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《Acta Academiae Medicinae Militaris Tertiae》 2003-21
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Experimental study of the preventive effect of tetramethylpyrazine on simulated high altitude acute lung injury in dogs

FENG Lian-gui, WANG Jian-chun, GUO Xian-jian, QIAN Gui-sheng, MAO Bao-ling, WU Guo-ming (Faculty of Medical Laboratory Sciences,Third Military Medical University,Chongqing 400038,China)  
Objective To explore the roles of tetramethylpyrazine (TMP) in the prevention of simulated high altitude acute lung injury(ALI) in dogs. Methods A total of 21 dogs were randomly divided into ALI, treatment and control groups in a simulated altitude of 4 000 m. All animals were sacrificed at 6 h after exposure to the altitude . Results TMP could inhibit the decrease of the peripheral WBC count and alleviate the infiltration of inflammatory cells in lungs and pulmonary edema. No marked improvement of the decreased level of arterial PaO2 was found. Conclusion TMP can partially improve acute lung injury due to fat embolism.
【CateGory Index】: R594.3
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