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《Acta Academiae Medicinae Militaris Tertiae》 2003-02
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Effects of NMDA receptor on glucocorticoid receptor mRNA levels in hippocampus of rats after scald burn stress

LU Jian hua, DANG Jian, LI Hai di, GAO Jing sheng, XIONG Jia xiang (Department of Physiology, Third Military Medical University, Chongqing 400038, China)  
Objective To investigate the changes of glucocorticoid receptor (GR) gene expression in the hippocampus of rats following scald burn stress and the role of N methyl D aspartate (NMDA) receptor in this change. Methods Adult male Wistar rats inflicted with 30% TBSA full thickness scalding were applied as severe scalding stress model. GR mRNA levels in the hippocampus were detected with RT PCR. Results A significant decrease of GR mRNA levels was observed in the hippocampus 2 h after the scalding stress. The decrease could be inhibited when MK 801, an NMDA receptor antagonist, was administered prior to stress, and be augmented with the administration of NMDA, an NMDA receptor agonist, but not be affected by normal saline. Conclusion NMDA receptors are involved in the scalding stress induced down regulation of GR gene expression in the rat hippocampus.
【Fund】: 国家重点基础研究发展规划资助项目 (“973”项目 ) (G19990 54 2 0 1)
【CateGory Index】: R644
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