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《Military Medical Journal of Southeast China》 2008-05
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Anti-fatigue experiments of rats using introduced Ciwujia in Nanjing

LIU Fang,HE Wen-bin,WU Hao-xin,DI Liu-qing,HUANG Ying,LU Jing-wen(Nanjing University of Traditional Chinese Medicine based School of Medicine,Nanjing 210029,Jiangsu,China)  
Objective To compare the anti-fatigue effects on rats between introduced Ciwujia in Nanjing and the Northeast local produced Ciwujia by observation of the dynamic changes in serum MDA,SOD,LD and LDH in rate fatigue model.Methods Method The rat exhaustive swimming movement was used to observe the weight and content change of MDA,SOD,LD,LDH in rats after exhaustive exercise.Results The serum levels of MDA were reduced significantly(P0.05) and SOD activity increased significantly(P0.05) in Ciwujia products from Nanjing and Northeast local(middle-dose group,high-dose group) compared with the model group.The levels of MDA/SOD and LD was significantly reduced(P0.05) and LDH increased significantly(P0.05) in Ciwujia of Nanjing and the Northeast local produced(small-dose group,middle-dose group and high-dose group) compared with the model group.Conclusion Ciwujia may play a role in anti-fatigue by reducing the MDA and LD content,enhancing SOD,LDH activity to reduce the free radicals produced in body and enhance the body's ability to eliminate free radicals,reducing the accumulation of metabolites products and improving the ability of body movement.Ciwujias introduced in Nanjing area and produced in the Northeast local area have similar anti-fatigue effect.
【CateGory Index】: R285.5
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