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《Acta Academiae Medicinae Militaris Tertiae》 2003-15
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Effects of cholesterol-inhibitor lovastatin on the activity of MAPK in MCF-7 breast cancer cells

WEI Na, MI Man tian, ZHU Jun dong, LANG Hai bin (Department of Nutrition and Food Hygiene, Third Military University, Chongqing 400038, China)  
Objective To investigate the effects of lovastatin on MAPK activity in MCF 7 breast cancer cells. Methods After MCF 7 cells were treated with 4, 8 and 16 μmol/L lovastatin for 48~72 h, the expressions of ERK1 and p38 MAPK proteins were detected by Western blotting. Their phosphorylation levels were observed by kinase activity assay. Results MCF 7 cells treated with different doses of lovastatin for 48~72 h had no significant effect on the protein level of ERK1, but the activities of ERK1 and the P38 MAPK proteins were down regulated at 72 h after treatment. Conclusion Lovastatin may down regulate the activity of MAPK in MCF 7 cells by means of inhibiting the mevalonate metabolism pathway and/or affecting phosphorylation levels.
【Fund】: 国家自然科学基金资助项目 ( 30 2 7112 8)
【CateGory Index】: R737.9
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