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《Military Medical Journal of Southeast China》 2010-01
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Treatment for femoral head necrosis by combining arterial thrombolysis with marrow mesenchymal stem cells

SHI Yue1,WANG An-ming1,CHEN Qi-zhong2,ZHU Li-li1,LIU Jun-quan3,DING Kai4,GAO Cong-jing1. 1.Department of Radiology;2.Department of Emergency;3.Department of Medical Laboratory;4.Department of Hematology,97 Hospital of PLA,Xuzhou,Jiangsu 221004,China  
Objective To explore the effect of arterial interventional thrombolysis combining with injection of autologous bone marrow mesenchymal stem cells(MSC) on the treatment for avascular necrosis of the femoral head(ANFH).Methods By using the seldinger technique,the catheter was introduced to the supplying artery of the femoral head through the femoral artery on 30 patients of ANFH.Urokinase 4×105 U and papaverine 30mg were injected into the supplying artery,and 1×107~1×108 MSC were injected into the femoral circumflex artery.34 patients of ANFH who received arterial interventional thrombolysis only were used as controls.Results The stenosis and obstruct vessel of the femoral head and neck area in 29 studied patients were revascularized,in which the area of vessel staining of the femoral head increased obviously and necrosis area of the femoral head gradually decreased.The range of motion of the joint was significantly different before and after treatment(P0.01).The efficiency and cure rate of the study group were higher than that of controlled group.Conclusion It is feasible to treat ANFH by arterial interventional thrombolysis combining with injection of autologous bone marrow mesenchymal stem cells.
【CateGory Index】: R681.8
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【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 JIA Yong,CHU Tong-wei,ZHOU Yue(1.Department of Orthopaedics,Wulumuqi General Hospital of Lanzhou Military Area,Wulunmuqi 830000,China;2.Department of Orthopaedics,Xinqiao Hospital,Third Military Medical University,Chongqing 400037,China);Repair process in experimentally induced avascular necrosis of femoral head in rabbits[J];Chongqing Medicine;2006-02
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8 Cells For Avascular Necrosis Of The Femoral Head CHEN Qi-zhong1,SHI Yue2,WANG An-ming2,ZHU Li-li2,LIU Jun-quan3,DING Kai4,GE JI,GAO Cong-jing2.(1.Department of Emergency.2.Department of Radiology.3.Department of Medical Laboratory.4.Department of Hematology.The 97th Hospital of PLA,Xuzhou Jiangsu 221004,China);Clinical Study Of Arterial Interventional Thrombolysis Combined With Regional Injection Of Autologous Bone Marrow Mesenchymal Stem[J];Contemporary Medicine;2010-05
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