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《Acta Academiae Medicinae Militaris Tertiae》 2005-17
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Lethal effects of energy controllable steep pulses on U_(14) cervical cancer in mice

HU Ya~(1), HU Li-na~(2), MI Yan~(3), YAO Cheng-guo~(3), XIONG Lan~(3), SUN Cai-xin~(2) ( ~(1)Department of Obstetrics and Gynecology, No. 324 Hospital of PLA, Chongqing 400020; ~(2)Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Huaxi Medical College, Sichuan University, Chengdu 610041; ~( 3)College of Electrical Engineering, Chongqing University, Chongqing 400044, China)  
Objective To investigate the lethal effects of energy controllable steep pulses on U_(14) cervical cancer in mice. Methods A total of 48 female BALB/C mice were inoculated subcutaneously with the solution of U_(14) cervical cancer cells line at the right hind limb. The histomorphological changes were observed and the suppressive curve of the tumor was analyzed between experimental group (n=26) treated with steep pulse stimulation and control group (n=22) without any treatment. Results Steep pulses electrical field could selectively injure tumor cells and inhibit cell proliferation. In the experimental group, the phenomena of pyknosis, karyorrhexis and karyolysis of tumor cells were observed by light and electron microscope and got worse as time prolonged. Conclusion Energy controllable steep pulses have a lethal or inhibitory effects on cervical cancer cells.
【Fund】: 国家自然科学基金资助项目(50077027)~~
【CateGory Index】: R737.33;
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【Co-citations】
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1 WANG Ping-ling 1, HU Li-na 1, LI Cong 1, SUN Cai-xin 2, MI Yan 2, WANG SHI-bin 2, YAO Cheng-guo 2 ( 1Department of Obstetrics and Gynecology, The Second Affiliated Hospital, Chongqing University of Medical Science, Chongqing 400016; 2Key Lab of High Voltage Engineering and Electrical New Technology, Ministry of Education, Chongqing 400044, China);Experimental study of energy controllable steep pulses and RNA interference targeting H-ras gene on inhibiting growth of xenografted tumor of ovarian cancer cells[J];Acta Academiae Medicinae Militaris Tertiae;2005-06
2 LUO Xiao-dong 1 , HU Li-na 1 , SUN Cai-xin 2 , YAO Chen-guo 2 , XIONG Lan 2 , MI Yan 2 , WANG Shi-bin 2 ( 1 Department of Obstetrics and Gynecology, The Second Affiliated Hospital,Chongqing University of Medical Sciences, Chongqing 400016, 2 Key Lab of High Voltage Engineering and New Electrical Technology, Chongqing University, Chongqing 400044, china);Effects of energy controllable steep pulse on human umbilical vein endothelial cells in vitro[J];Acta Academiae Medicinae Militaris Tertiae;2005-21
3 YU Jin-mei 1,XIONG Zheng-ai 1,LING Xiao-juan 1,SUN Cai-xin 2,YAO Chen-guo 2,HONG Chuan 2,MO Deng-bin2,MI Yan 2,WANG Shi-bin 2(1Department of Obstetrics and Gynecology,The Second Affiliated Hospital,Chongqing University of Medical Sciences,Chongqing 400010;2Key Lab of High Voltage Engineering and Electrical New Technology of Ministry of Education,Chongqing University,Chongqing 400044,China);Metrological study on damaging effect of steep pulsed electric field on fresh excised calf liver[J];Acta Academiae Medicinae Militaris Tertiae;2006-24
4 WU Xiao-juan1, YAO Zhen-wei1,TANG Jun-ying1, YAO Chen-guo2, SUN Cai-xin2 (1Department of Gynecology and Obstetrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016; 2 Key Laboratory of High Voltage and Electrical New Technology of Ministry of Education, College of Electrical Engineering, Chongqing University, Chongqing 400044, China);Growth inhibition and apoptosis induction of nanosecond steep pulse on human ovarian carcinoma cell line SKOV_3[J];Acta Academiae Medicinae Militaris Tertiae;2007-17
5 LI Cong1,HU Li-na 1,2,DONG Xiao-jing1,SUN Cai-xin3,MI Yan 3(1Department of Obstetrics and Gynecology,The Second Affiliated Hospital,Chongqing Medical University,Chongqing 400016;2 Department of Obstetrics and Gynecology,The Second Affiliated Hospital,West China Hospital,Sichuan University,Chengdu 610081;3Key Laboratory of High Voltage and New Electrical Techniques of Ministry of Education,College of Electrical Engineering,Chongqing University,Chongqing 400044,China);Ovarian cancer cell apoptosis by high intensity electric pulses:mitochondrial mechanism[J];Acta Academiae Medicinae Militaris Tertiae;2008-13
6 LUO Xiao-dong 1 , HU Li-na 1 , SUN Cai-xin 2 , YAO Chen-guo 2 , XIONG Lan 2 , MI Yan 2 , WANG Shi-bin 2 (1.Department of Obstetrics and Gynecology, the Second Affilate Hospital, Chongqing University of Medical Science, Chongqing 400010, China; 2. Key Laboratory of High Voltage Engineering and Electrical New Technology Under the State Ministry of Education,Chongqing University, Chongqing 400030, China);Experimental Study of Energy Controllable Steep Pulse in the Treatment of Rat with Subcutaoneous Transplantive Tumor[J];Journal of Chongqing University(Natural Science Edition);2005-07
7 Xiao-Jing Dong,1 Li-Na Hu,1 Yun-Shan Zhu,1 Chuan Hong,2 Cong Li1 and Xiao-Dong Luo11.Department of Obstetrics and Gynecology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, 400010, P.R.China 2.Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, 610041, P.R.China 3.Key Laboratory of Voltage Engineering and Electrical New Technology of Ministry of Education, Chongqing University, Chongqing, 400044, P.R.China;Effects of energy controllable steep pulses on intracellular calcium concentration and cell membrane potential[J];Chinese Journal of Cancer;2009-09
8 ZHU Yunshan1,HU Lina2,DONG Xiaojing3,et al (1.Second Affiliated Hospital Zhejiang University College of Medicine, Hangzhou Zhejiang 310009, China; 2.Second Huaxi University Hospital, Sichuan University, Chengdu Sichuan 610041, China; 3. Second Affiliated Hospital of Chongqing University of Medical Science, Chongqing 400010, China);The Effect of Energy Controllable Steep Pulse on Proliferation and Apoptosis of Rabbit VX_2 Breast Tumor[J];Journal of Practical Obstetrics and Gynecology;2008-04
9 Li Cong1 Hu Li'na1 Wang Pingling1 Dong XiaoJing1 Zhu Yunshan1 Yao Chenguo2 Mi Yan21(Department of Obstetrics and Gynecology,The Second Affiliated Hospital,Chongqing University of Medical Science,Chongqing 400010,China)2(College of Electrical Engineering,Chongqing University,Chongqing 400044,China);Steep Pulse Changes the Expression of Tissue Factor in Ovarian Tumor[J];Journal of Biomedical Engineering;2008-02
10 Zhu Yunshan1 Hu Lina2 Dong Xiaojing3 Luo Xiaodong3 Sun Caixin41(Second Affiliated Hospital,College of Medicine,Zhejiang University,Hangzhou 310009,China)2(Second West China Hospital,Sichuan University,Chengdu 610041,China)3(Second Affiliated Hospital,Chongqing University of Medical Science,Chongqing 400010,China)4(Chongqing University,Chongqing 400044,China);The Proliferating Ability Inhibited by Energy Controllable Steep Pulse in Breast Cancer Cell Line and Its Mechanism[J];Journal of Biomedical Engineering;2009-05
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1 ZHANG Wen-Jian1, WU Lian-Qiu1, YE Li-Ya2, LOU Jin-Ning1,21. Department of Pathophysiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100005, P. R. China2. Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, 100029, P.R.China;Immunologic Characteristics of Tumor-derived Vascular Endothelial Cells[J];Chinese Journal of Cancer;2005-05
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4 LUO Xiao-dong 1 , HU Li-na 1 , SUN Cai-xin 2 , YAO Chen-guo 2 , XIONG Lan 2 , MI Yan 2 , WANG Shi-bin 2 ( 1 Department of Obstetrics and Gynecology, The Second Affiliated Hospital,Chongqing University of Medical Sciences, Chongqing 400016, 2 Key Lab of High Voltage Engineering and New Electrical Technology, Chongqing University, Chongqing 400044, china);Effects of energy controllable steep pulse on human umbilical vein endothelial cells in vitro[J];Acta Academiae Medicinae Militaris Tertiae;2005-21
5 YU Jin-mei 1,XIONG Zheng-ai 1,LING Xiao-juan 1,SUN Cai-xin 2,YAO Chen-guo 2,HONG Chuan 2,MO Deng-bin2,MI Yan 2,WANG Shi-bin 2(1Department of Obstetrics and Gynecology,The Second Affiliated Hospital,Chongqing University of Medical Sciences,Chongqing 400010;2Key Lab of High Voltage Engineering and Electrical New Technology of Ministry of Education,Chongqing University,Chongqing 400044,China);Metrological study on damaging effect of steep pulsed electric field on fresh excised calf liver[J];Acta Academiae Medicinae Militaris Tertiae;2006-24
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9 LUO Xiao-dong 1 , HU Li-na 1 , SUN Cai-xin 2 , YAO Chen-guo 2 , XIONG Lan 2 , MI Yan 2 , WANG Shi-bin 2 (1.Department of Obstetrics and Gynecology, the Second Affilate Hospital, Chongqing University of Medical Science, Chongqing 400010, China; 2. Key Laboratory of High Voltage Engineering and Electrical New Technology Under the State Ministry of Education,Chongqing University, Chongqing 400030, China);Experimental Study of Energy Controllable Steep Pulse in the Treatment of Rat with Subcutaoneous Transplantive Tumor[J];Journal of Chongqing University(Natural Science Edition);2005-07
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