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《Journal of Dalian Medical University》 2008-04
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Value of serum CEA,NSE and CYFRA21-1 in diagnosis,therapeutic efficiency and prognostic estimation in lung carcinoma

XU Fang1,WANG Wei-dong1,HU Hong1,YI ming2(1.Department of Clinical Laboratory,the Second Affiliated Hospital of Dalian Medical University,Dalian 116027,China;2.Clinical Laboratory College of Dalian Medical University,Dalian 116044,China)  
[Objective] To investigate the value of serum CEA,NSE and CYFRA21-1in the diagnosis,pathological classification,stage and therapeutic efficiency in lung carcinoma.[Methods] Using electrochemiluminescence immunoassay,the serum CEA,NSE and CYFRA21-1 levels were measured in 55 cases of lung cancer before and after chemotherapy,as well as in 30 cases of benign pulmonary diseases and 30 cases of healthy controls.[Results] The levels of CEA,NSE and CYFRA21-1 in Patients with lung carcinoma before chemotherapy were significantly higher than those in benign pulmonary diseases and normal controls(P0.01).Different types of lung cancer pathology group of three tumor markers(TM) level of significant difference(P0.01),CEA,NSE,CYFRA21-1 level with clinical staging of increment and increase there were significant differences(P0.01).Combined detection of these tumor markers has an increased sensitivity(P0.05).After chemotherapy,the serum levels of the markers were decreased significantly in the CR and PR patients.but increased or not changed in patients with advanced disease or metastases.[Conclusions] Combined detection of serum CEA,NSE and CYFRA21-1 has a high sensitivity in the diagnosis of lung cancer.The three markers correlate closely with the pathological type and have a value in the treatment of patients who is unable to receive pathological examination.CEA,NSE and CYFRA21-1 can be used as valuable markers for monitoring and evaluation of therapeutic efficacy in lung cancer.
【CateGory Index】: R734.2
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