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《Acta Academiae Medicinae Militaris Tertiae》 2009-07
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Relationship of matrix metalloproteinase-9 expression and angiogenesis in lung carcinoma and its significance

QIN Zhen1,LUO Bin2,WANG Xu-dong3(1Department of Respiratory Diseases,3Department of Pathology,Ninth People's Hospital of Chongqing City,Chongqing 400700;2Faculty of Clinical Medicine,Chongqing Medical and Pharmaceutical College,Chongqing 400051,China)  
Objective To investigate the relationship of matrix metalloproteinase-9(MMP-9)expression and angiogenesis in lung carcinoma tissue and its significance.Methods Totally 84 patients were subjected,including 40 cases of lung squamous cell carcinoma,34 of lung adenocarcinoma and 10 of small cell lung cancer.Twenty samples of normal adjacent tissues served as control.The expression of MMP-9 and CD34 was detected in these 104 lung tissue samples by immunohistochemical method.The expression of MMP-9 was analyzed with clinical pathological data and microvascular density(MVD).Results The expression of MMP-9 in lung carcinoma tissues was significantly higher than that in para-cancerous normal lung tissues(P0.01).Small cell lung cancer and adenocarcinoma had higher MMP-9 expression than squamous cell carcinoma(P0.01).The expression of MMP-9 was significantly higher in lung carcinomas with lymph node metastasis than in lung carcinomas without lymph node metastasis(P0.01),higher in stage-Ⅲ and-Ⅳ tumors than in stage-Ⅰ and-Ⅱ(P0.05).MVD was significantly higher in lung carcinomas with MMP-9 positive than in those negative(P0.01).Conclusion MMP-9 can improve the neovascularization of lung carcinoma,and is closely correlated with invasion and metastasis of lung carcinoma.
【Fund】: 重庆市卫生局科研基金(06-2-109)~~
【CateGory Index】: R734.2
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Chinese Journal Full-text Database 6 Hits
1 Jiang Zhong Qing, Zhu Feng Chuan, Qu Jun Ying, Zheng Xiu, You Cai LingDepartment of Obstetrics andGynecology,The Affiliated FirstHospital,Fujian Medical University,Fuzhou,Fujian,350005,P.R.China;Relationship between Expression of Matrix Metalloproteinase (MMP-9)and Tumor Angiogenesis,Cancer Cell Proliferation,Invasion,and Metastasis in Invasive Carcinoma of Cervix[J];Chinese Journal of Cancer;2003-02
2 ZHANG Yao,WU Xiao-hou,SUN Xiang-yu,et al.(1.Department of Urologic Surgery,People's Hospital of Suining City,Suining,Sichuan 629000,China;2.Department of Urology,First Affiliated Hospital,Chongqing University of Medical Sciences,Chongqing 400016,China);Expression and clinical significance of MMP-9,VEGF in renal cell carcinoma[J];Chongqing Medicine;2007-13
3 MEI Tong-hua 1, LUO Bin 1, MA Ying 2 ( 1Department of Respiratory Disease, 2Department of Pathology, Second Affiliated Hospital, Chongqing University of Medical Sciences, Chongqing 400010, China);Expressions of MMP-2, MMP-7 and TIMP-2 in lung carcinoma and their significance[J];Acta Academiae Medicinae Militaris Tertiae;2004-16
4 LIANG Jun, LIU Mingqiu, XIE Mei, LIU Xuan. Department of Nuclear Medicine, Wuhan University People Hospital, Wuhan, Hubei 430060, P.R.China;Expressions of matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1 and their correlation with metastasis and prognosis in lung cancer[J];Chinese Journal of Lung Cancer;2003-01
5 Gao Xia, Diao Luming, Li Heng, et al Dept. of Pathology, School of Medicine, Wuhan University,Wuhan 430071,China;Expression of c-Met Protein in Non-small Cell Lung Carcinoma and Its Relationship with Tumor Cell Proliferation and Angiogenesis[J];Journal of Hubei Medical University;2005-03
6 XUE Yang,ZHOU Qing-hua,ZHANG Shang-fu,et al.(1.The Department of Cardiothoracic Surgery,Sichuan Provincial People's Hospital,Chengdu,Sichuan 610072,China;2.The Department of Cardiothoracic Surgery,Tianjin Medical University General Hospital,Tianjin 300052,China;3.West China Hospital,Chengdu Sichuan 610041,China);A Study on the Relationship Between Expression of MMP-2,MMP-9 and Metastasis and Prognosis in Patients with Lung Cancer[J];West China Medical Journal;2008-02
Chinese Journal Full-text Database 9 Hits
1 Zhou Xu- Chun1, Tang Cheng- Wei2, Liu Chun- Lun1, Wang Chun- Hui2 1.Department of Gastroenterology, The First Affiliated Hospital, Chongqing University of Medical Sciences, Chongqing,400016, P.R.China 2.Department of Gastroenterology, West China Hospital,Sichuan University, Chengdu,Sichuan,610041, P.R.China;Effects of Rofecoxib on Angiogenesis of Pancreatic Cancer Xenograft in Nude Mice[J];Chinese Journal of Cancer;2004-04
2 Chun-Jie Li, Jian-Li Sun, Wei-Jie Jiang, Ling-Shuang Liu, Xi-Yuan Sun and Guo-Zhong Fan Third Division of Department of Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, P.R. China;Effect of cisplatin on expression of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 and their correlations in Lewis lung cancer in mice[J];Chinese Journal of Cancer;2009-07
3 TANG Chun-lan1, YANG He-ping1, BIAN Xiu-wu2, WANG Qing-liang2, ZHANG Rong2 (Department of Respiratory Diseases, 2Institute of Pathology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China);Clinicopathological significance of MMP-2 and MMP-9 expressions in non-small cell lung cancer:a tissue microarray study[J];Acta Academiae Medicinae Militaris Tertiae;2009-06
4 JIANG Xuege, ZHAO Po. Department of Pathology, General Hospital of Chinese People’s Liberation Army, Beijing 100853, P.R.China;Expression of c-kit protein and its significance in human small cell lung cancer[J];Chinese Journal of Lung Cancer;2004-03
5 WEN Hongtao 1),ZHANG Lei 2),LI Jichang 1),ZHANG Yunhan 2) 1)Department of Gastroenterology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052 2)Department of Pathology, the First Affiliated Hospital,Zhengzhou University;Henan Key Laboratory for Tumor Pathology, Zhengzhou 450052;Expression of matrix metalloproteinase-2,-9 in human esophageal cancer tissue[J];Journal of Zhengzhou University(Science Medical);2005-03
6 TAN Xian-jie, PAN Ling-ya(Department of Obstetrics and Gyncology, Peking Union Medical College Hospital, CAMS & PUMC, Beijing 100730,China);Advances in researches on angiogenesis and anti-angiogenictherapy in gynecologic tumors[J];Basic Medical Sciences and Clinics;2004-03
7 ZHAO Bin,HUANG Yun-chao (Dept. of Urinary Surgery,The 3rd Affiliated Hospital of Kunming Medical University,Kunming Yunnan 650118,China);The Relation between MMP-9 and Bladder Cancer[J];Journal of Kunming Medical University;2008-S1
8 CUI Hong-mei1, WANG Hai-lin2, WANG Xiao-li1,BAI Yan1(1Gansu Provincial Maternity and Childcare Hospital, Lanzhou 730000,China;2Department of Obsterics and Gynecology, the First Hospital of Lanzhou University, Lanzhou 730000, China);Expression of heparanase in cervical cancer and its correlation with metastasis and prognosis[J];Chinese Journal of Clinical and Experimental Pathology;2007-05
9 LUO Bin1,QIN Zhen2,WANG Xu-dong3 (1Faculty of Clinical Medicine,Chongqing Medical and Pharmaceutical College,Chongqing 400051,China;2Department of Respiratory Disease,the Ninth People′s Public Hospital in Chongqing City,Chongqing 400700,China;3Department of Pathology,the Ninth People′s Public Hospital in Chongqing City,Chongqing 400700,China);The relationship of MMP-9 and TIMP-1 expression with microvascular density in lung carcinoma and its significance[J];Chinese Journal of Clinical and Experimental Pathology;2009-05
【Secondary Citations】
Chinese Journal Full-text Database 2 Hits
1 LI Xiao chuan,WANG Yan qing (1.Department of General Surgery,Municipal Hospital of Qingdao,Shandong Provice,Qingdao 266011,China;2.Dpeartment of General Surgery,the First Affiliated Hospital,Chongqing University of Medical Sciences,Chongqing 400016,China);Expression of MMp_2、MMP_9 and PCNA in colorectal tumors and its clinical implication[J];Chongqing Medical Journal;2003-07
2 GE Ming jian, LI Liang bin, ZHANG Yu hong, WANG Mei (Department of Thoracic Surgery, First Affiliated Hospital, Chongqing University of Medical Sciences, Chongqing 400016, China);Prognostic significance of lymph node micrometastasis in patients with esophageal squamous carcinoma detected by RT-PCR[J];Acta Academiae Medicinae Militaris Tertiae;2003-17
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