Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Acta Academiae Medicinae Militaris Tertiae》 2006-06
Add to Favorite Get Latest Update

Gene expression profiles of toxicated BALB/c mouse liver exposed to tetracycline

GAO Li-hong~(1),AO Lin~(1),HU Ran~(1),LIU Jin-yi~(1),HUANG Ming-hui~(2),YANG Meng-su~(2),CAO Jia~(1)(~(1)Department of Hygiene Toxicology,College of Preventive Medicine,Third Military Medical University,Chongqing 400038,~(2)Genome Technological Application Institute,City University of Hong Kong)  
Objective To study the molecular mechanism of the toxic effect for tetracycline acting on liver using toxicological microarray.Methods Utilizing the mouse toxicological microarray and animal model of tetracycline injuring BALB/c mouse liver,both of which were established by our department,we observed the gene expression profiles in different dose groups and at different time points after tetracycline treatment,and primarily analysed the function of these differentially expressed genes using Gene Ontology Consortium analysis system and hierarchical method.Results Multiple differentially expressed genes were found,and an obvious difference in the profiles was found in those treated with high-dose and low-dose tetracycline.The differentially expressed genes of all time points in high-dose group were divided to four clusters,which respectively related to the molecular mechanism of repressed enegy metabolism,enhanced protein synthesis and degradation,impared system of resisting oxidation,signal transduction genes changing to accelerate apoptosis,repressed genes associated of drug metabolism.Conclusion The analysis using toxicological microarray can offer us many clues on molecular level for studying the mechanism of the toxic effect of tetracycline acting on liver.
【Fund】: 国家杰出人才基金资助项目(3012503);; 国家自然科学基金资助项目(30200354 30271136)~~
【CateGory Index】: R363
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 2 Hits
1 GAO Li-hong,AO Lin,HU Ran,LIU Jin-yi,CAO Jia,HUANG ming-hui,YANG Meng-su(Department of Hygiene Toxicology,Third Military Medical University,Chongqing 400038,China);CLUSTERING ANALYSIS OF GENE EXPRESSION PROFILES IN MOUSE HEPATOTOXICITY INDUCED BY FOUR DRUGS[J];Journal of Preventive Medicine of Chinese People's Liberation Army;2008-01
2 ZHANG Hao1, LUO Yi1, ZHOU Qi-xing1,2 (1.Key Laboratory of Pollution Process and Environmental Criteria at Ministry of Education, College of Environmental Science and Engineering, Nankai University,Tianjin 300071,China; 2.Key Laboratory of Terrestrial Ecological Process, Institute of Applied Ecology,Chinese Academy of Sciences, Shenyang 110016, China);Research Advancement of Eco-toxicity of Tetracycline Antibiotics[J];Journal of Agro-Environment Science;2008-02
【Citations】
Chinese Journal Full-text Database 1 Hits
1 AO Lin, CAO Jia~*, HUANG Ming-hui, WU Ya-zhou, LIU Jin- yi, ZHANG Yan-qi, ZENG Zhi-xiong, YANG Meng-su.*Department of Hygien Toxico logy, Preventive Medical College, Third Military Medical University, Chongq ing 400038,China Corresponding author: CAO Jia;Gene expression profiles in early stage of B ALB/c 3T3 cells’transformation promoted with 12-O-tetradecanoylphorbol-13-a cetate[J];Chinese Journal of Preventive Medicine;2005-02
【Co-citations】
Chinese Journal Full-text Database 3 Hits
1 WANG Yan 1 , GUO Qiao-nan 2 , ZHANG Bo 1 , LIU Xin 1 , BAI Yun 1 ( 1 Department of Molecular Genetics, College of Medicine, 2 Department of Pathology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China);Ability of malignant transformation of rat IEC-6 by MNNG and PMA[J];Acta Academiae Medicinae Militaris Tertiae;2006-04
2 ZHANG Hao1, LUO Yi1, ZHOU Qi-xing1,2 (1.Key Laboratory of Pollution Process and Environmental Criteria at Ministry of Education, College of Environmental Science and Engineering, Nankai University,Tianjin 300071,China; 2.Key Laboratory of Terrestrial Ecological Process, Institute of Applied Ecology,Chinese Academy of Sciences, Shenyang 110016, China);Research Advancement of Eco-toxicity of Tetracycline Antibiotics[J];Journal of Agro-Environment Science;2008-02
3 Yin huiqing He Fucheng Zhang Lan et al The Department of clinical laboratory of Zhengzhou University(Zhengzhou 450052);Effects of 12-tetradecanoyl-phorbol-13-acetate on Expression of NDRG_1 mRNA and Proliferation of Human Esophageal Carcinoma EC9706 Cells[J];Shaanxi Medical Journal;2008-07
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 AO Lin 1 ,ZENG Zhi-xiong 2 ,FANG Zhi-jun 2 ,HU Ran 1 , GAO Li-hong 1 ,YANG Meng-shu 2 ,CAO Jia 1, (1.Department of Toxicology,College of Preventive Medicine,Third Military Medical University,Chongqing400038,China; 2.Applied Research Center for Genomic Technology,City University of Hong Kong,Hong Kong,China);The Design and Fabrication of Mouse Toxicology Gene Chip[J];Carcinogenesis,Teratogenesis & Mutagenesis;2006-02
2 GAO Li-hong,AO Lin,HU Ran,LIU Jin-yi,CAO Jia (Department of Toxicology,Third Military Medical University,Chongqing400038,China);Effects of Tetracycline on Expression Profiles of Genes A-ssociated with Lipid Metabolism in Balb/c Mouse Liver[J];Carcinogenesis,Teratogenesis & Mutagenesis;2006-02
3 XIAO Ying, LI Lan-ying, ZHANG Rui, DAI Xiao-yan (School of Chemical Engineering and Technology, Sichuan University, Chengdu 610065, China);The nitric acid oxidation of carbon black surface to obtain the good dispersion[J];Material Science and Technology;2005-01
4 Liu Wen ju; Zhang Xike; Tan Junpu; Liu CangZhen; Li Rengang(School of Agronomy, HAU, Baoding 071001)Zhang Fusuo(Department of Plant Nutrition, CAU, Beijing 10094);The Effect of P in Nutrient Solution on Cd Accumulated by Rice Shoot in the Seedling Stage[J];JOURNAL OF AGRICULTURAL UNIVERSITY OF HEBEI;1998-04
5 WANG Na,CHEN Guo xiang,SHAO Zhi guang, LIU Shuang,Wu Guo rong,LU Chang mei (College of Life Science,Nanjing Normal University,Nanjing 210097,China);Physiological studies on poisoning effects of Cd on Hydrocharis asiatica through inhibition of Pi[J];Acta Botanica Boreali-occidentalia Sinica;2001-06
6 WU Ya zhou 1, ZHANG Yan qi 1, HUANG Ming hui 2, YANG Meng su 3, ZENG Zhi xiong 3, YI Dong 1 ( 1Department of Health Statistics, College of Preventive Medicine, Third Military Medical University, Chongqing 400038; 2Shenzhen Institute, City University of Hong Kong, Shenzhen 518057, China; 3Applied Research Center for Genomics Technology, City University of Hong Kong, Hong Kong);Normalization and analysis of expression data of gene chips[J];Acta Academiae Medicinae Militaris Tertiae;2004-07
7 WU Yong-gui1,2,Xiong Yan1,LIN Chu-xia2(1.College of Resources and Environmental Engineering,Guizhou University,Guiyang 550003;2.College of Resources and Environment,South China Agricultural University,Guangzhou 510642).;ASSESSING THE JOINT-BIOTOXICITY OF THE DIFFERENT LEVELS OF PHOSPORUS ON HEAVY METALS IN WATER BY THE PHOTOTACTIC BEHAVIOR OF DAPHNIA[J];Guizhou Science;2007-S1
8 Chen Shibao 1,2 Zhu Yongguan 1\ Yang Juncheng 2 (1. Research Center for Eco_Environmental Sciences, Chinese Academy of Sciences, Beijing 100085; 2. Institute of Soil and Fertilizer, Chinese Academy of Agricultural Sciences, Beijing 100094);Mechanism of the effect of phosphorus on bioavailability of heavy metals in soil-plant systems[J];Techniques and Equipment for Environmental Pollution Control;2003-08
9 Wang Haiou~(1,2) Liu Jiemin~1 Gong Aijun~1 Lu Junjun~1 Hong Minjie~1 Shi Guoqing~1(1.Department of Biological Science & Technology,University of Science and Technology Beijing,Beijing 100083;2.State Key Laboratory of Environmental Chemistry and Ecotoxicology,Research Center for Eco-Environmental Sciences,Chinese Academy of Sciences,Beijing 100085);Wheat response to copper induced oxidative stress under different phosphate treatments[J];Techniques and Equipment for Environmental Pollution Control;2006-05
10 CHEN Zhangliu, YANG Guixiang, SUN Yongxue, HUANG Xianhui, ZENG Zhenling (Dept. of Veterinary Medicine, South China Agric. Univ., Guangzhou 510642, China);Advance of Toxicities and Ecotoxicology of Veterinary Drug Residues[J];Journal of South China Agricultural University;2001-01
【Secondary References】
Chinese Journal Full-text Database 5 Hits
1 ZHAO Chun,DENG Hui-ping,SHANG Ran(Key Laboratory of Yangtze River Water Environment,Ministry of Education,Shanghai 200092,P.R.China);Removal of Oxytetracycline in Water by Improved UV Disinfection Process[J];Journal of Civil,Architectural & Environmental Engineering;2009-02
2 YANG Le1,LIU Ying1,2 (1.College of Life and Environmental Science,Minzu University of China,Beijing 100081,China;2.College of Chemistry and Environmental Science,Inner Mongolia Normal University,Hohhot 010022,China);Determination of Metacycline Based on the SOR Fluorescent Microscopic Technique[J];Journal of Inner Mongolia University;2010-01
3 ZHAO Chun,DENG Huiping(Key Laboratory of Yangtze River Water Environment of the Ministry of Education,Tongji University,Shanghai 200092,China);Removal of Oxytetracycline in Water by UV/Hydrophobic Zeolite Loaded with TiO_2[J];Journal of Tongji University(Natural Science);2009-10
4 LIU Yinping, ZHU Lingyan, LI JingguangCollege of Environmental Science and Engineering, Nankai University, Tianjin 300071, China;Research progress of pharmaceutical and personal care products on ecological and human health[J];Journal of Hygiene Research;2009-02
5 YAO Li,JIN Qiu-yue,XIE Hong,et al;Application of gene chip in drug study[J];Acta Academiae Medicinae CPAF;2009-07
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved