Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Acta Academiae Medicinae Militaris Tertiae》 2007-13
Add to Favorite Get Latest Update

Correlation of virus load to contents of serologic markers in HBV patients

TIAN Yi,TANG Xiao-peng,YANG Xu,LUO Kai-zhong,HUANG Li(Liver Diseases Research Center,The Second Xiangya Hospital,Central South University,Changsha 410011,China)  
Objective To explore the relationship between HBV load and the contents of serologic markers.Methods Time-resolved immunofluorometric assay(TRIFA) was used to detect the contents of HBV immunological markers and real-time fluorescent quantitative PCR(FQ-PCR) was used to measure the HBV DNA of 1 486 clinical serum samples.The data was analyzed by SPSS11.0.Results The HBsAg contents were extremely different in the same or different models of serologic markers.The HBV copies of HBeAg(+) patients were significantly more than HBeAb(+) and HBeAg(-)HBeAb(-) patients(P0.01),but without statistical significance between HBeAb(+) and HBeAg(-)HBeAb(-) patients(P0.05).The contents of both HBsAg and HBeAg were positively correlated with the load of HBV DNA(r=0.383,0.635,P=0.01),while HBeAb negatively correlated to it(r=-0.563,P=0.01).Direct correlation existed between the contents of HBsAg and HbeAg(r=0.466,P=0.01) while inverse correlation was observed between the contents of HBsAg and HbeAb(r=-0.524,P=0.01).Conclusion A certain correlation exists between the contents of serologic markers and DNA of hepatitis B but the great variance exists among individuals.Combining FQ-PCR with TRIFA method is profitable for judging the state of HBV viral replication roundly and provides scientific and reliable evidences for clinical decisions.
【CateGory Index】: R373
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 6 Hits
1 DENG Xin-xin,JIA Xing-wang,TIAN Ya-ping(Department of Biochemistry,General Hospital of PLA,Beijing 100853,China);The Survey of Infections Status of Hepatitis B during Physical Examination among 507 People[J];Labeled Immunoassays and Clinical Medicine;2008-06
2 TANG Ying-zi, CHEN Yao-kai, LIU Lin, DENG Guo-hong, WANG Yu-ming (Institute of Infectious Diseases, Southwest Hospital, Third Military Medical University, Chongqing 400038, China);Correlation factors involved in therapeutic efficacy of adefovir dipivoxil for chronic hepatitis B patients[J];Acta Academiae Medicinae Militaris Tertiae;2007-18
3 Tan Shun, Tan Wenting, Liu Ming, Mao Qing, Deng Guohong (Institution of Infectious Diseases, Southwest Hospital, Third Military University, Chongqing, 400038, China);Clinical characteristics of hepatitis A:report of 176 cases[J];Acta Academiae Medicinae Militaris Tertiae;2010-22
4 ZHENG Youwei,LIANG Minwen,QIAN Jinglin,et alDepartment of Pathology and Laboratory Medicine,GuangdongAcademy of Medical Science,Guangzhou 510080,China;Significance of COI Value of HBsAg and HBeAg During Monitoring of Efficacy of HBV Treatment[J];Journal of Medical Forum;2010-20
5 GUO Wanshen;LIU Qian;GUO Yonghao;DONG Pumei;FENG Xiuhong;XU Jin;YE Ying;LI Jun;ZHANG Yanyang,WANG Zhe,LIU Guohua Department of Immunization Program,Henan Center for Disease Control and Prevention;;Serological survey of hepatitis B among adult population in Henan[J];Journal of Zhengzhou University(Medical Sciences);2014-01
6 HUANG Fu-deng,LEI Shu-yong,CHEN Hai-yun.Guangxi Municipal Corps Hospital,Chinese People's Armed Police Forces,Nanning 530003,China;Correlation between HBeAg quantity and HBV DNA capacities in different age patients with chronic hepatitis B virus infection[J];Medical Innovation of China;2010-16
Chinese Journal Full-text Database 8 Hits
1 ZHAO Guoqiang 1), ZHANG Shijie 1), LIU Quanli 2), XU Huidan 3), CHEN Zongde 1) 1)Department of Microbiology and Immunology, College of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450052 2)Department of Microbiology,Luohe Medical Technological Academy, Luohe 462000 3)Department of Microbiology,Hygiene and Technical School of Huaiyang, Huaiyang 466700;Cloning of combining antigen of HBsAg and human parvovirus B19 and its expression in E. Coli[J];Journal of Zhengzhou University(Science Medical);2005-03
2 MAO Guoqiang, ZHU Chaomin, XU HongmeiDepartment of Infectious Diseases and Gastroenterology,Children's Hospital,Chongqing University of Medical Sciences, Chongqing 400014;Detection of mutation in core promoter in children at different status of serum HBeAg with chronic hepatitis B[J];Journal of Zhengzhou University(Medical Sciences);2006-02
3 MA Yanli,REN Wanhua,DONG Zhenfang,ZHU YuhuaDepartment of Hepatology,Shandong Provincial Hospital of Shandong University,Jinan 250021,China;Clinical and pathological relationship between the quantity of hepatitis B virus covalently closed circular DNA and chronic hepatitis B[J];Chinese Journal of Gastroenterology and Hepatology;2005-06
4 ZHANG Lining; CAO Yinglin; SONG Jing et al.(Shandong Medical University, Jinan 250012);The corelation between integration of HSV X, S, Pre-S, C gene snd the expression of oncogenes/tumorsupressor genes in primary hepatocellujar carcinoma[J];Chinese Journal of Hepatology;1999-03
5 YANG Xu, LUO Hongyu, ZHANG Yonghong, QIAN Huanying, ZENG Xiaobo, HUANG Li. Liver Disease Research Center, Xiangya Second Affiliated Hospital, Central South University, Changsha 410011, China;Relationship between the quantities of virus and the models of serologic markers in patients infected with HBV[J];Chinese Journal of Hepatology;2002-04
6 LU Hui,MA Li-xian, XU Wan-su, ZHANG Hui-yun, YU Li-jun, DUAN Hong-ying. Jinan Infectious Diseases Hospital, Jinan 250021, China;Quantitative detection of intrahepatic hepatitis B virus DNA in patients with chronic hepatitis B[J];Chinese Journal of Hepatology;2003-03
7 WAN Bao-mei,LIU Shu-jun,LIU Xin-jun,YIN Yam-ming,LI He-lou,TAN Yong-xing. Department of Infectious Diseases,The Affiliated Hospital of Taishan Medical College,Shandong Taian 271000,China;Significance of detecting HBV-DNA by the fluorescence quantitative PCR[J];Chinese Journal of Experimental and Clinical Virology;2004-02
8 LIU Jingzhong *, TAN Shuzhen, WU Yan, et al. *Basic Medical Reasearch Center Beijing Chaoyang Hospital, Affiliate of Capital University of Medical Sciences, Beijing 100020, P.R. China [;Detection of hepatitis B virus by fluorescence quantitative PCR[J];Chinese Journal of Microbiology and Immunology;2001-06
Chinese Journal Full-text Database 10 Hits
1 ZHAO Xue-lan ,WANG Yu-ming (Institute of Infectious Disease,Southwest Hospital, the Third Military Medical University,Chongqing 400038,China);Comparison between two methods of quantification of intrahepatic HBV DNA[J];Chongqing Medical Journal;2004-10
2 WU Li-juan,CHEN Wei,CAI Jin,et al.(1.Department of Clinical Laboratory Lab,Daping Hospital,Third Military Medical University,Chongqing 400042,China;2.Health Service,94923 Unit,PLA,Wuyishan,Fujian 354301,China;3.43th Branch,Navy 91126 Unit,PLA,Dalian,Liaoning 116041,China);Clinical retrospective investigation in relationship among HBV-DNA,HBV-SM and hepatic function analysis[J];Chongqing Medicine;2007-13
3 Shuai Xiaorong XiaQingyou Zhu Yong (The Key Sericultural Laboratory of Agriculrural Ministry,College of Sericulture & biotechnology Southwest Agricultural Univorsity ,Chongqing, 400716);Progress and Application of Quantitative PCR[J];Newsletter of Sericultural Science;2002-04
4 XIAO Xiao-guang1,LI Yan-lian1,WANG Jing1,QU Shu-xian2 (1.Department of Clinical Laboratory,the First Affiliated Hospital of Dalian Medical University,Dalian 116011,China;2.Key Laboratory of Medical Cellular and Molecular Biology,Dalian Medical University,Dalian 116044,China);Detection of HBV cccDNA of peripheral blood mononuclear cells in hepatitis B patients and its clinical significance[J];Journal of Dalian Medical University;2010-03
5 LI Jun-nan1,WANG Yu-ming2,SHI Chang-xu1,LIANG Zhi-qing1,CHANG Qing1,ZHANG Qin1,CHEN Li1(1Department of Obstetrics and Gynecology,2Institute of Infectious Diseases,Southwest Hospital,Third Military Medical University,Chongqing 400038,China);On HBV infection of trophoblastic cells in primary culture[J];Acta Academiae Medicinae Militaris Tertiae;2007-14
6 TAN Wen-ting, DENG Guo-hong, WANG Yu-ming, DAN Yun-jie, KUANG Xue-mei (Institution of Infectious Diseases, Southwest Hospital, Third Military Medical University, Chongqing 400038, China);HBV genotype distribution and its influences on progression of HBV-related chronic liver disease in Chongqing population[J];Acta Academiae Medicinae Militaris Tertiae;2008-24
7 Li Xiaoyong,Wen Huaikai,Tao Hongqun,et al.Department of Clinical Laboratory,Lucheng People's Hospital,Wenzhou(325000),China;Study on the Correlation Between the HBV DNA Load and the Content of HBV Large Envelope Protein(HBV-LP)[J];Journal of Radioimmunology;2009-05
8 Gong Li-min1,Le Ai-ping2 1 Ningbo Municipal First Hospital,Ningbo (315010),China 2 The First Affiliated Hospital of Nanchang University,Nanchang (330006),China;Clinical Usefulness of Combined Determination of Serum HBV-LP and HBV-DNA in Patients with Hepatitis B[J];Journal of Radioimmunology;2010-05
9 LUO BinFeng DENG RuiLian LIU Hui YE JinJingThe ShiLong Peope’s hospital of DongGuang,GuangDong,523321;Measure Hepatitis B Patient Serum of HBV DNA Content and Probe into Their Clinical Meanings[J];International Medicine & Health Guidance News;2004-08
10 CHEN Kai-jie,ZHONG Qiong,YUAN Han-yao,et al. (1.Laboratory Department,2.Infectious Deapartment,The Affiliated Hospital of Guangdong Medical College,Guangdong Zhanjiang 524001,China);Detection and Clinical Significance of Hepatitis B Virus Large Surface Protein[J];International Journal of Laboratory Medicine;2010-07
Chinese Journal Full-text Database 10 Hits
1 SHANG Li-li1,REN Kai-xiang2(1.Department of Infections Diseases,Bengbu Infections Diseases Hospital,Bengbu 233000;2.Department of Gastroenterology,Bengbu First People's Hospital,Bengbu 233000,China);Nucleic acid quantifying assay of hepatitis B virus and clinical significance[J];Journal of Bengbu Medical College;2007-05
2 HU Guo-mao, HU Zhang-xue (Beijing Chemclin Bio-tech INC, Beijing 100012, China);A New Chemiluminescent Immunoassay for Quantitative Determination of HBV Markers[J];Labeled Immunoassays and Clinical Medicine;2004-03
3 ZHU Ping-an, SHEN Qun-xi, ZHU Ling-ling, et al (Shenzhen Yantian District Hospital, Guangdong Shenzhen 518081,China);STUDY ON THE OPTIMAL DILUTION OF SERUM FOR QUANTITATIVE MEASURING LEVEL OF HEP ATITIS B SURFACE ANTIGEN BY ELECTROCHEMILUMINESCENCE IMMUNOASSAY[J];Journal of Chengde Medical College;2004-01
4 Cai Xiong; Wang Guojun; Qu Yao; Fan Chenghui; Zhang Ruiqi; Xu Wensheng (Department of Infectious Diseases, Changzheng Hospital, Second Military Medical University,Shanghai, 200003);Clinical efficacy of kurorinone in the treatment of chronic hepatitis B[J];Academic Journal of Second Military Medical University;1997-01
5 XU Wen-Sheng, WANG Guo-Jun, MIAO Xiao-Hui, CAI Xiong (Department of Infectious Diseases, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China);Effects of oxymatrine on expression of HBV DNA in HepG2.2.15 cells[J];Academic Journal of Second Military Medical University;2002-01
6 Liu Can,Weng Yirui,Chen Yongdong.Department of Clinical Laboratory,the First Affiliated Hospital of Fujian Medical University,Fuzhou 350004,China;Relationship between quantitative HBsAg by chemiluminescent immunoassay,HBV-DNA and HBV-M in patients with hepatitis B[J];Fujian Medical Journal;2006-04
7 Yang Yimin, Wang Shaobo, Xu XiaolingDepartment of Laboratory, HaiNing People’s Hospital, Hai Ning (314400);Clinical Application of Quantitative Determination of Hepatitis B Virus Markers(HBVM) with Electro-Chemiluminescence Immunoassay (ECLIA)[J];Journal of Radioimmunology;2005-01
8 Gao Yujin,Mei Cunjin,Liu Chengyong,et al.Hospital of Infectious Diseases and Hepatitis Research Institute,Xuzhou,Jiangsu,221004;Clinical significance and the relationship between HBV DNA quantity and special models of HBVM through quantity testing[J];Journal of Clinical Hepatology;2005-02
9 TANG Chao, ZHANG Xuewu. BoZhou People's Hospital, Bozhou, 236800,Anhui, China;Clinical study of lamivudine withdrawal hepatitis treated with oxymatrine[J];Journal of Clinical Hepatology;2007-03
10 ZHANG Wen-Yan~(1,2),WEI Jing-Yan~(1*),GUO Jie~(3),CHEN Gui-Qiu~(4),XING Cheng~(3),SHI Li-Hua~(5), YUAN Wei~(2),QIAN Li-Na~(2),QUE Xiao-Dong~(2),GAO Li~(2),LIU Meng-Hong~(2)(1.College of Pharmaceutical Science,Jilin University,Changchun 130021,China; 2.Jilin Province Center of Clinical Laboratory,Changchun 130021, China;3.College of Public Health,Jilin University,Changchun 130021,China; 4.China-Japan Union Hospital,Jilin University,Changchun 130031,China;5.Linjiang Hospital,Linjiang 134600,China);Studies on a Chemiluminescent Immunoassay with the Erythrocyte-labeled Antibody[J];Chemical Journal of Chinese Universities;2006-08
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 Zhang Xin①②,He Weiping②,Nie Weimin②,et al.①PLAPostgraduateMedicalSchool,Beijing100039,China.;Clinical study of adefovir dipivoxil for the treatment of HBeAg-positive chronic hepatitis B[J];Infectious Disease Information;2009-02
2 ;探讨阿德福韦酯联合双虎清肝颗粒抗肝纤维化指标肝纤四项复常率[J];Contemporary Medicine;2012-07
3 Wu Xin-yuan,Li Zhi-liang,Zhou ling-li,et al.(The Three Internal Medicine in the People's Hospital of Tongcheng of Hubei Province,Xianning 437400,China);The Efficacy of Adefovir Dipivoxil Combined with Hepatitis B Vaccine Cured Chronic Hepatitis B[J];Chinese Journal of Medicinal Guide;2010-12
4 Xiao Ji,Chen Wen,Liu Yuyuan,Wang Yuming(Institute of Infectious Diseases,Southwest Hospital,Third Military Medical University,Chongqing,400038,China);Analysis of factors related to lamivudine efficacy in treating HBeAg-negative chronic hepatitis B[J];Journal of Third Military Medical University;2011-08
5 Tang Yulan,Tan Wenting,Tan Shun,Gao Yan,Mao Qing,Deng Guohong(Institute of Infectious Diseases,Southwest Hospital,Third Military Medical University,Chongqing,400038,China);Epidemiological and clinical characteristics of sporadic hepatitis E:A report of 282 cases[J];Journal of Third Military Medical University;2011-11
6 MA Qiang1,HE An1,DONG Zhi-ning1,2,LIU Tian-cai1,ZOU Li-ping1,LIN Guan-feng1,LI Ming1,WU Ying-song1 1College of Biotechnology,Southern Medical University,Guangzhou 510515,China;2Guangzhou Darui Antibody Co.Ltd,Guangzhou 510663,China;Development of an amplified luminescent proximity homogeneous immunoassay kit for detecting human hepatitis B virus e antibody[J];Journal of Southern Medical University;2011-05
7 QIU Yuanwang,JIANG Xianghu,HUANG Lihua,et al. Infectious Disease Hospital,Wuxi 214000,Jiangsu,China;Correlation factors involved in therapeutic efficacy of adefovir dipivoxil in combination with lamivudine for chronic hepatitis B with YMDD mutation[J];Journal of Clinical Hepatology;2009-05
8 YE Jun,GAO Yufeng,WEI Yanyan,et al.Department of Hepatology,The Second Affiliated Hospital,Anhui Medical University,Hefei 230601,China Corresponding author:LI Xu,E-mail:aylixu@yahoo.com.cn;The efficacy of adefovir dipivoxil on patients with chronic hepatitis B and its association with HBV genotypes[J];Journal of Clinical Hepatology;2011-06
9 ZHENG Ling,PAN Chen,GAO Hai-bing [Fujian Medical University Teaching Hospital(Fuzhou Infection Diseases Hospital),Fuzhou 350025,China];Comparisons on efficacy and cost between two kinds of adefovir dipivoxil in 48 weeks treatment of chronic hepatitis B patients[J];Chinese Journal of Liver Diseases(Electronic Version);2010-01
10 CAI Shang-yuan,ZHANG Bing,YANG Xin-hong,ZHANG Xiao-li(Kaifeng Infectious Diseases Hospital,Kaifeng 475001,China);Efficacy on increased dose of adefovir dipivoxil to anti-HBV treatment in poor responded patients[J];Chinese Journal of Liver Diseases(Electronic Version);2012-02
China Proceedings of conference Full-text Database 1 Hits
1 Zheng Ling,PAN Chen,GAO Hai-bing.Fujian Medical University Teaching Hospital(Fuzhou Municipal Hospital of Infection),Fuzhou 350025,China;Comparision of efficacy and cost on two kinds of Adefovir dipivoxil in the 48 weeks treatment of chronic hepatitis B patients[A];[C];2011
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 PENG Jie, LUO Kang-xian, HOU Jin-lin, GUO Ya-bing, WANG Zhan-hui Department of Infectious Diseases, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China;Effects of partial deletion in the core promoter of hepatitis B virus genome on viral antigen ex-pressions[J];Journal of First Military Medical University;2002-04
2 HU Jun 1), QI Min 2), ZHANG Shijie 1), SONG Jianwei 3), ZHAO Guoqiang 1) 1)Department of Microbiology and Immunology, College of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450052 2)Department of Pharmacology, College of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450052 3)Experimental Center of Medical College, Zhengzhou University, Zhengzhou 450052;Construction of eukaryotic expression vector pcDNA3/VP2 and its immunological effect[J];Journal of Zhengzhou University(Science Medical);2005-03
3 ZHANG Guang - shu, ZHUO Hoi - long, XU Chuan -zhen, et al. ( The 88t/t Hospital of PLA, Institute ofLiver Disease, TaianCity, Shandong Province 271000);Significance of quantification assay of HBVDNA in liver tissue[J];Chinese Journal of Clinical Hepatology;2003-02
4 LI Jin ming,DENG Wei,WANG Lu nan, et al. (National Center for Clinical Laboratory);Suitability of weak positive quality control serum for hepatitis B virus DNA detection by polymerase chain reaction[J];JOURNAL OF CLINICAL LABORATORY SCIENCE;2000-01
6 Sun Wensheng; Zhang Lining; Cao Yinglin; et al(Dept. of Microbiology, Shandong Medical University);THE RELATIONSHIP RESEARCH OF HBV GENE TYPE WITH THE PREDICTION OF HBPATOCARCINOMA[J];ACTA ACADEMIAE MEDICINAE SHANDONG;1995-03
7 Sun Wensheng, Gao Fengguang, Cao Yinglin, et al. Shandong Medical University, Jinan 250012;A study on integration of HBV DNA and HBx subfragment in hepatocellular carcinoma[J];CHINESE JOURNAL OF INFECTIOUS DISEASES;1997-02
8 Zhang Fuchun,Wu Wanfen,Dong Huiqing,et al.Guangzhou 8th People's Hospital ,Guangzhou 510060;Detection of serum HBV DNA by quantitative PCR and its clinical application[J];CHINESE JOURNAL OF INFECTIOUS DISEASES;1997-01
9 XU Hongmei, REN Hong, QING Yuling, PENG Mingli, LING Ning. Research Institute of Viral Hepatitis, Chongqing 400010, China;Relationship between the different replication status of HBV and mutations in core promoter in mother and children infected by mother-to-infant transmission[J];Chinese Journal of Hepatology;2002-05
10 LU Hui,MA Li-xian, XU Wan-su, ZHANG Hui-yun, YU Li-jun, DUAN Hong-ying. Jinan Infectious Diseases Hospital, Jinan 250021, China;Quantitative detection of intrahepatic hepatitis B virus DNA in patients with chronic hepatitis B[J];Chinese Journal of Hepatology;2003-03
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved