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Evaluation of histamine-releasing activity in the serum of the patients with chronic idiopathic urticaria

SUN Ren-shan, LIU Rong-qing, YIE Qing-yi, DIAO Qing-chun, XIANG Ming-ming, ZHANG Li, HUANG Xiu-ying (Department of dermatology, Southwest Hospital, Third Military Medical University, Chongqing 400038,China)  
Objective To evaluate the histamine-releasing activity in the serum of the patients with chronic idiopathic urticaria (CIU). Methods Skin tests with autologous serum and basophil histamine-release assay (BHRA)were performed. Results The positive rates of skin tests with autologous serum and BHRA were 37.5% and 43.75 respectively. Conclusion Certain patients with ClU exhibited elevated histamine-releasing activity in their serum. This implies unusual activating mechanism of their mast cells and basophils. It may be related to autoimmunity.
【Fund】: 重庆市科学技术委员会院士基金
【CateGory Index】: R758.24
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【Secondary References】
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