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《Military Medical Journal of Southeast China》 2013-03
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Experimental study of methylene blue intraarticular injection on knee joint of rabbit

ZHENG Jia-peng,DING Zhen-qi,MENG Jia-rong,LIU Liang-tian.Department of Orthopaedic,175 Hospital of PLA,Zhangzhou,Fujian 363000,China  
Objective To study the safety of the methylene blue(MB) that intraarticular injected on knee joint of rabbit limb.Methods 48 rabbits were randomly divided into experimental group and control group.Experimental group were received 0.5 mg / kg,1 mg / kg,2 mg / kg MB by intraarticular injection on knee joint and control group received the same amount of physiologic saline.Blood test was examined before and after injection.Pathological examination of articular tissue was taken after sacrificed(12 weeks after injection).Results Compared to control group,blood tests showed no changes in experimental group,and there were no significant difference of articular tissue when the dosage of MB was ≤1 mg / kg.Conclusion The dosage of MB ≤1 mg / kg intraarticular injection on knee joint of rabbit is no significant toxicity and safe.
【CateGory Index】: R684.3
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 CHEN Si-qin reviewer WANG Ying-wei reviser(Department of Anesthesiology, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200092, China);Advance in clinical application of methylene blue[J];Journal of Shanghai Jiaotong University(Medical Science);2008-02
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 ZHENG Yue-huan,CAO Peng,ZHANG Xing-kai,LIANG Yu,WU Wen-jian,GONG Yao-cheng,ZHENG Tao.Department of Orthopaedics,Ruijin Hospital,School of Medicine,Shanghai Jiaotong University;Shanghai Insititute of Traumatology and Orthopaedics,Shanghai 200025,China;Correlation between the lumbar end-plate Modic degeneration and inflammatory factors in Iumbar nucleus pulposus or low back pain[J];International Journal of Orthopaedics;2011-04
2 Zou Huan,Su Jun,Liao Yibin,et al.(Anorectal surgery department, Zhuzhou 331 hospital of Changsha Medical University, , Hunan Province, China, 412002);Combination of methylene blue injection and surgery in the treatment of pruritusani[J];Journal of Colorectal & Anal Surgery;2012-06
3 JIANG Yan1,WEI An-ning1,XU Chuan-shan1,2 (1.Department of Anesthesiologics,Second Affiliated Hospital,Chongqing Medical University,Chongqing 400010,China;2.Center of Rehabilitation Medicine,Second Affiliated Hospital,Chongqing Medical University,Chongqing,400010,China);Evaluation of analgesic effect of photosensitizer methylene blue using electricity pain threshold assay[J];Laser Journal;2009-01
4 SHEN Jin-wen,QU Hang-bo,TONG Pei-jian,SUN-Yi (Dept of Orthopaedic and Traumatic Surgery,Zhejiang Province TCM Hospital,Hangzhou,Zhejiang 310006,China);Clinical application of the treatment with intra-lumbar-discal methylene blue injection after percutaneous laser disc decompression[J];Journal of Clinical Orthopaedics;2008-04
5 LIU Chun-yu,PENG Bao-gan,GAO Chun-hua,JIN Li.Department of Spinal Surgery,General Hospital of Armed Police Force,Beijing 10039,China;Epidural injection of methylene blue on rat lumbar spinal cord and spinal ganglia functional electrophysiological effects[J];Journal of Spinal Surgery;2012-05
6 Liu Guicai,Xue Zhenxun. Department of Oral Maxillofacial Surgery,Stomatological College,Fourth Military Medical University,Xi'an710032 〔;Effects of methylene blue on rat infraorbital nerve[J];Journal of Practical Stomatology;2001-05
7 Jiang Zheng, Yin Zong-sheng Second Ward of Department of Orthopedics, First Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China;Pathophysicological mechanism of discogenic low back pain and tissue engineering technique[J];Journal of Clinical Rehabilitative Tissue Engineering Research;2010-20
8 Wang Gang1,Liu Shang-li2,Chen Zhi-wei1,Guan Hong-gang1,Han Dun-fu2,Shi Yan-zhang31Department of Orthopedic Surgery,Foshan Hospital of Traditional Chinese Medicine,Foshan 528000,Guangdong Province,China;2Department of Orthopedic Surgery,the Second Affiliated Hospital of Sun Yat-sen University,Guangzhou 510120,Guangdong Province,China;3Department of Orthopedic Surgery,the Central Hospital of Shantou City,Shantou 515031,Guangdong Province,China;Can the degeneration adjacent to herniated disc in patients with lumbar disc herniation cause low pack pain?[J];Journal of Clinical Rehabilitative Tissue Engineering Research;2011-22
9 LI Chunlin,LI Fang,ZHANG Zhicheng Department of Orthopedics,General Hospital of Beijing Military Area,Beijing,100700,China;Morphology of endplate in lumbar degenerative disc disease,a MRI study[J];Chinese Journal of Spine and Spinal Cord;2012-05
10 GUO Ji-Dong,HOU Shu-Xun,WU Ye,PENG Bao-Gan,LI Li,SHI Ya-Min(Department of Orthopedics,First Affiliated Hospital of General Hospital of PLA,Beijing 100037,China);PRILIMINARY EFFECTIVENESS EVALUATION OF DISCOGRAPHY AND METHYLENE BLUE INJECTION IN DISCS FOR THE TREATMENT OF DISCOGENIC LOW BACK PAIN[J];Chinese Journal of Pain Medicine;2010-02
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 WuHaishan*,QianQirong,GuQisheng.*DepartmentofOrthopaedicSurgery,ChangzhengHospital,Shanghai200003;IntraarticularSodiumHyaluronateInjectionforthePreventionofOsteoarthritis:AnExperimentalStudy[J];CHINESE JOURNAL OF ORTHOPAEDICS;1996-01
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