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《Journal of Dalian Medical University》 2014-03
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Expression and clinical significance of β- tubulinⅢ in advanced gastric cancer tissue

DENG Kun;LIU Qing -yun;LIU Fang;SUN Xiu -hua;ZHANG Yang;Department of Medical Oncology,Lv Shun Kou Qu People's Hospital;Department of Medical Oncology,the Second Affiliated Hospital of Dalian Medical University;  
Objective To explore the correlation between the expression of β-tubulinⅢ in gastric cancer tissues and clinical features of tumor,and to explore the effects of β- tubulinⅢon the disease free survival( DFS) and overall survival(OS) of the patients treated with taxanes as adjuvant chemotherapy. Methods We have collected 34 patients who accepted radical resection of gastric cancer and taxanes as postoperative adjuvant chemotherapy. And all the 34 patients have died.The expression of β- tubulinⅢ was detected by immunohistochemical method. The correlation between the expression ofβ- tubulin Ⅲ in gastric tissues and clinical features of tumor was analyzed by χ2test. The correlation between the expression of β- tubulin Ⅲ on the survival of patients with taxanes as adjuvant chemot herapy was analyzed by Kaplan- Meier approach. Results In 34 cases of gastric cancer patients,15 cases have β- tubulin Ⅲ expression,the positive expression rate is 44. 1% 。The expression of β- tubulin Ⅲ has no correlation with tumor site,size of tumor,depth of invasion,histological type,lymphatic metastasis and TNM stage. The disease free survival(DFS) of patients with positive expression of β- tubulin Ⅲ was 10 months,and 18 months of overall survival(OS). The disease free survival(DFS) of patients with negative expression of β- tubulin Ⅲ was 15 months,and 21 months of overall survival(OS). Compared positive expression of β- tubulin Ⅲ patients,the negatives have significant difference in DFS and median OS,P 0. 05. Conclusion The expression of β- tubulinⅢ in gastric tissues can be used as predictive indicators taxane drug sensitivity,which after gastric cancer radical surgery,but does not correlate to the characteristics of clinical oncology.
【Fund】: 大连市科委课题项目(2010ESF002)
【CateGory Index】: R735.2
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【Citations】
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1 WU Yu-ting,YU Bing-xiang.Respiratory Department for the Old Patients,General Hospital of Guangzhou Command of PLA,Guangzhou 510010,China;Common law study of ERCC1,RRM1 and the class Ⅲ beta-tubulin expression among 105 non-small cell lung cancer patients[J];Chinese Journal of Clinicians(Electronic Edition);2013-01
【Co-citations】
Chinese Journal Full-text Database 2 Hits
1 Li Yi;Lu Dezhao;Jin Lili;College of Life Science Zhejiang Chinese Medical University;;Proteomic Research on the Effect of Resveratrol on Human Cervical Carcinoma HeLa Cells[J];Journal of Zhejiang Chinese Medical University;2013-09
2 Bo WANG;Bin WANG;Lianbin ZHANG;Xiangyang CHU;Gang YU;Department of thoracic surgery,the General Hospital of People's LiberationArmy;SurExam Bio-Tech Co.Ltd.;;Correlation between Expression of TUBB3/STMN1 and EGFR Signaling Pathway in Non-small Cell Lung Cancer[J];Chinese Journal of Lung Cancer;2013-10
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Chinese Journal Full-text Database 1 Hits
1 LIAO Riqiang, LIN Jiayin, QIAO Guibin, LUO Xinlan, YANG Jingji, HUANG Yujuan, WU Yilong. Cancer Center, Lung Neoplasm Department, Guangdong Provincial People’s Hospital, Guangzhou, Guangdong 510080, P.R.China;RRM1 expression in tissue microarray and prognosis analysis in non-small cell lung cancer[J];Chinese Journal of Lung Cancer;2006-05
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