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Effect of compound surfactants on O/W microemulsion region

ZHAO Shan,FAN Qing(Department of Pharmacy,the Second Affiliated Hospital of Dalian Medical University,Dalian 116027,China)  
[Objective] To study the effect of compound surfactants on the O/W microemulsion(ME) region,which was guidance for selection the formulation of ME.[Methods] Phospholipid(PC) and Poloxamers 188(F68) were used as compoundsurfactants,glycerol as cosurfactant,ethyl oleate as oil phase.Prepare the pseud-triangularphase diagrams with different ratio of surfactant/cosurfactant(Km) and F68/PC.Whilefor the PC,glycerol and ethyl oleate system with the same condition.Then,the correspondingarea of O/W ME in both system were compared.The effect of compound surfactantson the O/W ME region was investigated.[Results]The micromulsion region of compound surfactants system was larger than the single surfactant system.In the scope of this study,thearea of ME region was decrease when the Km1 or Km1,while the area of ME was increase with the increase of the ratio of F68.[Conclusions]The microemulsion region of compound surfactants system is more larger than the single surfactant system.The afflication of compound surfactants is a feasible method with guiding significance for the selection of ME formulation.
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