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《Acta Academiae Medicinae Militaris Tertiae》 2008-23
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Role of iron ion in development of hydrocephalus in rats

GONG Guo-qi,MENG Hui,FENG Hua (Department of Neurosurgery,Southwest Hospital,Third Military Medicine University,Chongqing 400038,China)  
Objective To investigate the roles of iron ion in the development of experimental hydrocephalus in rats. Methods Seventy-five Sprague-Dawley female rats were divided into 3 groups randomly,that is,the iron group,the semi-iron group and the artificial cerebrospinal fluid (CSF) control group. FeC13 of 5 μl dissolved in artificial CSF with the concentration of 6.67 g/L and 3.33 g/L were slowly infused into the right lateral cerebral ventricle of the rats in the iron group and in the semis-iron group respectively. The rats in the artificial CSF control group were infused 5 μl artificial CSF. The rats were sacrificed 1,14 and 28 d later to measure the transverse diameter of the lateral ventricle for the evaluation of hydrocephalus and the index of ventricle,and pathology of brain was also observed. Results There were significant difference of hydrocephalus between the iron group (9/10) and the semis-iron group(1/5) at 28 d (P0.01). The index of ventricle in iron group were higher than the semis-iron group and the artificial CSF control group (P0.01). Cellular proliferation surrounding ventricle,edema of choroid plexus,deposit of haemosiderin,absence of ciliums and microvillares of the ependymal cells were observed in rats of the iron group. The pathological changes in the semis-iron group were milder than in the iron group. The artificial CSF control group showed no hydrocephalus. Conclusion Injecting higher concentration of iron into the lateral cerebral ventricle can produce hydrocephalus.
【Fund】: “十一五”国家科技支撑计划资助(2006BAI01A12)~~
【CateGory Index】: R742.7
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【Citations】
Chinese Journal Full-text Database 3 Hits
1 GONG Guo-qi,MENG Hui,XIA Yong-zhi,FENG Hua(Department of Neurosurgery,Southwest Hospital,Third Military Medicine University,Chongqing 400038,China);Experimental chronic hydrocephalus after intraventricular hemorrhage in rats:establishment of animal model and pathological observation[J];Acta Academiae Medicinae Militaris Tertiae;2008-10
2 Li Lin, Wu Jianliang, Jin Zheng, Dou Yan (Geratology Institute, Shanxi Medical University, Taiyuan 030001);HIGH CONCENTRATION OF IRON IN CEREBROSPINAL FLUID OF RATS INDUCES ALZHEIMER-LIKE BEHAVIORAL AND PATHOLOGICAL CHANGES[J];Chinese Journal of Neuroanatomy;2005-03
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【Co-citations】
Chinese Journal Full-text Database 3 Hits
1 GONG Guo-qi,MENG Hui,XIA Yong-zhi,FENG Hua(Department of Neurosurgery,Southwest Hospital,Third Military Medicine University,Chongqing 400038,China);Experimental chronic hydrocephalus after intraventricular hemorrhage in rats:establishment of animal model and pathological observation[J];Acta Academiae Medicinae Militaris Tertiae;2008-10
2 MENG Hui,ZHANG Lijun,WANG Junwei,DENG Congying,FENG HuaDepartment of Neurosurgery,Southwest Hospital,Third Military Medical University,Chongqing 400038,China;The expressions of laminin and laminin receptor 1 in rat brains after experimental intraventricular hemorrhage[J];Chinese Journal of Neurosurgical Disease Research;2008-05
3 LI Lin-yong,LIU Fei,YAN Hui,et al. (Department of Neurosurgery,The Third Xiangya Hospital,Zhongnan University,Changsha 410013,China);On the change and their significance of the levels of PICP and PⅢNP in CSF of rats after SAH[J];Modern Medicine & Health;2008-07
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Chinese Journal Full-text Database 2 Hits
1 DAI Jiong LI Shan-quan, LI Xiao-xiong XU Bin-bin XIONG Wen-hao,WANG Yong,ZhANG Xiao-hua Department of Neurosurgery, Renji Hospital, SSMU, Shanghai 200001, China SHEN Jia-lin Department of Radiology, Renji Hospital, SSMU, Shanghai 200001, China;MECHANISM OF PATHOLOGICAL CHANGES OF INTRAVENTRICULAR HEMORRHAGE IN DOGS[J];上海第二医科大学学报(英文版);2004-01
2 MENG Hui,ZHANG Lijun,LU Jiayou,et al Department of Neurosurgery,the PLA Army Minimally Invasive Treatment of Nervous System Diseases Specialist Centers,Southwest Hospital,Third Military Medicine University,Chongqing 400038,China;Levels and their significance of PⅠCP,PⅢNP,HA and laminin in cerebrospinal fluid in posthaemorrhagic chronic hydrocephalus[J];Chinese Journal of Minimally Invasive Neurosurgery;2007-02
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