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《Acta Academiae Medicine Militaris Tertiae》 2001-11
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Inhibitory effects of polysaccharides of Angelica sinensis (Oliv.)Diels on murine transplanted tumors

SHANG Peng,YANG Tie hong, JIA Min, MEI Qi bing, ZHU De sheng, ZHAO Wen ming,ZHAO De hua (Institute of Bioengineering, Xi'an Jiaotong University, Xi'an 710049, China)  
Objective: To observe the inhibitory effects of total polysaccharides of Angelica sinensis (Oliv.)Diels on 3 types of murine transplanted tumors. Methods After being injected into armpit with 0.2 ml of 5×10 6 S180 cells, 50 cleaning grade Kunming species mice were divided into 5 groups, 10 of each , randomly. From the following day, the 3 experimental groups were given AP 0 by ip once a day for 10 d with a dose of 30, 100 and 300 mg·kg -1 respectively. Positive control group was given Cy with a dose of 30 mg·kg -1 . On the 11th day, after being weighted up, mice were killed to weight up the masses of tumor, spleen and thymus. After being ip 0.1 ml of 2.5×10 6. Ehrlich ascitic cancer(EAC) cells, 50 cleaning grade Kunming species mice were divided into 5 groups, 10 of each , randomly. From the following day, the 3 experimental groups were given AP 0 by ip once a day for 10 d with a dose of 30, 100 and 300 mg·kg -1 , respectively. Positive control group was given 5 FU with a dose of 20 mg·kg -1 . The average living days within 60 d were observed and the rate of life prolongation was calculated. After being ip 0.1 ml of 1×10 5 L1210 cells, 50 cleaning grade mice were divided into 5 groups, 10 of each, randomly. From the following day, 3 experimental groups were given AP 0 by ip once a day for 10 days with a dose of 30, 100 and 300 mg·kg -1 , respectively. Positive control group was given Cy with dose of 30 mg·kg -1 ,. The average living days within 30 d of each group were observed and then the rate of life prolongation was calculated. Results The results of S180 were: the body masses of 100 mg·kg -1 , 300 mg·kg -1 group were heavier than that of NS group( P 0.05); the body masses of 100 mg·kg -1 , 300 mg·kg -1 group were heavier than that of Cy group ( P 0.05). The tumor masses of NS group and all experimental groups were heavier than that of Cy group( P 0.01). The thymus masses of 100 mg·kg -1 group were lighter than that of NS group( P 0.05), and that of 30 mg·kg -1 and 300 mg·kg -1 group were lighter than that of NS group( P 0.01). The thymus masses of 30 mg·kg -1 group were heavier than that of Cy group( P 0.05), and of 30 mg·kg -1 and 300 mg·kg -1 group were heavier than that of Cy group( P 0.01). There were significance between the masses of spleen of all experimental groups and Cy group( P 0.01). The results of EAC were: The body masses on the 10th day of all experimental groups and 5 FU group were significantly lighter than that of NS group, suggesting that the amount of ascitic liquids produced within 10 days showed significance between these groups and NS group. The rate of life prolongation of 30 mg·kg -1 , 100 mg·kg -1 and 300 mg·kg -1 group was 87.9%, 30.5% and 155.3%( P 0.05), respectively. The results of L1210 were: The rate of life prolongation of 30 mg·kg -1 and 100 mg·kg -1 group was 66.7%( P 0.05) and 56.7%, respectively. Conclusion AP 0 has no obvious inhibitory effect on S180 , but it has influence on immunological organs; AP 0 can reduce the production of ascitic liquids and prolong the rate of life prolongation of mice bearing EAC. AP 0 can also prolong the rate of life prolongation of mice bearing L1210.
【Fund】: 香港HongKongResearchGrantCouncil(HKU72 57 98M)
【CateGory Index】: R73-3
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