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《Acta Academiae Medicine Militaris Tertiae》 2001-04
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Dynamic changes of pro-and anti-inflammatory cytokines in acute pancreatitis

XIA Shi-hai, ZHAO Xiao-yan, GUO Ping (Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China)  
Objective To explore the significance of the dynamic changes of pro-and anti-inflammatory cytokines in the onset and development of acute panreatitis (AP). Methods Pro-inflammatory cytokines TNFα, IL-1β, IL-6, and IL-8 and anti-inflammatory cytokines IL-10 and IL-1ra in the plasma of 48 patients with AP and 20 healthy individuals were determined with ELISA. Results The levels of all pro-and anti-inflammatory cytokines in plasma was significantly higher in AP patients than in control group (P0.05) in early stage of the disease, and then all levels were decreased gradually, consistent with the alterations of clinical symptoms of the AP patients. Conclusion The dynamic changes of pro-and anti-inflammatory cytokines might play important role in the onset and development of AP.
【Key Words】: acute pancreatitis cytokines tumor necrosis factor IL-1β IL-6 IL-8 IL-10 IL-1 receptor antagonist
【CateGory Index】: R446.6
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