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《Acta Academiae Medicinae Militaris Tertiae》 2006-18
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Effect of borneol on levels of monoamine neurotransmitters in prefrontal cortex of rat after long-term continuous operations

XUE Li~(1),CHEN Xiao-wei~(1),FAN Hong-xiao~(1),FAN Shuang-yi~(1),LIANG Yu~(1),XIA Jian-xia~(2),ZHOU Hong~(3),HU Zhi-an~(1,2)(~(1)Experimental Center,~(2)Department of Physiology, ~(3)Department of Pharmacology,College of Medicine,Third Military Medical University,Chongqing 40038,China)  
Objective To investigate the effect of borneol on levels of monoamine neurotransmitters in the prefrontal cortex of rat after long-term continuous operations.Methods A rat model of long-term continuous operations were established by using a treadmill protocol.Then Borneol(0.4 g/kg,p.o.) was given to the rats after the operation,and their activity-rest behavior and active avoidance response were assessed.Two h later,the rats were sacrificed and the level of monoamine neurotransmitter in the prefrontal cortex was determined by high performance liquid chromatography combined with electrochemical detection(HPLC-ECD).Results After the administration of borneol,the activities of operational animals were increased markedly as compared with that of vehicle operational group.The operational rats after borneol application had less response time than the ones treated with vehicle(6.85±1.24) s in active avoidance response.The levels of monoamine neurotransmitters including noradrenaline,dopamine,and 5-serotonin in the prefrontal cortex were decreased after treadmill operation.While application of borneol made the levels of noradrenaline and 5-serotonin increased significantly as compared to operational group.Conclusion Borneol have a reversal effect on rat awake activity impairment after long-term continuous operations.And the arousal effects of borneol are associated with the increase of noradrenaline and 5-serotonin levels in the prefrontal cortex.
【Fund】: 第三军医大学军事医学创新科研基金资助项目(XJYY200310);; 全军“十一五”面上项目(06MA195)~~
【CateGory Index】: R285
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