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《Acta Academiae Medicine Militaris Tertiae》 2002-09
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Effects of cholesterol and simvastatin on testosterone and estradiol in atherosclerotic rabbits induced by high cholesterol dietary

QIN Jun, HE Zuo yun (Department of Cardiology, Xinqiao Hospital, Third Military medical University, Chongqing 400037,China)  
Objective To investigate the effects of cholesterol and simvastatin on serum testosterone (TESTO) and estradiol (E 2) in atherosclerosis rabbits induced by high cholesterol dietary. Methods A total of 42 rabbits were equally randomized into 3 groups, normal control, atherosclerosis group induced by high cholesterol food, and simvastatin group fed by cholesterol-enriched diet with simvastatin (Zocor) addition. The levels of serum total cholesterol (TC), triglycerides (TG) and TESTO and E 2 were estimated at the baseline, the end of 8 and 12 weeks after treatment. The extent of aortic atherosclerosis was measured with planimetry for the sudanophilic area. Results At the end of 8 and 12 weeks treatment, serum levels of TC, TG and aortic atherosclerosis areas in rabbits with high cholesterol food were increased compared with normal control group, while the levels of TC, TG and aortic atherosclerosis areas in simvastatin groups were less than that in atherosclerosis group ( P 0.01). Both simvastatin group and atherosclerosis group have no change in testosterone and estradiol during the experiment. Conclusion Neither simvastatin nor cholesterol-enriched diet has no effect on serum testosterone and estradiol in atherosclerotic rabbits induced by high cholesterol dietary.
【CateGory Index】: R965
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【References】
Chinese Journal Full-text Database 5 Hits
1 TAN Hua-bing,HE Qin.People's Hospital of Yunyang Medical College,Hubei 442000,China;The research of prevention effect of fiveleaf gynostemma herb on the rabbits suffered from atherosclerosis and TESTO caused by high cholesterol feedstuff[J];Shanxi Medical Journal;2007-06
2 Qin Jun, He Zuoyun, Li Aimin, et al/Department of Cardiology, Xingqiao Hospital,The Third Military Medical University of the Chinese PLA,Chongqing 400037;The Effect of Serum From Simvastatin Tablet Treated Rabbits on Vascular Smooth Muscle Cell Proliferation[J];Chinese Journal of Microcirculation;2004-02
3 HE Qin, TAN Hua-bing. Department of Endocrinology, Municipal People′s Hospital of Yunyang Medical College, Hubei, 442000, China;Effects of Fiveleaf Gynostemma Herb on microstructure of testicle in adult male rabbits with hyperlipidemia[J];Chinese Remedies & Clinics;2008-01
4 TAN Hua-bing,HE Qin(People's Hospital of Yunyang Medical College,Shiyan 442000,China);Influence of the High lipemia and Fiveleaf Gynostemma Herb on the Microstructure of Testicle of the Adult Male Rabbit[J];Chinese Journal of Comparative Medicine;2008-07
5 Tan Huabing, He Qin Affiliated People’s Hospital, Yunyang Medical College, Hubei (Shiyan 430071);The Effect of Fiveleaf Gynostemma Herb on the Level of Testosterone in Male Rabbits[J];Chinese Journal of Integrative Medicine on Cardio-/Cerebrovascular Disease;2006-12
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 JIN Hong, LI Yu-guang, WANG Dong-ming, TAN Xue-ruiDepartment of Cardiology, the First Affiliated Hospital to Medical College of Shantou University, Shantou, Guangdong 515041, China;Testosterone's Effect on tPA and PAI-1 mRNA Levels of HUVEC[J];Nationlal Journal of Andrology;2005-08
2 ZHU Zhao-ping,HUANG Yu-feng,PAN Lian-jun,XU Hua,XIA Xin-yiLaboratory of Reproduction & Genetics,Nanjing General Hospital of Nanjing Command,PLA,Nanjing,Jiangsu 210002,China;The Effects of Dietbetic Hyperlipidemia on the Develpment of Testes and Penises in Male New Zealand Rabbits[J];Nationlal Journal of Andrology;2005-12
3 HE Qin,TAN Hua-bing.The Renmin Hospital of Yunyang Medical College,Hubei 442000,China;The study of relations of atherosclerosis degree and fatty liver[J];Shanxi Medical Journal;2008-02
4 Gao Qian-ping1, Fu Lu1, Jin Hong2, Li Yuan-shi1, Li Jia1, Huang Ming-xue1, Meng Fan-chao1 1Cardiovascular Department, First Hospital Affiliated to Harbin Medical University, Harbin 150001, Heilongjiang Province, China; 2Department of Cardiology, First Hospital Affiliated to Medical College of Shantou University, Shantou 515041, Guangdong Province, China;Effect of testosterone on endothelial function in atherosclerosis[J];Chinese Journal of Clinical Rehabilitation;2006-25
5 MA Ping-bo~1,ZHU Quan-hong~2,HUANG Zhong-wei~1(1.Department of Pharmacy,Nanfang hospital,Southern Medical University,Guangzhou 510515,China;2.Department of TCM,Southern Medical University,Guangzhou 510515);Effects of Gynostemma pentaphyllum on the blood—lipid and hemorheology in hyperlipidemia rabbits[J];The Chinese Journal of Modern Applied Pharmacy;2005-06
6 LI Qi-yong,JIANG Rong-jian,LI Shuang,et al.(Department of Cardiology,Sichuan Provincial People's Hospital,Chengdu 610072,China);Effects of estrogen replacement therapy on endothelia function in postmenopausal women[J];Practical Journal of Clinical Medicine;2007-05
7 CHEN Xin,WANG Lin,YANG Hang-dong, et al . (Department of Cardiology ,Dongfeng Hospital,Yunyang Medical College,Shiyan,Hubei 442000);The Comparison of the effects of Defibrase,Valsartan and Simvastatin on Atherosclerosis in Rabbits Fed with Cholesterol-Rich Diet[J];Journal of Yunyang Medical College;2004-03
8 TAN Huabing, TAN Zhongke, ZHAO Shiyin Fanxian People's Hospital in Hubei Province, Fanxian(442100) China;Clinical Research on Jiaogulan Multiple Recipe Born Widely in Treating High Blood Lipid Syndrome[J];Zhejiang Journal of Integrated Traditional Chinese and Western Medicine;2004-07
9 TAN Hua-bing, KUANG Ying-wen. People’s Hospital of Yunyang Medical College, Shiyan, Hubei, 442000 ,China;Research of Interference Effect of Fiveleaf Gynostemma Herb on Haemorheology and abnormal CRP of the Rabbits Feeding Diets Rich in Hypercholesterolemia[J];Journal of Chinese Microcirculation;2007-02
10 Tan Huabing, He Qin Affiliated People’s Hospital, Yunyang Medical College, Hubei (Shiyan 430071);The Effect of Fiveleaf Gynostemma Herb on the Level of Testosterone in Male Rabbits[J];Chinese Journal of Integrative Medicine on Cardio-/Cerebrovascular Disease;2006-12
【Secondary References】
Chinese Journal Full-text Database 4 Hits
1 HE Qin,TAN Hua-bing.The Renmin Hospital of Yunyang Medical College,Hubei 442000,China;The study of relations of atherosclerosis degree and fatty liver[J];Shanxi Medical Journal;2008-02
2 HE Qin, TAN Hua-bing. Department of Endocrinology, Municipal People′s Hospital of Yunyang Medical College, Hubei, 442000, China;Effects of Fiveleaf Gynostemma Herb on microstructure of testicle in adult male rabbits with hyperlipidemia[J];Chinese Remedies & Clinics;2008-01
3 TAN Hua-bing,HE Qin(Affiliated People's hospital of Yunyang Medical College,Shiyan 442000);Relationship of the Value of CT Liver and Atherosclerosis[J];Chinese Journal of Comparative Medicine;2008-03
4 TAN Hua-bing,HE Qin(People's Hospital of Yunyang Medical College,Shiyan 442000,China);Influence of the High lipemia and Fiveleaf Gynostemma Herb on the Microstructure of Testicle of the Adult Male Rabbit[J];Chinese Journal of Comparative Medicine;2008-07
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