.97±73.60,534.38±130.17,398.13±92.42,363.33±64.42,434.68±77.67 and 374.77±140.46 respectively; VEGF level at the 1st day after the treatment was significantly higher than that before the treatment(P0.05),then it was decreasing gradually as observed on the 3rd and 7th day,and then increased slightly on the 14th day.Higher level of plasma VEGF was observed in patients complicated with tumor embolism in portal vein or with fistula between hepatic artery and portal vein,or patients with remote metastases,but without significant correlation to the site and staining of the tumor,or the presence or not of the coating membrane of the tumor(P0.05),without significant correlation to levels of AFP,GPT,AST,TB,ALB AND PLT(P0.05).Good therapeutic effects were observed in 8 out of 13 patients,with the other 5 patients with poor response,and significant difference existed between the two groups of patients concerning levels of plasma VEGF before treatment and on the 28th day after treatment(P0.05).Significant correlation existed between variation ratio of VEGR before and after treatment(calculated based on the formula of the 28th day/pretreatment×100%) and the deposit of iodized oil in the tumor(r=-0.644,P=0.017).[Conclusion] The level of plasma VEGF can be adopted as an early-stage,sensitive,efficient and AFP-independent marker on evaluation of therapeutic effect of intervention.
【CateGory Index】: R735.7
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