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《Military Medical Journal of Southeast China》 2013-03
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Experimental study of methylene blue intraarticular injection on knee joint of rabbit

ZHENG Jia-peng,DING Zhen-qi,MENG Jia-rong,LIU Liang-tian.Department of Orthopaedic,175 Hospital of PLA,Zhangzhou,Fujian 363000,China  
Objective To study the safety of the methylene blue(MB) that intraarticular injected on knee joint of rabbit limb.Methods 48 rabbits were randomly divided into experimental group and control group.Experimental group were received 0.5 mg / kg,1 mg / kg,2 mg / kg MB by intraarticular injection on knee joint and control group received the same amount of physiologic saline.Blood test was examined before and after injection.Pathological examination of articular tissue was taken after sacrificed(12 weeks after injection).Results Compared to control group,blood tests showed no changes in experimental group,and there were no significant difference of articular tissue when the dosage of MB was ≤1 mg / kg.Conclusion The dosage of MB ≤1 mg / kg intraarticular injection on knee joint of rabbit is no significant toxicity and safe.
【CateGory Index】: R684.3
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