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《Acta Academiae Medicinae Militaris Tertiae》 2007-01
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Performance assessment of decalcified bone matrix of goat as scaffold of bone tissue engineering

LI Qiang,HE Qing-yi,XU Jian-zhong,HOU Tian-yong,WANG Xu-quan,ZENG Lin,FENG Jiang-hua(Orthopedics Research Center,Southwest hospital,Third Military Medical University,Chongqing 400037,China)  
Objective To prepare completely decalcified bone matrix(DBM) and study its physical characteristics and biomechanical properties in order to afford theoretical base for DBM as ideal scaffold of bone tissue engineering.Methods Completely decalcified bone matrix from goat was prepared with the standard methods.Its physical characteristics including colour,texture,porosities were observed,and the hole diameter and porosity were detected under scanning electron microscope(SEM).The hydrophilicity of DBM was evaluated by calculating water absorption.Its transient recovery rate of deformation,complete recovery time of deformation and maximal compressive strength were determined with biomechanical approach.Results DBM is ivory white with unique density and redundant microporosities of which the average diameter is(409.2±39.7) μm.The maximum of absorption time and absorption rate of DBM were 12 h and(419.0±44.4)%.The transient recovery rate of deformation was 100% and(91.0±8.2)% when DBM is compressed 20% and 30% respectively.Conclusion The properties of DBM are larger diameter and higher rate of microporosities,better hydrophilicity,easy recover of deformation and more suitable for adhesiveness and growth of breeding cells,which is the ideal scaffold material of bone tissue engineering.
【Fund】: 国家高技术研究发展计划重大攻关课题(“863”计划)(2003AA205020);; 国家自然科学基金(30300357)~~
【CateGory Index】: R318.08
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