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《Acta Academiae Medicinae Militaris Tertiae》 2007-13
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Correlation of virus load to contents of serologic markers in HBV patients

TIAN Yi,TANG Xiao-peng,YANG Xu,LUO Kai-zhong,HUANG Li(Liver Diseases Research Center,The Second Xiangya Hospital,Central South University,Changsha 410011,China)  
Objective To explore the relationship between HBV load and the contents of serologic markers.Methods Time-resolved immunofluorometric assay(TRIFA) was used to detect the contents of HBV immunological markers and real-time fluorescent quantitative PCR(FQ-PCR) was used to measure the HBV DNA of 1 486 clinical serum samples.The data was analyzed by SPSS11.0.Results The HBsAg contents were extremely different in the same or different models of serologic markers.The HBV copies of HBeAg(+) patients were significantly more than HBeAb(+) and HBeAg(-)HBeAb(-) patients(P0.01),but without statistical significance between HBeAb(+) and HBeAg(-)HBeAb(-) patients(P0.05).The contents of both HBsAg and HBeAg were positively correlated with the load of HBV DNA(r=0.383,0.635,P=0.01),while HBeAb negatively correlated to it(r=-0.563,P=0.01).Direct correlation existed between the contents of HBsAg and HbeAg(r=0.466,P=0.01) while inverse correlation was observed between the contents of HBsAg and HbeAb(r=-0.524,P=0.01).Conclusion A certain correlation exists between the contents of serologic markers and DNA of hepatitis B but the great variance exists among individuals.Combining FQ-PCR with TRIFA method is profitable for judging the state of HBV viral replication roundly and provides scientific and reliable evidences for clinical decisions.
【CateGory Index】: R373
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