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《Acta Academiae Medicinae Militaris Tertiae》 2003-12
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Sulfur mustard-induced changes of IL-2 and IL-6 concentrations and lymphocyte DNA damage in dog peripheral blood

LIN Hai, CHEN Zhi long, DONG Zhao jun, WANG Shi li (Department of Military Toxicology, Third Military Medical University, Chongqing 400038, China)  
Objective To study the changes of IL 2 and IL 6 levels and lymphocyte DNA damage in peripheral blood of dog intoxicated by sulfur mustard. Methods Chongqing dogs were subcutaneously injected with sulfur mustard at the dose of 16 mg/kg. Lymphocytes and serum were isolated from dog peripheral blood at different time points as designed. The IL 2 and IL 6 levels in blood serum were measured by radioimmunoassay and lymphocyte DNA damage represented as comet tail length was determined by single cell gel electrophoresis (SCGE). Results Four hours after administration of sulfur mustard, the serum IL 2 and IL 6 levels dogs injected with sulfur mustard decreased and reached the lowest level at 72 h. A significant recovery was found at the time point of 120 h. SCG revealed sulfur mustard induced DNA fragmentation (comet) in dog peripheral lymphocytes. The rate of the damaged lymphocytes and the degree of DNA fragment migration began to increase at 4 h and progressively increased from 24 h to 72 h after sulfur mustard treatment. Conclusion Sulfur mustard intoxication induces early and long lasting decreases in serum IL 2 and IL 6 levels and lymphocyte DNA fragmentation in dog peripheral blood.
【Fund】: 全军“十五”重点课题资助项目 ( 0 1L0 54 )
【CateGory Index】: R827.1
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【Citations】
Chinese Journal Full-text Database 2 Hits
1 YU Wei, SUN Jin su, YAN Chang hui, ZHANG Hui li (Beijing Medical College of PLA, Beijing 100071, China);THE DNA DAMAGE OF HUMAN PERIPHERAL BLOOD LYMPHOCYTES EXPOSURE TO SULFUR MUSTARD IN VITRO[J];Carcinogenesis,Teratogenesis and Mutagenesis;2001-01
2 YANG Qing wu, DONG Zhao jun, WEI Xiang de, ZHANG Hui li (Department of Toxicology, Third Military Medical University, Chongqing 400038, China);Study on the effects of sulfur mustard intoxication on lymphocytes in rats[J];Acta Academiae Medicine Militaris Tertiae;2001-01
【Co-citations】
Chinese Journal Full-text Database 9 Hits
1 SAI Yan, LIU Yong, ZHU Ming xue, ZHANG Li Ming, DONG Zhao jun (Department of Toxicology, Third Military Medical University, Chongqing 400038, China);Cytotoxic action of sulfur mustard on cultured lymphocytes and their caspase-3 expression[J];Acta Academiae Medicinae Militaris Tertiae;2003-13
2 SAI Yan, LIU Yong, ZHU Ming xue, ZHANG Li ming, DONG Zhao jun (Department of Military Toxicology, Third Medical University, Chongqing 400038, China);Interventional effect of tetrapeptide on sulfur mustard-induced lymphocyte apoptosis[J];Acta Academiae Medicinae Militaris Tertiae;2003-14
3 LI Qi hui 1, ZHU Ming xue 2, ZHANG Li ming 2, DONG Zhao jun 1 ( 1Department of Military Toxicology, College of Preventive Medicine, Third Military Medical University, Chongqing 400038; 2Department of Navy Medicine, Second Military Medical University, Shanghai 200433, China);tk gene mutation of L5178Y cells induced by sulfur mustard[J];Acta Academiae Medicinae Militaris Tertiae;2004-16
4 LI Qi-hui 1, ZHU Ming-xue 2, ZHANG Li-ming 2, DONG Zhao-jun 1 ( 1Department of Military Toxicology, College of Preventive Medicine, Third Military Medical University, Chongqing 400038; 2Department of Chemical Defense, College of Navy Medicine, Second Military Medical University, Shanghai 200433, China);Chromosomal aberration and micronucleus formation induced by sulfur mustard[J];Acta Academiae Medicinae Militaris Tertiae;2004-19
5 QIU Limei LI Wenjian FENG Yan ZHOU Libin ZHANG Gaohua (Institute of Modern Physics, the Chinese Academy of Science, Lanzhou 730000) GAO Qingxiang PANG Xinyue (School of Life Sciences, Lanzhou University, Lanzhou 730000);Preliminary study on the time course of heavy ion-induced DNA damage in hepatoma cells[J];Journal of Radiation Research and Radiation Processing;2003-04
6 ZHAO Weiping1,2,3 ZHANG Hong1,3 WANG Yanling1,2,3 LI Ning1,2,3 LIU Bin1 WU Zhenhua1,3 XIE Yi1,3 HAO Jifang1,3 LIU Yang1,2,3 1(Institute of Modern Physics,Chinese Academy of Sciences,Lanzhou 730000,China) 2(Graduate School of Chinese Academy of Sciences,Beijing 100049,China) 3(Key laboratory of Heavy Ion Radiation Medicine of Gansu Province,Lanzhou 730000,China);Effect of low dose ~(12)C~(6+) irradiation on cell cycle and DNA damage in mouse thymus and spleen cells[J];Journal of Radiation Research and Radiation Processing;2008-06
7 JIANG Lin 1,MU Wan-jun 1,LIU Guo-ping 1,XU Yun-shu 1,LUO Shun-zhong 1,GAO Qing-xiang 2 1.Institute of Nuclear Physics and Chemistry,Mianyang 621900,China; 2.School of Live Sciences,Lanzhou University,Lanzhou 730000,China;Application of Single Cell Gel Electrophoresis in Post-Evaluation of Organism Radiation Damage[J];Journal of Nuclear and Radiochemistry;2009-01
8 JIANG Lin,YANG Yu-qing,LIU Guo-ping,et al.1 Institute of Nuclear Physics and Chemistry,Mianyang 621900 China.;Effects of DNA Damage in Peripheral Blood Lymphocytes of human Induced by γ-Rays Irradiation.[J];Chinese Journal of Radiological Health;2006-04
9 QIU Limei,LI Wenjian,FENG Yan,et al.Institute of Modern Physics,Chinese Academy of Sciences,Lanzhou 730000,China\;;Observation of DNA damage of human hepatoma cells irradiated with heavy ions using comet assay[J];Chinese Journal of Radiation Mediation and Protection;2003-03
China Proceedings of conference Full-text Database 1 Hits
1 ;饮用水源遗传毒性可利用技术研究概述[A];[C];2008
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 HU Xiu-li1,LI Cai2,MIAO Chun-sheng2,SUN Bo2,SHI Jing-yu3(1.Department of Analytical Biochemistry,Institute of Frontier Medical Sciences,Jilin University,Changchun 130021,China;2.Department of Pathology,Institute of Frontier Medical Sciences,Jilin University,Changchun 130021,China;3.Harbin Chunyuan Biotechnology Development Co.Ltd.,Harbin 150036,China);Effects of MT egg-milk powder on lipid metabolism and serum zinc and copper levels in diabetic rats[J];Journal of Jilin University(Medicine Edition);2007-05
2 DU Yuanyuan,QIU Keqiang (Institute of Chemistry and Chemical Engineering,Central South University,Changsha 410083);Preparation Process and Applications of Nanometer Zinc Oxide[J];Materials Review;2007-S1
3 SHAO Wei-xing,PENG Da-xin,LU Jian-hong,LIU Xiu-fan~* (Animal Infectious Disease Laboratory, School of Veterinary Medicine, Yangzhou University, Yangzhou,Jiangsu,225009,China);Biological Characteristics of Seven Chicken Cytokines[J];Progress In Veterinary Medicine;2004-04
4 WANG Quan-xi,LI Guo-ping,JIANG Hai-jun(College of Animal Science,Fujian Agrculture and Forestroy University,Fuzhou,Fujian,350002,China);Advance in the Relation Between Zinc and the Apoptosis of Animal Immune Cells[J];Progress in Veterinary Medicine;2007-03
5 LI Lili~1,ZHANG Bin~2,YIN Yulong~1,ZHOU Zhiyang~3,LI Xiaolong~2,LI Tiejun~1(1Institute of Subtropical Agriculture,The Chinese Academy of Sciences,Changsha 410125,China;2College of Animal Science and Technology, Hunan Agriculture University,Changsha 410128,China;3Hunan Gouguang Institute of Medicament Hunan,Changsha 410005,China);Effects of inducement on metallothionein in liver of pig[J];Journal of Guangxi Agricultural and Biological Science;2004-04
6 Liu Shu-gang,Bai He-Ping Kong Xiang-ying.The 260 Hospilal of PLA;Effects of zinc on development of brain and expression of metallothionein in rats[J];;1998-03
7 Li Yanfeng Wang Binhua Huang Wanxia Tu Mingjing(Material Science and Engineering School, Sichuan University, Chengdu 610065) Wang Xiangdong Wang Dan (Environment Science and Engineering School, Sichuan University, Chengdu 610065);Study on the antibacterial properties of nanometer inorganic antibacterial materials[J];New Chemical Materials;2002-06
8 CHEN Yan-zhen,LI Qi-feng,XIAO Cui-hong et al.;EFFECTS OF ZINC OXID ON GROWTH PERFORMANCE,BIOCHEMICAL INDEXES AND DIGESTION OF WEANLING PIGLETS[J];Journal of Heilongjinag August First Land Reclamation University;2001-04
9 LIU Yun-hua~1, ZHANG Bin~1, LI Li-li~2 (1.College of Animal Science and Technology, Hunan Agriculture University,  Changsha Hunan 410128, China; 2.Institute of Subtropical Agriculture, Chinese Academy of Science, Changsha Hunan 410125, China);The Application and Perspective Metallothionein in Farming Industry[J];Ecology of Domestic Animal;2004-04
10 WU Li-zhuan(College of Animal Science,Yangtze University,Jingzhou,Hubei 434025,China)LI Li-li(Institude of Subtropical Agriculture,Chinese Academy of Sciences,Changsha,Hunan 410128,China)ZHANG Bin(College of Animal Science,Hunan Agricultural University,Changsha,Hunan 410128,China);The Application of Metallothionein in Animal Nutrition[J];Journal of Yangtze University(Natural Science Edition);2006-02
【Secondary Citations】
Chinese Journal Full-text Database 5 Hits
1 Meng Ziqiang 1\ and Zhang Lianzhen 2 1\ Division of Environmental Biological Toxicology and Department of Life sciences, Shanxi University, Taiyuan 030006\ 2 China Institute for Radiation Protection, Taiyuan 030006;PRINCIPLE AND METHOD OF THE SINGLE CELL MICROGEL ELECTOPHORESIS (SCGE) TECHNIQUE TO STUDY DNA DAMAGE IN MAMMALIAN CELLS[J];CARCINOGENESIS, TERATOGENESIS AND MUTAGENESIS;1998-06
2 LuoYing, Sun Zhixian. Yang Ruibiao. ZhangZhensheng. (Institute of Radiation Medicine,Beijing 100850).;Quantitative Analysis of DNA StructureChanges in Individual Irradiated Cells.[J];PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS;1994-05
3 Heng Zhengchang\ Zhang Zunzhen (Dept.of Environmental Health,West china University of Medical sciences,Chengdu 610041);Studies of DNA damages induced by 2,4 dichloro 6 aminophenol in V79 cells[J];JOURNAL OF HEALTH TOXICOLOGY;1997-02
4 MENG Zi-qiang~1 ZHANG Lian-zhen~2(1 Division of Environmental Biological Toxicology Department of Life Sciences Shanxi University Taiyuan 030006) (2 China Institute of Radiation Protection Taiyuan 030006);Studies on DNA Damage in Human Blood Lymphocytes Using the Single Cell Microgel Electrophoresis Technique[J];Acta Genetica Sinica;1998-04
5 Yang Qingwu,et al.Department of toxicology.Third military medical university(400038);Study on DNA Damage in Lymphocytes Induced by Mustard Gas Intoxication[J];CHINA PUBLIC HEALTH;1999-04
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