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《Acta Academiae Medicinae Militaris Tertiae》 2009-07
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Relationship of matrix metalloproteinase-9 expression and angiogenesis in lung carcinoma and its significance

QIN Zhen1,LUO Bin2,WANG Xu-dong3(1Department of Respiratory Diseases,3Department of Pathology,Ninth People's Hospital of Chongqing City,Chongqing 400700;2Faculty of Clinical Medicine,Chongqing Medical and Pharmaceutical College,Chongqing 400051,China)  
Objective To investigate the relationship of matrix metalloproteinase-9(MMP-9)expression and angiogenesis in lung carcinoma tissue and its significance.Methods Totally 84 patients were subjected,including 40 cases of lung squamous cell carcinoma,34 of lung adenocarcinoma and 10 of small cell lung cancer.Twenty samples of normal adjacent tissues served as control.The expression of MMP-9 and CD34 was detected in these 104 lung tissue samples by immunohistochemical method.The expression of MMP-9 was analyzed with clinical pathological data and microvascular density(MVD).Results The expression of MMP-9 in lung carcinoma tissues was significantly higher than that in para-cancerous normal lung tissues(P0.01).Small cell lung cancer and adenocarcinoma had higher MMP-9 expression than squamous cell carcinoma(P0.01).The expression of MMP-9 was significantly higher in lung carcinomas with lymph node metastasis than in lung carcinomas without lymph node metastasis(P0.01),higher in stage-Ⅲ and-Ⅳ tumors than in stage-Ⅰ and-Ⅱ(P0.05).MVD was significantly higher in lung carcinomas with MMP-9 positive than in those negative(P0.01).Conclusion MMP-9 can improve the neovascularization of lung carcinoma,and is closely correlated with invasion and metastasis of lung carcinoma.
【Fund】: 重庆市卫生局科研基金(06-2-109)~~
【CateGory Index】: R734.2
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