Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Acta Academiae Medicine Militaris Tertiae》 2002-08
Add to Favorite Get Latest Update

Expression of glucocorticoid receptor in the liver of severe scalded rats during the early stage of stress

WANG Jun ping, SU Yong ping, LIU Xian hua, ZHAO Jing hong, LIU Du hu, ZHOU Yan hong, QIN Rong (Institute of Combined Injuries, Third Military Medical University, Chongqing 400038, China)  
Objective To investigate the change and significance of glucocorticoid receptor (GR) in the liver of severe scalded rats during the early stage of stress. Methods Western blot was used to detect the expressions of GR in the liver of severe scalded rats and the cultured hepatocytes after challenged with the serum from scalded rats, TNF α, IL 1 or high concentration of dexamethasone respectively. The concentrations of corticosterone, TNF α and IL 1β in the serum of scalded rats were detected with RIA and ELISA. Results The expression of GR in the liver was markedly declined, while the contents of corticosterone, TNF α and IL 1β in the serum were significantly elevated during the early stage of severe scalding. In vitro , the serum of scalded rats, as well as TNF α and IL 1, suppressed the expression of GR in the cultured hepatocytes, while there was no significant effect of high concentration of dexamethasone on the expression of GR. Conclusion The expression of GR in the liver of rats is significantly down regulated during the early stage of severe scalding, and one of the main reasons for this might result from the elevation of inflammatory cytokines after scalding.
【Fund】: 国家重点基础研究发展规划资助项目 (“973”项目 ) (G19990 54 2 0 0 )
【CateGory Index】: R644
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 3 Hits
1 DU Zhi-yong,TAO Jun,YANG Tian-de,et al.(1.Department of Anesthesiology,Xinqiao Hospital,Third Military Medical University,Chongqing 400037,China;2.State Key Laboratory of Trauma,Burns and Combined Injury,Institute of Combined Injury,College of Preventive Medicine,Third Military Medical University,Chongqing 400038,China);Role and mechanism of cervical sympathetic block(SB) in protecting mice from severe burn injury[J];Chongqing Medicine;2007-04
2 DU Zhi-yong, SU Yong-ping, XU Jian-ming, LIAO Lan, RAN Xin-ze, LI Jun, WANG Feng-chao, TANG Tang (State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury, College of Preventive Medicine, Third Military Medical University, Chongqing 400038, China);Effect of burn injury on glucocorticoid receptor in SRC-3 knock out mice[J];Acta Academiae Medicinae Militaris Tertiae;2006-17
3 ZHOU Tao, FAN Xun-mei, WANG Yong-qing, QI Yu-jie, CHEN Hui, QIAN Su-yun. Department of Pediatric Intensive Care Unit, Beijing Children′s Hospital, Capital University of Medical Sciences, Beijing 100045, China;Effects of different doses of hydorcortisone on acute lung injury in rats with early septic shock induced by Escherichia coli[J];Chinese Journal of Pediatrics;2004-09
【Citations】
Chinese Journal Full-text Database 3 Hits
1 LIU Du hu, SU Yong ping, LOU Shu fen, ZHANG Wei, GAO Jing sheng, CHENG Tian min (Department of Radiation Medicine, Institute of Combined Injury of PLA, Third Military Medical University, Chongqing 400038, China);Changes of glucocorticoid receptor in hepatic cytoplasm in scalded rats and its regulation by α-MSH and KPV peptide[J];Acta Academiae Medicine Militaris Tertiae;2001-05
2 XU RENBAO AND TAN JINXIN(Department of pathophysiology,Second Military Medical College,Shanghai);CHANGES IN GLUCOCORTICOID RECEPTOR OF LIVER CYTOSOL AFTER PATHOLOGICAL STRESS IN RATS[J];Acta Physiological Sinica;1982-04
3 Shi Hanping,Li Jianzhen,Qin Luping,et al;Change of glucocorticoid receptor in hepatic and cerebral tissues and its role in hemorrhagic rats/[J];CHINESE CRITICAL CARE MEDICINE;1996-10
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 XD EENBAU TAN JINXING JIANG DAOLONG (Department of Pathophysiology, The Second Military Medical College, CPLA, Shanghai);THE ASSAY OF GLUCOCORTICOID RECEPTOR OF HEPATIC NUCLEI IN RATS[J];Acta Zoologica Sinica;1986-03
2 XU RENBAO TAN JINXING(Department of Pathophynology, The Second Military Medical College, CPLA, Shanghai);CIRCADIAN RHYTHM OF GLUCOCORTICOID RECEPTOR IN RATS[J];Acta Zoologica Sinica;1986-04
3 SHEN Hai ying, ZHOU Yuan guo, LU Jing li, et al. (Research Institute of Field Surgery,Daping Hospital, the Third Military Medical University, Chongqing 400042, China);The study of glucocorticoid efficiency difference between BALB/c and C57BL/6 mice[J];Chongqing Medical Journal;2003-06
4 QU Qiang,SHI Zhong△ (Department of Emergency,Xinqiao Hospital,Third Military Medical University,Chongqing 400037,China);Changes of TNF-α,IL-1β and cortisol in serum and hepatic GR following severe traumatic brain injury[J];Chongqing Medicine;2007-18
5 LIU Xiao hong,LI Su rong,SU Yong ping,et al. (Institute of Combined Injury,Third Military Medical University,Chongqing 400038,China);Expression of glucocorticoid receptor,NF-kB and cytokines of macrophages in mice after burn[J];Journal of Traumatic Surgery;2003-02
6 Xu Renbau, et al (Department of Pathophysioogy);THE EFFECTS OF CHRONIC ADMINISTRATION OF HYDROCORT- ISONE ON THE GLUCOCORTICOID RECEPTOR OF HEPATIC CYTSOL IN RATS[J];Academic Journal of Second Military Medical University;1985-02
7 Yang Yili, et al (Department of Pathophysiology);DETERMINATION OF THE MOLECULAR WEIGHT OF PHOTOAFFINiTY LABELED GLUCOCORTICOSD RECEPTOR IN SCALDED RAT LIVER CYTOSOL[J];Academic Journal of Second Military Medical University;1987-04
8 Fan Jie, Xu Renbao (Department of Pathophysiologv .Shanghai,200433);The Development and Study of the Glucocorticoid Receptor Blockade Animal Model[J];Academic Journal of Second Military Medical University;1993-01
9 Wang Jun;Zhu Jialin; Zhang Baoren; Hao Jiahua; Xu Zhiyun; Tan Jingxing (Department of Thoracicocardiac Surgery, Changhai Hospital, Second Military Medical University, Shanghai, 200433);Regulation of glucocorticoids on glucocorticoid receptor of brain, lung and liver tissues in rabbits[J];ACADEMIC JOURNAL OF SECOND MILITARY MEDICAL UNIVERSITY;1995-01
10 LIU Du hu, SU Yong ping, ZHANG Wei, LOU Shu fen(Department of Radiation Medicine, Institute of Combined Injury of PLA, Third Military Medical University, Chongqing 400038, China);Changes of plasma IL-1β levels in scalded rats and its regulations[J];Acta Academiae Medicine Militaris Tertiae;2001-11
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 ZHONG He-jiang 1,YANG Tian-de 1,SU Yong-ping 2(1.Department of Anesthesiology,Xinqiao Hospital,the Third Military University,Chongqing 400037,China;2.State key laboratory of trauma,Burn and combined Injury Institute of Combined Injury of PLA,the Third Military Medical University,Chongqing 4000038,China);Effects of JAB1 and LPS on glucocorticoid receptor transcription activation[J];Chongqing Medical Journal;2004-11
2 DU Zhi-yong,TAO Jun,YANG Tian-de,et al.(1.Department of Anesthesiology,Xinqiao Hospital,Third Military Medical University,Chongqing 400037,China;2.State Key Laboratory of Trauma,Burns and Combined Injury,Institute of Combined Injury,College of Preventive Medicine,Third Military Medical University,Chongqing 400038,China);Role and mechanism of cervical sympathetic block(SB) in protecting mice from severe burn injury[J];Chongqing Medicine;2007-04
3 LAN Xiu-fu,WANG Ai-ming,SUN Hong-zhen,et al.(Department of Orthopedics,Daping Hospital,Research Institute of Field Surgery,Third Military Medical University,Chongqing 400042,China);Operative risk factors assessment for old orthopaedic patients:a review of 760 cases[J];Chongqing Medicine;2008-05
4 WANG Ai-min,JIANG Yao-guang(Trauma Center,Institute of Surgery Research,Daping Hospital,Third Military Medical University,Chongqing 400042,China);Treatment of severe multiple injuries complicated by bone and joint injury[J];Journal of Traumatic Surgery;2006-04
5 LAN Xiu-fu,WANG Ai-min,SUN Hong-zhen,et al.(Department of Orthopedics,Institute of Surgery Research,Daping Hospital,Third Military Medical University,Chongqing 400042,China);Retrospective analysis of operative risk score for orthopedics surgery in elderly patients with hip fracture in 260 cases[J];Journal of Traumatic Surgery;2008-02
6 DU Cheng Hui 1, FANG Guo En 1* , CHEN Zhan 2, HU Wei 1 (1. Department of General Surgery, Changhai Hospital, Second Military Medical University, Shanghai 200433, China; 2. Department of General Surgery,No.174 Hospital of PLA);Expression of transmembrane tumor necrosis factor receptor in rats with multiple organ dysfunction syndrome[J];Academic Journal of Second Military Medical University;2003-01
7 LIU Du hu, SU Yong ping, LOU Shu fen, ZHANG Wei, GAO Jing sheng, CHENG Tian min (Department of Radiation Medicine, Institute of Combined Injury of PLA, Third Military Medical University, Chongqing 400038, China);Changes of glucocorticoid receptor in hepatic cytoplasm in scalded rats and its regulation by α-MSH and KPV peptide[J];Acta Academiae Medicine Militaris Tertiae;2001-05
8 WANG Qing song, WANG Zheng guo, ZHU Pei fang (Institute of Field Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, China);Establishment of PTSD model in rats and expression of glucocorticoid receptor in the hippocampi[J];Acta Academiae Medicine Militaris Tertiae;2002-02
9 WANG Jun-ping, SU Yong-ping, ZHAO Jin-hong, ZHOU Yan-hong, QIN Rong, LIU Xian-hua (Institute of Combined Injury, Third Military Medical University, Chongqing 400038, China);Effects of TNF-α and IL-1 on expression and function of glucocorticoid receptor in rat hepatocytes in vitro[J];Acta Academiae Medicine Militaris Tertiae;2002-05
10 LI Jun, SHI Zhong, SU Yong ping, LOU Shu fen, LIU Du hu, LIU Xiao hong, WANG Jun ping (Institute of Combined Injury of PLA, Third Military Medical University, Chongqing 400038, China);Changes of serum corticosterone and hepatic glucocorticoid receptor in burned mice[J];Acta Academiae Medicinae Militaris Tertiae;2002-12
【Secondary References】
Chinese Journal Full-text Database 9 Hits
1 ZHANG Min, XIONG Ren-ping, CHEN Xing-yun, LI Ping, ZHAO Yan, LIU Ping, ZHOU Yuan-guo Molecular Biology Center, State Key Laboratory of Trauma, Burns, and Combined Injury, Daping Hospital and Research Institute of Surgery, Third Military Medical University, Chongqing 400042, China;Association of glucocoid receptor binding activity and heat shock protein expressions after acute lung injury in mice[J];Journal of Southern Medical University;2008-05
2 Che Jinwei~* Hu Sen Wu Jing, * Burns Institute,First Hospital Affiliated to the Chinese PLA General Hospital,Beijing 100037,China;Experimental study on continuous monitoring of intestine mucosal blood flow in burn shock dog[J];Infection,Inflammation,Repair;2008-01
3 WU Zhiyuan, ZENG Jiansheng, FAN Xunmei. ICU Department,Beijing Children's Hospital, Capital University of Medical Sciences, Beijing 100045,China;Effects and mechanisms of low-dose hydrocortisone on brain dysfunction in LPS- induced sepsis in rats[J];Chinese Journal of Emergency Medicine;2006-06
4 Wang Quan,Qian Suyun,Yang Xinli(Department of Emergency Center,Beijing Children's Hospital,Capital University of Medical Sciences);Effects of Different Dosages of Hydrocortisone on Homeostasis in Rats at Early Stage of Endotoxic Shock[J];Journal of Capital University of Medical Sciences;2005-05
5 WU Zhi-yuan,ZENG Jian-sheng,FAN Xun-mei(Department of ICU,Beijing Children′s Hospital Affiliated to Capital University of Medical Sciences,Beijing 100045,China);Effect of Low-Dose Hydrocortisone on Expression of Hippocampus Nuclear Factor-Kappa B,Inhibitory Kappa Bin Lipopolysaccharide-Induced Septic Rats[J];Journal of Applied Clinical Pediatrics;2006-06
6 Chai Binying, Qian Feng, Wang Haiying, Wang Wei. Department of Pediatric,Jiangsu Jiangyin People’s Hospital,Jiangsu 214400,China;Clinical Analysis on 33 Neonates with Septic Shock[J];Journal of Medical Research;2009-01
7 WANG Xiao-qiu,ZHOU Yan,ZHOU Xin.Department of Respiratory Medicine,Affiliated First People's Hospital,Shanghai Jiaotong University.Shanghai,200080,China;The roles of glucocorticoid and glucoorticoid receptor in the pulmonary fibrosis caused by acute lung injury induced by lipopolysaccharide in rats[J];Chinese Journal of Respiratory and Critical Care Medicine;2007-05
8 WANG Quan,QIAN Su-yun,YANG Xin-li,JIN Jian-yun,LI Yu-qing.Emergency Center,Beijing Children′s Hospital,Capital University of Medical Sciences,Beijing 100045,China;Effects of different doses of hydrocortisone on the disorder of coagulation in rats at early stage of septic shock[J];Chinese Journal of Pediatrics;2006-01
9 LI Jun,SU Yong-ping,WANG Jun-ping,et al.Institute of Combined Injury of PLA,State Key Lab of Trauma,Burn and Combined Injury,Third Military Medical University,Chongqing 400038,China;Effect of steroid receptor coactivator-3 knock-out on GR during the inflammatory response[J];Chinese Journal of Critical Care Medicine;2008-11
【Secondary Citations】
Chinese Journal Full-text Database 2 Hits
1 Xu Renbao, et alDepartment of Pathophysiology;THE RADIOLIGAND BINDING ASSAY OF GIUCOCORTICOID RECEPTOR IN THE HEPATIC CYTOSOL OF ADRENALECTOMIZED RATS[J];Academic Journal of Second Military Medical University;1981-03
2 Shi Han-Ping,Xu Ren-Bao,Gao Han, Hua Ji-De,Shen Yan-Ming Dept.of General Surgery, Nan Fang Hospital, Guangzhou( 510515);A preliminary study on the mechanism of glucocorticoid depressing IL-1 activity[J];CHINESE JOURNAL OF PATHOPHYSIOLOGY;1995-05
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved