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Study on binding characteristics of (S)-naproxen imprinted polymer and performance of its complexes during preparation

Li Ping Rong Fei Xie Yibing Zhu Xinle Yuan Chunwei ( 1Department of Biomedical Science and Medical Engineering, Southeast University, Nanjing 210096, China) ( 2Department of Bioengineering, Beijing University of Aeronautics and Astronautics, Beijng 100083, China)  
A molecularly imprinted polymer (MIP) was synthesized as the highly chiral selective materials for (S)-naproxen with acrylamide as functional monomers. UV (ultra-violet) studies showed that the template (S)-naproxen and functional monomer acrylamide formed complexes before polymerization and Hyperchem was used to simulate the structures of complexes. The binding capacity of MIP to (S)-naproxen is higher than that of its enantiomer and the chiral separation factor α is 1 87. Scatchard analysis suggests the MIP recognizing (S)-naproxen with two classes of binding sites. The calculated dissociation constant K d,1 and apparent maximum number Q max,1 of binding sites with high affinity are 28 0 μmol/L and 52 94 μmol/g respectively, while K d,2 and Q max,2 of binding sites with low affinity are 0 489 mmol/L and 0 122 mmol/g.
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