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《Acta Academiae Medicinae Militaris Tertiae》 2006-07
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Effect of icariin on expression of cytochrome C oxidase subunit Ⅱ mRNA in mice of cerebral ischemia/reperfusion

LI Li~ 1 , ZHOU Qi-xin~ 1 , SHI Jing-shan~ 2 (~ 1 Research Center of Biochemistry and Molecular Pharmacology, Chongqing University of Medical Sciences, Chongqing 400016, ~ 2 Department of Pharmacology, Zunyi Medical College, Zunyi 563003, China)  
Objective To evaluate the effects of cerebral ischemia/reperfusion or/and icariin on expression of cytochrome C oxidase subunitⅡ(COⅡ) mRNA in mice. Methods The mouse model of transient cerebral ischemia/reperfusion was made by bilateral occlusion of common carotid arteries and ischemic hypotension/reperfusion. The mice were divided into several groups at random: normal control group, model group and icariin preventive treatment group (100 mg/kg). The changes in expression levels of COⅡ mRNA in mice cerebral tissue were detected by RT-PCR at different time points. Results The levels of CO Ⅱ mRNA in model group had no significant changes at 1 h and 24 h after cerebral ischemia/reperfusion as compared with that in control group, but decreased remarkably at 3 h (P0.01), and COⅡ mRNA in the icariin preventive treatment group had no significant changes. At 72 h after cerebral ischemia/reperfusion CO Ⅱ mRNA in model group significantly increased (P0.01), while pre-treatment with icariin blunted its increasing (P0.05). CO Ⅱ mRNA in model group dropped at 14 d (P0.05), and pre-treatment with icariin blunted its decreasing. Conclusion Cerebral ischemia/reperfusion can affect mRNA expression of CO Ⅱ. The pre-treatment with icariin can maintain the expression of CO Ⅱ mRNA, indicating the possible mechanism of the neuroprotective effects of icariin.
【Key Words】： cerebral ischemia/reperfusion cytochrome oxidase gene expression icariin
【Fund】： 重庆医科大学科技基金资助项目(XB200327)~~
【CateGory Index】： R285.5
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