Clinical study of oxiracetam for mild or medium brain injury
ZHU Ji (Department of Neurosurgery, The First Affiliated Hospital, Chongqing University of Medical Sciences, Chongqing 400016, China)
Objective To study and evaluate the effect of oxiracetam on brain injury. Methods Totally 60 patients with mild or medium brain injury were randomly assigned to receive oxiracetam or piracetam as control. MMSE and WMS scales were used to evaluate the therapeutic effects. Results The t value of MMSE and WMS was 15.85 and 5.97 in the oxiracetam group and 6.17 and 3.77 in the control group, with a significant difference between two groups (P0.01). In the oxiracetam group, good curative effect was achieved in 12 cases (40%), fair effect in 16 cases (53%), and the total effective rate was 93%. In the control group, good curative effect was achieved in 8 cases (27%), fair effect in 12 cases (40%), and the total effective rate was 63%. The outcome was significantly different between the two groups (χ2=7.20, P0.01). Conclusion Oxiracetam and piracetam are effective in the treatment of mild and medium brain injury, but oxiracetam is superior to piracetam.