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《Journal of Southeast University (Natural Science Edition)》 2005-05
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Binding characteristics of molecularly imprinted polymer for pazufloxacin

Rong Fei~1 Li Ping~2 Yuan Chunwei~1(~1Department of Biological Science and Medical Engineering,Southeast University,Nanjing 210096,China)(~2Department of Bioengineering,Beijing University of Aeronautics and Astronautics,Beijing 100083,China)  
A molecularly imprinted polymer(MIP) with high selectivity was prepared using methacrylic acid(MAA) as monomer,ethylene glycol dimethacrylate(EDMA) as cross-linker and L-pazufloxacin as template.The binding capacity of MIP to the template is higher than that of blank polymer.Scatchard analysis show that the MIP recognized template with two classes of binding sites.The multiple-sites binding model was used to calculate the dissociation constant K_d and apparent maximum number Q_(max) of binding sites.K_(d,1) and Q_(max,1) of the binding sites with high affinity are 23.08μmol/L and 3.65μmol/g,while K_(d,2) and Q_(max,2) of the binding sites with low affinity are 0.43mmol/L and 27.28μmol/g respectively.The selective binding experiment for substrates shows that the affinity and selectivity for pazufloxacin are higher than that for L-norfloxacin and ofloxacin.
【Fund】: 高等学校博士学科点专项基金资助项目(20010286006);; 江苏省自然科学基金资助项目(BK2001015)
【CateGory Index】: TQ460.1;
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