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《Acta Academiae Medicinae Militaris Tertiae》 2003-21
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Immunological mechanism of regulatory T cells acting on effector T cells

ZHENG Jun-song, WU Jun, YI Shao-xuan, HE Wei-feng, CHEN Xi-wei, XIE Zhi-jie, PENG Shuang-fa, DAI Fei (Institute of Burn Research, Southwest Hospital, Third Military Medical University, Chongqing 400038, China)  
Objective To detect the inhibitory co-stimulating cytologic T-lymphocyte-associated antigen 4 (CT-LA4) and cytokines secreted by regulatory T (Treg) cells, and to explore the immunological mechanism of Treg cells acting on effector T cells in co-cultured system(CCS) and separate-cultured system(SCS) . Methods The percentages of CTLA4 and CD28 expressed on the Treg cells and effector T cells were determined. Treg cells were added to mixed lymphocyte reaction (MLR) system in CCS and Trans Well Millicell-PCF SCS. The inhibitory effects of Treg cells on the MLR were detected after adding or not adding anti-IL-10 or TGF-B1 to the reacting systems. Results Compared with effector T cells, Treg cells expressed higher level of CTLA4 and secreted higher levels of IL-10 and TGF-B1 ( P 0.01) . The inhibitory effect of Treg cells co-cultured with effector T cells was much stronger than that in separate cultured group (P 0.01). Moreover, the inhibition rate of Treg cells on effector T cells through the secretion of IL-10 was higher than that through the secretion of TGF-B1 ( P 0.01) . Conclusion Both cell-to-cell contact and cytokine secretion mechanisms are involved in the regulation of T cells by CD4+ CD25+ Treg cells. Cytokines have stronger inhibitory effect on effector T cells by means of secretion of IL-10.
【Fund】: 国家自然科学基金资助项目(30200264);; 国家自然科学基金资助重大项目(39993430-2)~~
【CateGory Index】: R392
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