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《Acta Academiae Medicinae Militaris Tertiae》 2004-17
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Roles of hepatocyte cytochrome P450 2E1 in nonalcoholic steatosis of rat liver

HU Lu, CHEN Dong feng, SHI Hong tao (Department of Gastroenterology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China)  
Objective To study the roles of hepatocyte cytochrome P450 2E1 in model of nonalcoholic steatosis in rats Methods A total of 40 Wistar rats were randomly divided into two groups: control group (C) and high fat diet induced fatty liver group (H) The expression of hepatocyte cytochrome P450 2E1 antigen in rat model of nonalcoholic steatosis was detected by immunohistochemical method and Western blotting Malondialdehyde (MDA) contents were also determined Results MDA contents and the expression of hepatocyte cytochrome P450 2E1 antigen in rat model of nonalcoholic steatosis induced by high fat diet were higher than those in the normal controls ( P 0 05, P 0 01), and positively associated with the degrees of severity of nonalcoholic steatosis Conclusion Cytochrome P450 2E1 may be associated with liver damage due to nonalcoholic steatosis and lipid peroxidation
【CateGory Index】: R575.5
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