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《Journal of Dalian Medical University》 2009-04
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Relationship between chemosensitivity and expression of GRP94 in non-small cell lung cancer in vitro

WANG Li-ju1,WANG Zhen-shan2,WANG Qi2(1 Department of Respiratory,Dalian Friendship Hospital,Dalian 116001,China;2.Department of Respiratory,the Second Affiliated Hospital of Dalian Medical University,Dalian 116027,China)  
[Objective] The aim of the research was to study the relationship between chemotherapy resistance and the expression of GRP94 in NSCLC.[Method] Drug sensitivity test was used to detect the resistance to 8 chemotherapy drugs in 52 NSCLC fresh surgical samples by(methylthiazoletrazolium) MTT;the expression of GRP94 was detected by immunohistochemistry.Spearman correlation assay was used to investigate the correlation between GRP94 expression and chemotherapy resistance.[Results] The resistance rates to paclitaxel(PTX),adriamycin(ADM),carboplatin(CBP),topotecan(TPT),navelbine(NVB),vincristine(VCR)、cisplatin(DDP) and etoposide(VP-16) of the 52 samples were: 42.31%,57.69%,63.46%,65.38%,67.31%,73.08 %,78.85% and 90.38%,respectively.The complete resistance to the total 8 chemotherapy drugs was found in 14 cases.There was a significant over-expression of GPR94 in NSCLC tissues.Spearman correlation assay shown that there was correlation between the chemotherapeutics resistance to VP-16 and the expression of GRP94 in NSCLC(P0.05).[Conclusions] The detection of GRP94 may be helpful to the resistance to VP-16 in NSCLC.
【Fund】: 国家自然科学基金(30470464);; 辽宁省科学技术计划项目(No.20022125);; 辽宁省教育厅项目(20223272)
【CateGory Index】: R734.2
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