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Experimental and clinical study of isoniazid in prevention of benign stricture of esophagus

LI Zhi ping, FAN Shi zhi, JIAN Yao guang, WANG Ru wen, HE Yong (Department of Throcic Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042,China)  
Objective To study the effects of isoniazid on the prevention of benign stricture of the esophagus. Methods The study was divided into 2 parts: In the first of animal experimentation, 20 dogs were divided into group A (normal; n =6), group B (positive control, n =6) and group C (isoniazid treated, n =8). The dogs of group B and C were inflicted with alkali burns of the esophagus and those of group C were treated with isoniazid. 8 weeks later, all the dogs were killed to measure the diameter of the stricture and the compliance and collagen content of the esophagus. In the second part, 26 patients with benign stricture of the esophagus were treated with isoniazid after esophageal dilatation. Results In the dogs inflicted with esophageal burns, isoniazid showed an obvious effect of inhibition on the formation of collagen in the esophagus. The diameter of esophageal stricture was significantly larger and the esophageal complicance markedly better in group C than in group B ( P 0.01). In the clinical study, satisfactory result was obtained in 24 cases and the other 2 dropped out of our follow up. Conclusion Isoniazid can prevent benign stricture of the esophagus and is worthy to be further tried clinically.
【CateGory Index】: R96
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