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《Acta Academiae Medicinae Militaris Tertiae》 2006-05
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Tumor specific immune response in postoperative gastric cancer patients induced by dendritic cells vaccine

WANG Hao, YU Pei-wu, ZHAO Yong-liang, SHI Yan, WU Miao, ZENG Dong-zhu, CAI Zhi-ming (Department of General Surgery, Southwest Hospital, Third Military Medical University, Chongqing 400038, China)  
Objective To investigate tumor specific immune response in postoperative patients with gastric cancer induced by dendritic cells vaccine. Methods Dendritic cells were produced and pulsed with self tumor antigens in vitro. Twenty-five patients with gastric cancer were treated with DCs vaccinations. DCs vaccine was administered subcutaneously once a week for 4 times to the postoperative patients after they finished chemotherapy. PBMC mixed lymphocyte reactions (MLR) and delayed-type hypersensitivity (DTH) reactions to self tumor lysates were measured in vitro before and after the vaccinations. Results The level of IFN-γ released by PBMC of patients were (184±20), (467±55), (700±88), (257±38) pg/ml before and 2, 4 and 8 weeks after vaccination respectively and IL-4 level was (66±8), (69±9), (66±7), (61±7) pg/ml. The intensity of MLR and the level of IFN-γ in PBMC supernatant increased significantly after vaccination, while the IL-4 level in PBMC supernatant had no significant changes. Sixteen patients developed delayed type hypersensitivity reactions to tumor lysates after immunization. Conclusion The dendritic cells vaccine can induce antigen specific immunity in postoperative patients with gastric cancer.
【CateGory Index】: R735.2
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