Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Acta Academiae Medicinae Militaris Tertiae》 2004-10
Add to Favorite Get Latest Update

Effects of different doses of lipopolysaccharide on acute lung injury in rats

LI Qi, QIAN Gui sheng, ZHANG Qing, WANG Chang zheng (Institute of Respiratory Diseases, Xingqiao Hospital, Third Military Medical University, Chongqing 400037, China)  
Objective To investigate the changes of plasma interleukin 4 (IL 4) in rats with acute lung injury (ALI) induced by lipopolysaccharide (LPS) and to explore the relationship between IL 4 and ALI. Methods A total of 120 Wistar rats were randomly divided into 2, 4, 6, and 8 mg/kg groups according to different doses of LPS administration at each observing time point. A control group (NS), receiving saline injection, was also employed. The indexes of respiratory rate, PaO 2, wet weight/dry weight (W/D) of lung lobes, and pathological changes were observed at 1, 2, 4, and 6 h after injury. The plasma IL 4 content was detected by enzyme linked immunosorbant assay. Results ① Various degrees of ALI in rats were induced by different doses of LPS. Acute respiratory distress syndrome (ARDS) was induced under the condition of LPS ≥6 mg/kg. ② LPS could induce increased plasma IL 4 in rats. The peak value of plasma IL 4 in rats increased significantly under the condition of LPS ≥6 mg/kg. Conclusion ① ALI model can be duplicated by injection of LPS. ② LPS ≥6 mg/kg is the critical dosage for ARDS in rats. ③ The obvious increase of plasma IL 4 may be associated with the occurrence of ALI/ARDS.
【Fund】: 国家自然科学基金资助重点项目 ( 39730 2 10 ) ;; 全军医学科研“十五”计划重点课题 ( 0 1Z0 74 )~~
【CateGory Index】: R563.8
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 10 Hits
1 XU Shi-jun,SHEN Ying-jun,JIN Shen-rui,XIE Yu-huan(Chendu university of TCM chengdu 610075);Efect of Ramulus Cinnamomi Volatile Oils on Expression of Toll-like Receptor2 and Receptor4 and MYD88 on Acute Pneumonia Model Induced by LPS[J];Journal of Chengdu University of Traditional Chinese Medicine;2008-03
2 XIONG Yi,WANG Xing-yong,ZHOU Hai-yin,HE Rong,DING Miao,QIU Chun-lan,ZHOU Jing,HE Yin ( Intensi Care Unit,Children’s Hospital,Chongqing Medical University,Chongqing 400014,China);Protective effects and mechanism of pyrrolidine dithiocarbamates on acute lung injury of LPS-induced septic rats[J];Acta Academiae Medicinae Militaris Tertiae;2009-21
3 XIONG Yi1,WANG Xing-yong2 (1. Woman and Children's Hospital of Zunyi,Guizhou Province,Guizhou Zunyi 563000,China; 2. Children's Hospital of Chongqing Medical University,Chongqing 400014,China);The Change of Serum IL-6,IL-17 on the Acute Lung Injury of Sepsis Rats and Its Significance[J];Journal of Pediatric Pharmacy;2010-01
4 SHEN Ying-jun,XU Shi-jun,XIE Yu-huan,JIN Shen-rui,QIN Xu-hua(Chengdu University of Traditional Chinese Medical,Chengdu 610075,China);Comparison of the effects of VORC and VOHS on NF-κB signal transduction passway in rats acute pheumonia model[J];West China Journal of Pharmaceutical Sciences;2008-02
5 JIANG Jing-jing,SHI Xue-yin,YUAN Hong-bin,ZHU Qiu-feng,WANG Cheng-cai,SUN Hai-jing.Department of Anesthesiology,Changzheng Hospital,Second Military Medical University,Shanghai 200003,China;Effects of ulinastatin on NF-κB expression in lung tissue of rats with acute lung injury[J];Medical Journal of Chinese People's Liberation Army;2009-05
6 LU Guohua DAN Renfei ZHOU Jianying YAO Hangping. Department of Pulmonary Diseases,First Affiliated Hospital,Medical College Of Zhejiang University,Hangzhou 310003,China;Protective effect of Ginaton on lipopolysaccaride-induced acute lung injury in rats[J];Chinese Journal of Emergency Medicine;2006-08
7 YE Zheng-long1,XU Qiao-lian1,LI Shi-rong1,ZOU Hui1,QIU Hai-bo2(1.Department of Intensive Care Unit,Nangjing Jiangbei Hospital,Southeast University,Nanjing 210048,China;2.Department of Intensive Care Unit,Zhongda Hospital,Southeast University,Nanjing 210009,China);Influence of ventilation on inflammatory response in rat with acute lung injury[J];Journal of Southeast University(Medical Science Edition);2009-06
8 WANG Jiangping. The Children's Hospital of Zhejiang University Medical School, Hangzhou 310007, China;Protective effects of vitamin C on acute lung injury induced by lipapalysacchharide in mouse[J];Clinical Education of General Practice;2007-04
9 QIAO Li,ZHANG Jin-song,CHEN Yan,HE Bin,SHAO Bing-xia. Emergency Center,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China;Effect of penehyclidine hydrochloride on the expression of VEGF in rats after early lung injury[J];Practical Geriatrics;2009-01
10 XIONG Yi1,HE Zhi-jiang2,WANG Xing-yong1,ZHOU Hai-yin1,HE Rong1,DING Miao1,QIU Chun-lan1,ZHOU Jing1,HE Yin1(1.Intensive Care Unit,Children′s Hospital of Chongqing Medical University,Chongqing 400014,China;2.Department of Pediatrics,Bao′an Maternity and Child Health Hospital,Shenzhen 518133,Guangdong Province,China);Protective Mechanism of Chloroquine on Lipopolysaccharide-Induced Acute Lung Injury in Rat[J];Journal of Applied Clinical Pediatrics;2009-18
China Proceedings of conference Full-text Database 1 Hits
1 WEI Hong-xia~1 YANG Yi~2 QIU Hai-bo~2 GUO Tao~2 ZHAO Min-min~2 CHEN Qiu-hua~2. 1 Department of Infection,Nanjing Second Hospital,Southeast University,Nanjing 210003,China; 2 Department of Critical Care Medicine,Zhong-Da Hospital and School of Clinical Medicine,Southeast University,Nanjing 210009,China;Effects of the different fluids on alveolar epithelium barrier in rats with acute lung injury[A];[C];2008
【Citations】
Chinese Journal Full-text Database 1 Hits
1 LI Qi,QIAN Gui sheng,ZHANG Qing,GAO Zheng jin, ZHAO Qing,LI Hai bin (Institute of Respiratory Disease, Xingqiao Hospital,Third Military Medical University,Chongqing 400037,China);Study of acute lung injury induced by different doses of lipopolysaccharide in rats[J];Acta Academiae Medicine Militaris Tertiae;2001-11
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 WANG Yu-hong,LIU Gang,YU Ji-yao,et al.(Department of Surgery,PLA Navy General Hospital,Beijing100037,China);Relationship of nuclear factor kappa B and systemic inflammatory response syndrome (SIRS) caused by open abdominal injury and seawater immersion in rats[J];Journal of Traumatic Surgery;2009-02
2 DU Cheng Hui 1, FANG Guo En 1* , CHEN Zhan 2, HU Wei 1 (1. Department of General Surgery, Changhai Hospital, Second Military Medical University, Shanghai 200433, China; 2. Department of General Surgery,No.174 Hospital of PLA);Expression of transmembrane tumor necrosis factor receptor in rats with multiple organ dysfunction syndrome[J];Academic Journal of Second Military Medical University;2003-01
3 GU Wei1,JIAO Jian-ming2,DU Qian-ru2,CHEN Min2(1.Department of Infectious Diseases,College of Clinical Medicine,Dali University,Dali,Yunnan 671000,China; 2.Affiliated Hospital of Dali University,Dali,Yunnan 671000,China);Preparation of SIRS rat model induced by hemorrhage with endotoxin[J];Journal of Dali University;2007-04
4 LI Qi,QIAN Gui sheng,ZHANG Qing,GAO Zheng jin, ZHAO Qing,LI Hai bin (Institute of Respiratory Disease, Xingqiao Hospital,Third Military Medical University,Chongqing 400037,China);Study of acute lung injury induced by different doses of lipopolysaccharide in rats[J];Acta Academiae Medicine Militaris Tertiae;2001-11
5 REN Cheng shan, ZHAO Zhi qiang, LI Xia, LU Hai hua, GUO Zhong jie, GAO Quan jie, QIAN Gui sheng (Institute of Respiratory Diseases, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China);Disturbance of acid-base balance in patients with SIRS/MODS[J];Acta Academiae Medicinae Militaris Tertiae;2004-10
6 XIE Xiang-bin~1,YUAN Shi-ying~(1,),LI Jin~1,et alDepartment of Anesthesiology,Xiehe Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,Chin;Protective effects of hypertonic-hyperoncotic solution on the acute lung injury induced by lipopolysacchharide in rats[J];International Journal of Anesthesiology and Resuscitation;2006-02
7 Huang Lingjin,Liu Chengwu,Cheng Jianxing.(Department of Pathophysiology,Guangxi Medical University,Nanning 530021 China);ESTABLISHMENT OF RAT MODEL WITH MULTIPLE ORGAN DYSFUNCTION SYNDROME INDUCED BY ABDOMINAL CAVITY INFECTION AND ITS PATHOLOGICAL CHANGES[J];Journal of Guangxi Medical University;2010-06
8 QIN Qiyu,LI Yong,CHEN Hu,et al.Department of Liver and Gallbladder Surgery, The First Hospital of Heibei Medical University,Hebei,Shijiazhuang 050031;The effect of TNF-α and IL-6 on rats with acute pancreatitis complicated with SIRS[J];Hebei Medical Journal;2008-02
9 LIU Changfa1), FENG Guoqing2), FU Runfang2), ZHANG Wei1), XU Hongping1), QI Chihong3) 1)Department of Pharmacy, Zhengzhou Railway Professional Technological College, Zhengzhou 450052 2)Department of Pharmacology, College of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001 3) Henan Pharmaceutical School,Kaifeng 475001;Effect of compound dextromethorphan granules on cough-relieving in guinea pigs and on the movement of esophageal cilia in toads[J];Journal of Zhengzhou University(Medical Sciences);2007-03
10 DAI Hong-wei,YU Jun,HAN Ke-jie,et al. Department of Neurosurgery,The Second Affiliated Hospital,Shandong University of Traditional Chinese Medicine,Jinan 250001,China;Establishment of a model of multiple organ dysfunction syndrome resulted by craniocerebral trauma in rats[J];Nervous Diseases and Mental Health;2008-04
China Proceedings of conference Full-text Database 3 Hits
1 Zengping,Wu Weikang,Yang Yiyu,Guangzhou Children's Hospital(510120);The early intervention.of Sinitang decoction in SIRS model rats[A];[C];2008
2 LI Yu-mei,WEI Hong-chang,YU Xiao-wan,LI Jing,HAN Yu;Establishment and evaluation on rat ARDS model with stubborn hypoxemia[A];[C];2009
3 ;Expression Of pulmonary vascular endothelial growth factor in rats model of acute lung injury[A];[C];2004
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 Dou Hongman, Wang Yuanxun, Cai Shengrong,et al Dept of Pathology, the First Affiliated Hospital of Anhui Traditional Chinese Medical College, Hefei 230031;Observation on airway pathological histology and superminusular strueture in the rats with Pulmonary Qi Deficiency Syndrome[J];Anhui Medical Journal;2004-05
2 Li Wengxiong, Qu Lifang, Feng Xuemei, et al Chinese Academy of Sciences,Shanghai Institue of Materia Medica (Shanghai,210075,China);Effect of Chinese Complex Prescriptions to LPO, SOD and Erythrocyte Immunity of Experimental Senile Hyperliopoprotememia[J];JOURNAL OF CHENGDU UNVERSITY OF TARDITIONAL CHINESE MEDICINE;1997-03
3 Kazuyoshi Kuwano ,Division of Respiratory Diseases,Department of Internal Medicine,Jikei University School of Medicine,Tokyo,Japan;;Epithelial Cell Apoptosis and Lung Remodeling[J];中国免疫学杂志(英文版);2007-06
4 GENG Zhao hua,LI Long gui,HUANG Jian (Department of Cardiology,Xinqiao Hospital,The Third Military Medical University,Chongqing 400037,China);Effects of Perindopril on amount and mRNA expression of Ca~(2+) release channels of myocardial sarcoplasmic reticulum in rats with chronic heart failure[J];Chongqing Medical Journal;2001-01
5 ZHANG Fang, QIAN Gui-sheng, QIAN Pin, et al. (Insititute of Respiration Diseases of PLA,Xinqiao Hospital,the Third Military Medical Univisity,Chongqing 400037,China);Investigation of repressing expression and activity of glucocorticoid receptor in rat alveolar macrophage with RNA interference technique[J];Chongqing Medical Journal;2005-05
6 LI Yong-wang,ZHANG De-ming,QIAN Gui-sheng,et al.(1.Department of Anesthesiology;2.Department of Respiration,Xinqiao Hospital,Third Military Medical University,Chongqing 400037,China);Expression and roles of MD2 in activation of alveolar typeⅡ cells induced by lipopolysaccharides[J];Chongqing Medicine;2007-16
7 HUANG Jian,LIU Huai-qiong,YANG Zhi-huan (Trauma Center,Institute of Surgery Research,Daping Hospital,Third Military Medical University,Chongqing 400042,China);Fat embolism syndrome after trauma[J];Journal of Traumatic Surgery;2004-05
8 Tang Weijun,Lu Xinhua,Zhou Daxian,et al. (Dept of Pharmacology of Chenzhou Medical College,Chenzhou, Hunan 423000);Pharmacology Research on Analgesia Effects of Cinnamom Twig[J];Journal of Chenzhou Medical College;2003-01
9 DENG You-hua,GUO Zheng-heng,CHEN Hong-ming,et al.Department of Cardiothoracic Surgery, YouJiang National Medical College,Baise,533000,China;Impacts of Anisodamine(654-2) Combined with Exogenous Pulmonary Surfactant on Tomor Necrosis Factor (TNF-α),Structure Changes of Lung Tissue During Pig's Lung Ischemic-reperfusion Injury[J];Journal of Chinese Physician;2002-04
10 GENG Zhao hua, LI Long gui, HUANG Jian, HU You yong, GENG Jian meng, HE Zuo yun, ZHU Shan jun (Department of Cardiology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China);Effect of peridopril on myocardial sarcoplasmic reticulum Ca~(2+)pump in rats with chronic cardiac insufficiency[J];Acta Academiae Medicine Militaris Tertiae;2000-09
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 XU Shi-jun,SHEN Ying-jun,JIN Shen-rui,XIE Yu-huan(Chengdu university of TCM,sichuan Chengdu 610075,China);Effects of Ramulus Cinnamomi Volatile Oil on PTK Activation in Rat Model of Acute Lung Injury[J];Journal of Chengdu University of Traditional Chinese Medicine;2007-04
2 XU Shi-jun,SHEN Ying-jun,JIN Shen-rui,XIE Yu-huan(Chendu university of TCM chengdu 610075);Efect of Ramulus Cinnamomi Volatile Oils on Expression of Toll-like Receptor2 and Receptor4 and MYD88 on Acute Pneumonia Model Induced by LPS[J];Journal of Chengdu University of Traditional Chinese Medicine;2008-03
3 LUO Zhen-chun1,HUANG Yan2,QIN Kai-xiu1,LING Zong-xiu1(1Department of Emergency,2Department of Anesthesiology,Second Affiliated Hospital,Chongqing Medical University,Chongqing 400010,China);Effect of ginkgolide B on NF-κB expression in pulmonary tissue of mice with acute lung injury[J];Acta Academiae Medicinae Militaris Tertiae;2009-14
4 SONG Mei-fang,JIN Shen-rui,ZENG Nan,et al(Chengdu University of TCM Chengdu 611137);Effect of VOHS and VOCC on Pathway of TLR2/4 in Mouse Peritoneal Macrophage which Stimulated by LPS in Vitro[J];Journal of Chengdu University of Traditional Chinese Medicine;2011-02
5 SHEN Ying-jun,XU Shi-jun,XIE Yu-huan,JIN Shen-rui,QIN Xu-hua(Chengdu University of Traditional Chinese Medical,Chengdu 610075,China);Comparison of the effects of VORC and VOHS on NF-κB signal transduction passway in rats acute pheumonia model[J];West China Journal of Pharmaceutical Sciences;2008-02
6 SHE Jin-ming1,2,ZHONG Ming1,LIANG Yi-zeng1,TU Bing2,LUO Ai-rong2(1.College of Chemistry and Chemical Engineering,Central South University,Changsha,Hunan,410083 P.R.China;2.Department of Pharmacy,Changde Vocational and Technical College,Changde,Hunan,415000 P.R.China);Analysis of essential oil components in Ramulus cinnamomi by GC-MS combined with Heuristic evolving latent projections[J];West China Journal of Pharmaceutical Sciences;2010-04
7 HAN Kai-yu,SHANG Yu,Lü Fu-zhen,et al(Department of Respriratory Diseases,The Second Clinical College,Harbin Medical University,Harbin 150081,China);Effect of tetrandrine on mediators of inflammation in rats with acute lung injury induced by lipopolysaccharide[J];Journal of Harbin Medical University;2009-05
8 ZHANG Xin-hong,DUAN Yun-you,WANG Hai-long,RUI Meng,WANG Yu,WANG Da-peng,HU Ming. Department of Respiratory,Naval General Hospital,Beijing 100037,China;A rabbit model of acute lung injury induced by freshwater drowning[J];Medical Journal of Chinese People's Liberation Army;2009-04
9 ZHANG Hong SUN Geng-yun~*.* Respiratory Department,The First Affiliated Hospital of Anhui Medical University,Hefei 230022,China;Protective effects of angiotensin Ⅱ receptors antagonist on the LPS-induced lung acute injury[J];Chinese Journal of Emergency Medicine;2007-09
10 PENG Xia,MA Jianfei,LI Chengcheng,et alDepartment of Nephrology,The First Affiliated Hospital China Medical University,Shenyang (110001);Effect of Ulinastatin on Lipopolysaccharide-induced Interleukin 15,Interleukin 6 Expression in Rat Peritoneal Mesothelial Cells[J];Chinese Journal of Integrated Traditional and Western Nephrology;2010-10
【Secondary Citations】
Chinese Journal Full-text Database 7 Hits
1 Sheng Zhiyong, Xu Shihao, Shi Zhiguo, Yu Yong, Wang Yaping, Yan Guangtao Zhu xiaofeng, Lu Yi, Sun Shirong, Wang Huaibin, Tian Huimin. Trauma Center, Postgraduate Medical College of PL A, 304th Hospital, PLAWang Yinhuai, Wang Yuzhuo. Institute of Experimental Animals, Academy of Medical. Sciences of China, Beijing;INJURIOUS EFFECTS OF TNF-a ON VISCERAL ORGANS OF GERM-FREE RATS: A PRELIMINARY REPORT[J];Medical Journal of Chinese People's Liberation Army;1992-03
2 Qian Guisheng. Xinqiao Hospital, The Third Military Medical University, Chongqing 400037;SYSTEMIC INFLAMMATORY RESPONSE SYNDROME,ACUTE LUNG INJURY AND ACUTE RESPIRATORY DISTRESS SYNDROME[J];MEDICAL JOURNAL OF CHINESE PEOPLE'S LIBERATION ARMY;1999-05
3 Hu Sen,Sheng Zhiyong,Xue Lipo et al. 304th Hospital of PLA, Beijing l00037;A SERILIZED STUDIES OF ANIMAL MODELS OF POSTTRAUMATIC MULTIPLE ORGAN DYSFUNCTION SYNDROME[J];MEDICAL JOURNAL OF CHINESE PEOPLE'S LIBERATION ARMY;1996-01
4 Hu Sen,Sheng Zhiyong , Lin Hongyuan et al. 304th Hospital of PLA, Beijing 100037;EARLY DIAGNOSIS AND LABORATORY PREDICTON FOR MULTIPLE ORGAN DYSFUNC- TION SNYDROME[J];MEDICAL JOURNAL OF CHINESE PEOPLE'S LIBERATION ARMY;1996-01
5 HU Sen, SHENG Zhi yong, ZHOU Bao tong, et al. 304th Hospital, Beijing 100037.;A Study of Animal Model of the Delayed Two Phase Multiple Organ Dysfunction Syndrome in Goats[J];CHINESE JOURNAL OF TRAUMATOLOGY;1996-02
6 Hu Sen,Sheng Zhiyong,Liang Yanjie,et al.Burn Institute,304th Hospital of PLA,Beijing 100037;Feeding E.coli plus severe hypovolemic shock induces gut origin sepsis and multiple organ dysfunction syndrome in rabbits[J];CHINESE CRITICAL CARE MEDICINE;1998-10
7 Hu Sen,Sheng Zhiyong,Xue Libo,et al.Burn Institute,304th Hospital of PLA,Beijing 100037;A trial to reproduce multiple organ dysfunction syndrome in animals with intraperitoneal injection of cantharidin[J];CHINESE CRITICAL CARE MEDICINE;1998-10
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved