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《Journal of Southeast Univwrsity(Natural Science Edition)》 2001-02
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Cluster Analysis of Codon Usage in Mammalian MHC Class Ⅰ and Ⅱ Genes

Zhou Tong Ma Jianmin Gu Wanjun Sun Xiao Lu Zuhong (Chien Shiung Wu Laboratory, Southeast University, Nanjing 210096)  
Synonymous codon use frequencies of 60 MHC(MHC Ⅰ and MHC Ⅱ) gene sequences from three mammal species are analyzed using hierarchial cluster method. The result shows that codon use frequencies of genes with similar functions are also similar. And for genes with similar functions, difference in codon use frequence caused by species difference is small. In other word, gene function is the main factor that may determine synonymous codon use frequency, and it determines the main classes of codon usage model. Species is a minor factor and it will cause further difference in codon usage in a given class. Research on synonymous codon usage can be helpful in genetic engineering to increase the output of target proteins. It is also a useful tool for gene classification and gene function prediction.
【Fund】: 国家重大基础研究项目!(G19980 5 12 0 0 );; 国家自然科学基金资助项目!( 695 2 5 10 2 ) .
【CateGory Index】: Q52
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