Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Acta Academiae Medicinae Militaris Tertiae》 2008-10
Add to Favorite Get Latest Update

Experimental chronic hydrocephalus after intraventricular hemorrhage in rats:establishment of animal model and pathological observation

GONG Guo-qi,MENG Hui,XIA Yong-zhi,FENG Hua(Department of Neurosurgery,Southwest Hospital,Third Military Medicine University,Chongqing 400038,China)  
Objective To establish the rat model of chronic hydrocephalus after intraventricular hemorrhage(IVH).Methods Totally 110 Sprague Dawley female rats were divided into 3 groups:IVH group(n=50),saline control group(n=50)and the normal group(n=10).The rats in IVH group were infused autologous whole blood(130 μl)into the right lateral cerebral ventricle.All rats except the normal group were sacrificed on day 1,3,7,14,28 after operation,and the transverse diameter of the lateral ventricle was measured to evaluate hydrocephalus and the index of ventricle.The pathological changes of the brain were observed.Results Hydrocephalus occurred in 7 out of 10 rats in IVH group at 28 d.The index of ventricle in IVH group(4.51±1.94)was higher than that of saline control group(1.05±0.41)and the normal group(0.79±0.49)(P0.05).In the brain of the rats in the IVH group,we observed edema of white matter surrounding ventricle,twist and engorge of callosum,proliferation of rhagiocrine cells in 24,72 h after operation,absence of ciliums and microvillares of the ependymal cells on day 28.No similar changes occurred in the other two groups.Conclusion Injecting autologous blood into right lateral cerebral ventricle can produce chronic hydrocephalus similar to hydrocephalus after intraventricular hemorrhage.
【Fund】: 国家“十一五”科技攻关项目(2006BAI01A12)~~
【CateGory Index】: R-332
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 1 Hits
1 GONG Guo-qi,MENG Hui,FENG Hua (Department of Neurosurgery,Southwest Hospital,Third Military Medicine University,Chongqing 400038,China);Role of iron ion in development of hydrocephalus in rats[J];Acta Academiae Medicinae Militaris Tertiae;2008-23
【Citations】
Chinese Journal Full-text Database 2 Hits
1 DAI Jiong LI Shan-quan, LI Xiao-xiong XU Bin-bin XIONG Wen-hao,WANG Yong,ZhANG Xiao-hua Department of Neurosurgery, Renji Hospital, SSMU, Shanghai 200001, China SHEN Jia-lin Department of Radiology, Renji Hospital, SSMU, Shanghai 200001, China;MECHANISM OF PATHOLOGICAL CHANGES OF INTRAVENTRICULAR HEMORRHAGE IN DOGS[J];上海第二医科大学学报(英文版);2004-01
2 MENG Hui,ZHANG Lijun,LU Jiayou,et al Department of Neurosurgery,the PLA Army Minimally Invasive Treatment of Nervous System Diseases Specialist Centers,Southwest Hospital,Third Military Medicine University,Chongqing 400038,China;Levels and their significance of PⅠCP,PⅢNP,HA and laminin in cerebrospinal fluid in posthaemorrhagic chronic hydrocephalus[J];Chinese Journal of Minimally Invasive Neurosurgery;2007-02
【Co-citations】
Chinese Journal Full-text Database 3 Hits
1 GONG Guo-qi,MENG Hui,FENG Hua (Department of Neurosurgery,Southwest Hospital,Third Military Medicine University,Chongqing 400038,China);Role of iron ion in development of hydrocephalus in rats[J];Acta Academiae Medicinae Militaris Tertiae;2008-23
2 MENG Hui,ZHANG Lijun,WANG Junwei,DENG Congying,FENG HuaDepartment of Neurosurgery,Southwest Hospital,Third Military Medical University,Chongqing 400038,China;The expressions of laminin and laminin receptor 1 in rat brains after experimental intraventricular hemorrhage[J];Chinese Journal of Neurosurgical Disease Research;2008-05
3 LI Lin-yong,LIU Fei,YAN Hui,et al. (Department of Neurosurgery,The Third Xiangya Hospital,Zhongnan University,Changsha 410013,China);On the change and their significance of the levels of PICP and PⅢNP in CSF of rats after SAH[J];Modern Medicine & Health;2008-07
【Co-references】
Chinese Journal Full-text Database 4 Hits
1 YANG Zhen, LUO Hai-ji, LU Xiao-cui, DENG Hong, KONG Liang(Department of Nutrition and Food Hygiene, Southern Medical University, Guangzhou 510515,China);Establishment of A Rat Model with Iron Deficiency Anemia(IDA)and A Survey on the IDA Related Indexes[J];Journal of Tropical Medicine;2006-03
2 Li Lin, Wu Jianliang, Jin Zheng, Dou Yan (Geratology Institute, Shanxi Medical University, Taiyuan 030001);HIGH CONCENTRATION OF IRON IN CEREBROSPINAL FLUID OF RATS INDUCES ALZHEIMER-LIKE BEHAVIORAL AND PATHOLOGICAL CHANGES[J];Chinese Journal of Neuroanatomy;2005-03
3 YU Huiling, WANG luning, MA Zhizhong,et al. Department of Neurology,PLA General hospital, Beijing 100853;The computerassisted area measurement of the brain volume on CT films in healthy aged individuals[J];CHINESE JOURNAL OF NEUROLOGY;1999-03
4 MENG Hui,ZHANG Lijun,LU Jiayou,et al Department of Neurosurgery,the PLA Army Minimally Invasive Treatment of Nervous System Diseases Specialist Centers,Southwest Hospital,Third Military Medicine University,Chongqing 400038,China;Levels and their significance of PⅠCP,PⅢNP,HA and laminin in cerebrospinal fluid in posthaemorrhagic chronic hydrocephalus[J];Chinese Journal of Minimally Invasive Neurosurgery;2007-02
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved