Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Acta Academiae Medicinae Militaris Tertiae》 2005-15
Add to Favorite Get Latest Update

Antioxidation of mythic fungus broth on senile rat models induced by D-galactose

GUO Fang~1, QI Ya-juan~2, ZHANG Yong-jian~1, WANG Yong-li~1 (~1Department of Pharmacology, Hebei Medical University, Shijiazhuang 050017, ~2Department of Pharmacology, North China Coal Medical College, Tangshan 063000, China)  
Objective To study the effect of mythic fungus broth (FMF) on the free radicals, erythrocyte membrane, sexual function and ultrastructure of the brain mantle in D-galactose induced senile rats. Methods ①Thirty SD rats of 24 months old were divided into 3 groups: water control, FMF group (1.2 g/kg) and vitamin E group (0.8 g/kg). The action of antiaging in rats was studied by determining the oxidative activity of the plasma, the content of vitamin C, glutathin and malondialdehyde in the blood serum and the brain tissue. ②Sixty SD rats of 6-7 months were divided into 6 groups: control group, model group, 0.3 g/kg FMF group, 0.6 g/kg FMF group, 1.2 g/kg FMF group and vitamin E group. All rats except the control group were injected subcutanously with 1% D-galactose at the dose of 50 mg·kg~(-1)·d~(-1). The antiaging action was studied by measuring the activities or content of superoxide dismutase (SOD), malondialdehyde (MDA), glutathione peroxide (GSH-Px), monoamine (MAO) and lipofuscin (LPF) in the blood serum or/and the brain tissue. The protein content in the brain tissue was determined by Coomassive technique. The ultrastructural change in the cerebral neurons was observed by transmission electron microscope.③The effect of FMF on the erythrocyte membrance was studied by assaying the MDA content. ④The change of sexual function was studied by the copulation test in 40 female and 40 male SD rats of 4-5 months. Results ①In the aging rats, the 1.2 g/kg FMF increased the oxidative activities of the plasma (P0.01) and the content of vitamin C of the blood serum(P0.01), decreased the MDA content in the blood serum and the brain tissue (P0.05), but had no significant effect on the GSH. ② 0.3 g/kg FMF enchanced the GSH-Px activities (P0.01),decreased the MDA content in the blood and brain tissue (P0.01) and the LPF content in the brain tissue (P0.05), but had no effects on other enzyme and metabolites; 0.6 g/kg FMF decreased the LPF content (P0.05) and MDA content (P0.01), enchanced the SOD activities (P0.05); 1.2 g/kg FMF increased the SOD activities(P0.05) and GSH-Px content (P0.05), decreased the MDA content (P0.01 or 0.05) and LPF content (P0.05), and the MAO activities (P0.05) in the blood serum and/or the brain tissue. D-galactose increased lipofuscin, made mitochondria swollen and degenerated, mitochondria broken and vacuolated, nucleus teratic, nuclear membrane plicated, nucleolus shifted to edge, and Golgi complex vacuolated. The FMF improved remarkedly the changes induced by D-galactose. ③ 0.6 g/kg FMF and 1.2 g/kg FMF decreased the contents of the MDA in the erythrocyte membrane (P0.01), but 0.3 g/kg did not. ④In the test of strengthening sexual function, 1.2 g/kg FMF shortened the latency of the penis erection (P0.01). In the mating test, 0.6 g/kg FMF increased the number of capture and ejaculation (P0.01), shortened the latency of capture (P0.01) and ejaculation (P0.01), 0.3 g/kg FMF only shortened the latency of capture (P0.05). Conclusion FMF can delay aging, decrease lipid oxidation, increase the activity of antioxidase, enhance the sexual function of male rats.
【CateGory Index】: R285
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 4 Hits
1 Zhuang Zhi-qiang,Chen Jing-zao,Pei Zhao-hui Department of Radiation Medicine,School of Preventive Medicine,Fourth Military Medical University,Xi'an 710032,Shaanxi Province,China;Effect of infrasound on sexual behaviors of male rats[J];Chinese Journal of Clinical Rehabilitation;2006-37
2 Zhang Bin1,Xia Zuo-li1,Zhao Xiao-min1,Zhang He-ping2 1Department of Brain Microcirculation,Taishan Medical College,Taian 271000,Shandong Province,China;2Second People's Hospital of Dong'e County,Liaocheng 252217,Shandong Province,China;Establishment and evaluation of oxidative stress models[J];Chinese Journal of Clinical Rehabilitation;2006-44
3 LIU Yu-mei 1,2 ,OUYANG Wu-qing 1,YANG Guang-min1,ANG Ge1,ZHANG Li 1 (1College of Animal Science and Technology, Northwest Agriculuture and Forestry University YangLing 712100; 2College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471003, China);THE PROTECTIVE EFFECTS OF EXTRACTS OF MAIZE PLUMULE AGAINST OXIDATIVE DAMAGE IN BRAIN TISSUE OF MICE[J];Acta Nutrimenta Sinica;2007-04
4 GAO Wengeng1, WANG Jing2, FAN Mingtao3, YAN Xiaojuan1 (1.Department of Life Sciences, Yuncheng University, Yuncheng 044000, Chian; 2. Tonghua Institute of Manufactured Product Quality Inspection, Tonghua 134001, China; 3. College of Food Science and Engineering, Northwest A & F University, Yangling 712100, China);Determination of Ganoderma Lucidum polysaccharide from solid fungal substance rich in starch[J];China Brewing;2009-10
Chinese Journal Full-text Database 2 Hits
1 XU Gang (School of Food Science and Biotechnology and Environmental Engineering, Zhejiang Gongshang University, Hangzhou 310035,China);Study on Scavenging Free Radicals by Active Compounds from Natural Ganoderma lucidum[J];Journal of Wuxi University of Light Industry;2005-01
2 YOU Yu hong, LIN Zhi bin (Department of Pharmacology, School of Basic Medical Sciences, Health Science Center, Peking University, Beijing 100083, China);Antioxidant effect of Ganoderma polysaccharide peptide[J];Acta Pharmaceutica Sinica;2003-02
Chinese Journal Full-text Database 10 Hits
1 WANG Bang wu 1, YANG Xin lin 1, ZHANG Li gang 2, SUN Zhi jie 2, XU Jian lan 3 (1 Center for Research on Materials Science, Beijing Institute of Technology, Beijing100081, China; 2 School of Chemical Engineering and Materials Science;Studies on Extraction, Separation and About the Antibacterial Activity of Acidic Components from Ganoderma Lucidum[J];Journal of Beijing Institute of Technology;2002-01
2 HUANG Shu-ming~(1,4),YANG Xin-lin~1,HUANG Jian~1,WU Jian-hua~1, XU Jian-lan~3,ZHU He-sun~2 (1.School of Life Science and Technology, Beijing Institute of Technology, Beijing100081, China; 2.School of Material Science and Engineering, Beijing Institute of Technology, Beijing100081, China; 3.Sanlian Hi-Tech Limited Company, Wuxi, Jiangsu214023, China; 4.Bengbu Technological Academy, Bengbu, Anhui233030, China);HPLC Fingerprinting of Triterpenoids from Ganoderma Lucidum[J];Journal of Beijing Institute of Technology;2004-05
3 HUANG Shu-ming~(1,4),YANG Xin-lin~1,HUANG Jian~1,XU Jian-lan~2,ZHU He-sun~3 (1.School of Life Science and Technology, Beijing Institute of Technology, Beijing100081, China; 2.Sanlian Hi-Tech Limited Company, Wuxi, Jiangsu214023, China; 3.School of Material Science and Engineering, Beijing Institute of Technology, Beijing100081, China; 4.Bengbu Technological Academy, Bengbu, Anhui233030, China);Method for the Rapid Quantification of Triterpenoids in Ganoderma Lucidum by Ultraviolet Spectrometry[J];Journal of Beijing Institute of Technology;2004-06
4 LIU Shu fang,DU Bao dong, JI Bai chun (Department of Otorhinolaryngology and Head Neck Surgery, First Hospital, Jilin University ,Changchun 130021,China);Effects of infrasound exposure on action potential in guinea pig[J];Journal of Jilin University of (Medicine Edition);2004-01
5 ZHANG Gui-ru~1, DU Bao-dong~1, WANG Xiao-ming~2,WANG Hai-tao~1,Sun Le~1 (1. Department of Otolaryngology and Head-Neck Surgery, First Hospital, Jilin University, Changchun 130021,China;2. Department of Laboratory, First Hospital,Jilin University, Changchun 130021,China);Influences of intense infrasound on ultrastructures of hair cells of cochlea in guinea pigs[J];Journal of Jilin University of (Medicine Edition);2005-02
6 Guan Hong-chang, Cong Zheng Department of Pharmacology, Beijing Medical College;EFFECTS OF LINGZHI POLYSACCHARIDE D_6 ON THE BIOSYNTHESIS OF NUCLEIC ACIDS AND PROTEIN[J];;1981-04
7 School of Pharmaceutical Sciences He Yunqing, Li Rongzhi, et al;STUDIES OF ACTIVE POLYSACCHARIDES OF GANODERMA LUCIDUM[J];;1989-03
9 LIN Zhi-Bin △ (Department of Pharmacology,Peking University School of Basic Medical Sciences,B eijing 100083,China);Progress of studies on the anti-tumor activity and immunomodulating effect of Ganoderma[J];Journal of Beijing Medical University;2002-05
10 NIU Jun-fang 1,WANG Hong-geng 1,FANG Zheng 1, LI Zheng-ping 1,YAN Guan-qiang 2 (1.College of science Key Laboratory of Bioinorganic Chemistry of Hebei, AgricultureUniversity of Hebei,Baoding 071001,China; 2.College of Humanities,Agriculture Unive;Study on the extraction methods and the distribution of germanium in germanium-enriched Ganoderma lucidum[J];Journal of Agricultural University of Hebei;2002-04
【Secondary References】
Chinese Journal Full-text Database 4 Hits
1 HAN Fei,ZHOU Meng-liang(Academy of State Administration of Grain,Beijing 100037,China);An Experimental HepG2 Cell Model of Hydrogen Peroxide Induced DNA Oxidative Injury[J];Food Science;2011-05
2 YAN Yan,GUO Jie,YANG Fei,XUE Wei(Shangdong Provincial Centre for Disease Control and Prevention,Jinan 250014,China);Anti-Oxidative Effect of Gynostemma and Hawthorn Extracts on the Aging Mouse Model Induced by D-galactose[J];Laboratory Animal Science;2009-03
3 Liang Lan1,2,Sun Lihua2,3,Xu Shuping2,Yang Yanyan2,Zhao Mingyao1,Ahsana Dar4,Iqbal Choudhary4,Dr.Bina4,Dr.Shaheen4,Liu Xinmin2 (1.Pathophysiology Department of Basic Medicine,College of Zhengzhou University,Zhengzhou 450001,China;2.Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100193,China;3.Experimental Research Center,China Academy of Chinese Medical Sciences,Beijing 100700,China;4.International Center for Chemical and Biological Sciences,University of Karachi Karachi,75270,Pakistan);Cytoprotection of 13 Pakistan Medicinal Plants on Neurotoxicity of PC12 Cells[J];World Science and Technology(Modernization of Traditional Chinese Medicine and Materia Medica);2011-04
4 FU Qing-jie,LI Ming-chun,LI Qiang (401th Hospital of PLA,Shandong Qingdao 266071,China);Protective effect of carboxymethyl chitosan(CMC) on the liver and brain in mice damaged by D-galactose[J];Chinese Journal of Hospital Pharmacy;2011-18
【Secondary Citations】
Chinese Journal Full-text Database 6 Hits
1 Xu Gang; Zhang Hong; Hu Jian (Department of Food Science, Hangzhou Institute of Commerce, Hangzhuo 310035);Leaching Method of Flavone from Bamboo Leaves[J];CHINESE JOURNAL OF ANALYTIEAL CHEMISTRY;2000-07
2 胡迎芬 胡博路 孟 洁 杭 瑚 (青岛大学化学系,青岛 266071);月季花抗氧化作用的研究[J];SCIENCE AND TECHNOLOGY OF FOOD INDUSTRY;2000-04
3 LI Dan XIAO Gang DING Xiao- lin (Wuxi University of Light Industry,214036);Study on The Free Radical Scavenging Effects of Tartary Buckwheat Flavone[J];Food Science and Technology;2000-06
4 Fan Xiao, Yan Xiaojun, Fang Gnoming, Chen Yumin and Lou Qingxiang(Institute Of Oceanology, The Chinese Academy Of Sciences, Qingdeo 266071);ANTIOXIDATIVE PROPERTIES OF HIGH MOLECULAR WEIGHT POLYPHENOLS FROM BROWN SEAWEED[J];Acta Hydrobiologica Sinica;1999-05
5 Zhou Xuanwei Lin Juan (Shanxi Key Laboratory of Bio-Resources, Hanzhong Teacher's College, Hanzhong 723000);Resources of Wild Ganoderma spp. in China and their Development and Utilization[J];Acta Edulis Fungi;1999-01
6 Xing Guoqing,Qiu Yufang,Xing Dongsheng (Dept.of Pharmacology,Taishan Medical College 271000;The People's Hospital of Feicheng City 271600);EFFECT OF GANODERMA POLYSACCHARIDE ON SUPEROXIDE DISMUTASE OF OLD-MICE[J];JOURNAL OF TAISHAN MEDICAL COLLEGE;1999-02
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved