Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Acta Academiae Medicinae Militaris Tertiae》 2006-16
Add to Favorite Get Latest Update

Histopathologic comparison between PS1/APP double transgenic mouse model and Aβ_(1-40)-injected rat model of Alzheimer disease

LI Da-bing 1 , TANG Jun 1 ,FAN Xiao-tang 2 ,SONG Min 3 ,XU Hai-wei 1 ,ZHOU Guang-ji 1 ,BAI Yun 3 ( 1 Department of Physiology, 2 Department of Neurobiology, 3 Department of Medical Genetics,College of Medicine,Third Military Medical University,Chongqing 400038,China)  
Objective To identify the genetype of the PS1/APP double transgenic mouse model,then to analyse the histopathological changes in the brain and compare the differences between the transgenic mice models and Aβ_(1-40)-injected rat model of Alzheimer disease. Methods The improved congo red staining,Nissl’s staining and immunohistochemical staining was used to observe the Aβ deposits,activation of astrocyte respectively. Results The PS1/APP transgenic mouse extensively displayed Aβ deposits in the cortex and hippocampal structures,and GFAP positive cells were aggregated in mass and surrounded the congo red-positive plaque. The Aβ_(1-40)-intrahippocampal-injected rat model showed the Aβ plaque deposits in the dentate gyrus of the hippocampus,with the astrocyte surrounded. The neuron loss was significant in the injection point and pin hole of injection with Nissl’s staining methods. GFAP-positive cells increased significantly as compared with the uninjured lateral of the hippocampus. Conclusion Although Aβ_(1-40)-injected rat models simulate some characteristic pathological features of human Alzheimer diseases,it would not simulate the progressive degenenration in the brain of AD. The double transgenic PS1/APP mice could simulate the specific pathogenesis and progressive changes of AD,while no neuron loss was found in this model.
【Fund】: 国家自然科学基金海外青年学者合作研究基金资助项目(30228018);; 国家自然科学基金资助项目(30100087 30500148 30571770)~~
【CateGory Index】: R361
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 1 Hits
1 Chen Gui-fang1, Li Tian-dong1, Zhang Kai-fa2 1College of Life Science and Technology, 2College Hospital, Mianyang Normal University, Mianyang 621000, Sichuan Province, China;Neural stem cell transplantation for Alzheimer’s disease rats: Efficiency evaluation[J];Journal of Clinical Rehabilitative Tissue Engineering Research;2009-45
【Citations】
Chinese Journal Full-text Database 1 Hits
1 WU Xuan, XU Hai wei, LI Hai di, FAN Xiao tang, CAO Juan, TANG Jun (Department of Physiology, Third Military Medical University, Chongqing 400038, China);AANAT gene-engineered embryonic stem cells decrease the amyloid β secretion of APP-overexpressed PC12 cells[J];Acta Academiae Medicinae Militaris Tertiae;2003-03
【Co-citations】
Chinese Journal Full-text Database 4 Hits
1 ;Comparison of methods for culturing mouse embryonic stem cell line ES/GFP and its effect on cell proliferation and differentiation[J];Acta Academiae Medicinae Militaris Tertiae;2004-19
2 WANG Xiaoyue1,ZHOU Lisha2(1.Postgraduate student of Hubei College of Traditional Chinese Medicine,Wuhan,Hubei,430061;2.Medical College of Jiang Han University,Wuhan,Hubei,430065);Effects of Electroacupuncture on bFGF of AD Model Rat's Hippocampal Neural Stem Sells and Study Memory Ability[J];Journal of Hubei College of Traditional Chinese Medicine;2008-01
3 Chen Gui-fang1, Li Tian-dong1, Zhang Kai-fa2 1College of Life Science and Technology, 2College Hospital, Mianyang Normal University, Mianyang 621000, Sichuan Province, China;Neural stem cell transplantation for Alzheimer’s disease rats: Efficiency evaluation[J];Journal of Clinical Rehabilitative Tissue Engineering Research;2009-45
4 ZHAO Bao-sheng1,XU Tun-hai2(1.Experimental Center of Scientific Research,2.School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing 100029,China);Methods for Model Establishment of Alzheimer's Disease[J];Chinese Journal of Experimental Traditional Medical Formulae;2011-06
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 Yang Xianling Red Cross Taiwangnese Hospital,Xiangshan County,Zhejiang Province(315731);Review on Chinese Medicine Treating Senile Dementia[J];Journal of Zhejiang University of Traditional Chinese Medicine;2007-01
2 Zhang Xiaojie1,2 Niu Yingcai1 Xing Guihua1 Lin Chunrong1 Li Xueyan1 Li Pengtao2 (1 Institute of Pharmaceutical Research,Qiqihaer College of Traditional Chinese Medicine,Qiqihaer,161042;2 Basic Medical College,Beijing University of Traditional Chinese Medicine,Beijing 100029);Effect of Tongluo Jiunao Oral Solution on Learning and Memory and the Expression of AChE in Hippocampus of AD Rats[J];China Journal of Traditional Chinese Medicine and Pharmacy;2007-06
3 YUAN Ye-feng*, WAN Ai-lan*, CHENG Jian-yun*, CHAO Xue-lin*, HUANG Guo-ming*, ZHOU Xiao-jun, GUO Ming*, CHEN Xian-sheng, ZOU Guo-hua, LU Xiao-yong, ZHOU Ping-liang, WEI Bo, TU Yuan-liang. *Departmant of Psychiatry, Jiangxi Medical College, Nanchang 330006, China;Epidemiological report of senile dementia in Nanchang city[J];Chinese Journal of Neuromedicine;2005-01
4 YING Chun-yi*, CHEN Xi-gu, CHEN Ru-zhu*, WANG Xue-lan*. *Department of Pharmacology, Sun Yat-sen University, Guangzhou 510080, China;Tau protein related to neurodegenerative diseases and transgenic animal models[J];Chinese Journal of Neuromedicine;2005-01
5 FANG Fang ,YAN Yong ,FENG Zhan-hui ,et al. (Department of Neurology ,First Affaliated Hospital,Chongqing University of Medical Sciences,Key Laboratory of Neurology in Chongqing ,Chongqing 400016,China);Study of Alzheimier's disease animal model induced by multiple factors[J];Chongqing Medicine;2007-02
6 SONG Min~(1),TANG Jun~(2),LI Da-bing~(2),XU Hai-wei~(2),BAI Yun~(1)(~(1)Department of Molecular Genetics,~(2)Department of Physiology,College of Medicine,Third Military Medical University,Chongqing 400038,China);Genetype identification and histologic analysis of PS1/APP double transgenic Alzheimer disease mouse model[J];Acta Academiae Medicinae Militaris Tertiae;2006-14
7 TANG Jun~ 1 ,XU Hai-wei~ 1 , ZHOU Guang-ji~ 1 , FAN Xiao-tang~ 2 , LI Da-bing~ 1 ,YANG Li~ 1 (~ 1 Department of Physiology, ~ 2 Department of Neurobiology, College of Medicine, Third Military Medical University, Chongqing 400038, China);Differentiation of neural precursor cells derived from mouse embryonic stem cells after transplantation into Aβ injured rat hippocampus and the improvement in memory[J];Acta Academiae Medicinae Militaris Tertiae;2007-02
8 WU Qiang1, LI Lu-si1, FAN Wen-hui1, SONG Min2, YANG Zhong3 (1Department of Neurology, Southwest Hospital, 2Department of Medical Genetics, 3Department of Neurobiology, College of Medicine, Third Military Medical University, Chongqing 400038, China);Therapeutic effect of mouse embryonic neural stem cells replacement into hippocampus of APP/PS1 double transgenic mice of Alzheimer disease[J];Acta Academiae Medicinae Militaris Tertiae;2007-10
9 LI Zhi-fang1,2, TANG Jun2, LI Lu-si1, YANG Li2, XU Hai-wei2 (1Department of Neurology, Southwest Hospital, 2Department of Physiology, College of Medicine, Third Military Medical University, Chongqing 400038, China);Morphological observation of embryonic stem cell-derived neurons after transplanted into Aβ-injured rat hippocampus[J];Acta Academiae Medicinae Militaris Tertiae;2008-06
10 YAO Bo-chun, Sun Tian-min, Li Cong, et al. Institute of Basic Medical Sciences, YunYang Medical College, ShiYan 442000, China;Effects of distilled fluid of olfactory ensheathing cells on cholinergic nerve cells transplantion for the treatment of alzheimer's disease rat[J];Guangdong Medical Journal;2008-09
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 QIU Guan ting 1, HUANG Bing 2, TANG Shi bo 1, HU Jie 1, LIU Zhi xiong 1 (1. Vitreoretinal Laboratory, Zhongshan Ophthalmic Center, Guangzhou, 510060; 2. Experimental Animal Center, Sun Yat sen University of Medical Sciences, Guangzhou 510089,;The Investigation of Cell Culture Conditions Maintained Embryonic Stem Cells as Totipotent Cells[J];ACADEMIC JOURNAL OF SUN YAT-SEN UNIVERSITY OF MEDICAL SCIENCES;2000-02
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved