Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Acta Academiae Medicinae Militaris Tertiae》 2008-14
Add to Favorite Get Latest Update

Effect of continuous dynamic pressure stress on cyclooxygenase mRNA expression,bone mass and mechanical properties during fracture healing process in rabbits

REN Ke1,ZHANG Chun-cai2,WANG Guang-ye2,ZHANG Jun-jie1,ZHAO Jian-ning1,LI Bo2 (1Department of Orthopaedics,Nanjing General Hospital of Nanjing Command,Nanjing 210002; 2Department of Orthopaedics,Changhai Hospital,Second Military Medical University,Shanghai 200433,China)  
Objective To explore the effect of continuous dynamic pressure on cyclooxygenase mRNA expression,bone mass and mechanical properties during experimental fracture healing. Methods Unilateral osteotomy of left humeral diaphysis was performed on adult New Zealand rabbits. The humeral fracture was fixed by shape memory connector (SMC) in Study Group and by 4-hole dynamic compression plate (DCP) in Control Group. Samples from the fracture gaps were obtained on day 3,7,14,21,28 and 56 and the temporal expression patterns of cyclooxygenase mRNA during the healing process were examined by real-time PCR. The humeri were harvested and sent for biomechanical tests as well as dual-energy X-ray absorptiometry in 2,4,8 and 12 weeks postoperatively. Results The relative levels of COX-2 mRNA were elevated after fracture and were significantly higher in Study Group than in Control Group at 3 and 4 weeks postoperatively. The BMD values of the Study Group were significantly higher than those in the Control Group from 4 to 12 weeks postoperatively. With regard to bone mechanical parameters,the Study Group showed significantly higher maximum torque,torsional stiffness,bending strength and bending rigidity than those in the Control Group at 4 and 8 weeks postoperatively. Conclusion The persistent dynamic longitudinal pressure produced by SMC may accelerate bone healing with increased bone mass and bone strength after fractures in this rabbit model by promoting the proliferation activity of the osteoblasts and callus mineralization,which may be closely related with a higher COX-2 mRNA expression.
【CateGory Index】: R318.01
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【Citations】
Chinese Journal Full-text Database 2 Hits
1 ZHANG Chun Cai 1, XU Shuo Gui 1, WANG Jia Lin 1, YU Bao Qing 1, WANG Qiu Gen 1, ZHANG Qiu Lin 1, LIANG Yu Tian 2, WANG Ren 3 (1. Department of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai 200433, China; 2. D;Design and clinical application of swan-like memory compressive connector for upper limb diaphysis[J];Academic Journal of Second Military Medical University;2001-10
2 XU Shuo Gui 1, ZHANG Chun Cai 1, SU Jia Can 1, LIU Xiao Hua 2, WU Yi Nong 2, WU Jian Guo 3, XUE Zhao Jun 3, DING Zu Quan 3 (1. Department of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai 200433, China; 2. Sha;Three-dimensional element analysis of swan-like memory compressive connector for treating fractures and nonunion of humerus[J];Academic Journal of Second Military Medical University;2001-10
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 ZHANG Chun Cai 1, XU Shuo Gui 1, WANG Jia Lin 1, YU Bao Qing 1, WANG Qiu Gen 1, ZHANG Qiu Lin 1, LIANG Yu Tian 2, WANG Ren 3 (1. Department of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai 200433, China; 2. D;Design and clinical application of swan-like memory compressive connector for upper limb diaphysis[J];Academic Journal of Second Military Medical University;2001-10
2 YAN Wang Jun 1, ZHANG Chun Cai 1, ZHANG Xue Song 1, SHEN Hong Xing 1, WANG Jia Lin 1, XU Shuo Gui 1, ZHANG Li Min 2, ZHU Zhi 3, SU Jia Can 1 (1. Department of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai 2;Ultrastructural study on effects of swan-like memory compressive connector on bone healing[J];Academic Journal of Second Military Medical University;2001-10
3 SU Jia-Can,YU Bao-Qing,ZHANG Chun-Cai ,XU Shuo-Gui ,WANG Jia-Lin,JI Fang ,XUE Zhao-Jun,WU Jian-Guo DING Zu-Quan, HOU Tie-Sheng(1. Department of Orthopedics ,Changhai Hospital, Second Military Medical University, Shanghai 200433, China; 2. Institute of Life Science and Bioengineering.Tongji University, Shanghai 200092);Mechanical stability of anatomic distal radius Ni-tinol memory connector[J];Academic Journal of Second Military Medical University;2003-11
4 GAO Tang Cheng 1,ZHANG Chun Cai 1* ,KANG Qing Lin 1,XU Shuo Gui 1,NI Can Rong 2,WANG Zhi Wei 1, FU Qing Ge 1 (1. Department of Orthopaedics, Changhai Hospital, Second Military Medical University,Shanghai 200433,China; 2. Department of Pathology, Changhai Hospital);Expression of TGF-β in fracture fixed by swan-like memory-compressive connector[J];Academic Journal of Second Military Medical University;2004-03
5 SU Jia Can 1,ZHANG Chun Cai 1* ,WANG Jia Lin 1,YU Bao Qing 1,JI Fang 1,XU Shuo Gui 1,CHEN Xue Qiang 2,WU Jian Guo 2,DING Zu Quan 2(1. Department of Orthopaedics,Changhai Hospital,Second Military Medical University,Shanghai 200433,China; 2. Institute of Life Science and Bioengineering,Tongji University,Shanghai 200092);Construction of three-dimensional finite element acetabular model[J];Academic Journal of Second Military Medical University;2004-03
6 GAO Tang-Cheng 1,ZHANG Chun-Cai 1* ,KANG Qing-Lin 1,NI Can-Rong 2,WANG Zhi-Wei 1,XU Shuo-Gui 1,SHEN Hong-Xing 1 (1.Department of Orthopedics,Changhai Hospital,Second Military Medical University,Shanghai 200433,China; 2.Department of Pathology,Changhai Hospital);Effect of sustained compressive stress on content of IGF-Ⅰ and osteocalcin at experimental fracture sites in rabbits[J];Academic Journal of Second Military Medical University;2004-11
7 REN Ke~(1), ZHANG Chun-cai~(1*), KANG Qing-lin~(2), XU Shuo-gui~(1), GAO Tang-cheng~(1) (1. Department of Orthopaedics, Changhai Hospital, Second Military Medical University, Shanghai 200433, China;2. Department of Orthopaedics, Shanghai Sixth People's Hospital, Shanghai Jiaotong University,Shanghai 200233);Influence of Swan-like memory connector on osteopontin and osteonectin mRNA expression during experimental fracture healing[J];Academic Journal of Second Military Medical University;2005-09
8 ;Anatomic memory connector for treating nonunion of proximal ulna[J];Academic Journal of Second Military Medical University;2007-10
9 KANG Qing lin, ZHANG Chun cai, GAO Tang cheng (Department of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai 200433, China);Effects of swan-shaped memory connector on bone mineral density and mechanical properties of humeral fracture in rabbits[J];Acta Academiae Medicinae Militaris Tertiae;2003-22
10 REN Ke, ZHANG Chun Cai, XU Shuo Gui, TANG Hao, KANG Qing Lin, GAO Tang Cheng, ZHANG Xue Song Department of Orthopaedics, Changhai Hospital, Second Military Medical University, Shanghai 200433, China;Effect of continuous dynamic compressive stress on femoral fractures healing in dogs[J];Journal of The Fourth Military Medical University;2004-01
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 XU Shuo Gui 1, ZHANG Chun Cai 1, SU Jia Can 1, LIU Xiao Hua 2, WU Yi Nong 2, WU Jian Guo 3, XUE Zhao Jun 3, DING Zu Quan 3 (1. Department of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai 200433, China; 2. Sha;Three-dimensional element analysis of swan-like memory compressive connector for treating fractures and nonunion of humerus[J];Academic Journal of Second Military Medical University;2001-10
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved