Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Acta Academiae Medicinae Militaris Tertiae》 2009-14
Add to Favorite Get Latest Update

Effect of ginkgolide B on NF-κB expression in pulmonary tissue of mice with acute lung injury

LUO Zhen-chun1,HUANG Yan2,QIN Kai-xiu1,LING Zong-xiu1(1Department of Emergency,2Department of Anesthesiology,Second Affiliated Hospital,Chongqing Medical University,Chongqing 400010,China)  
Objective To investigate the effect of ginkgolide B(BN52021) on the NF-κB expression in pulmonary tissue of mice with LPS-induced acute lung injury.Methods Fifty Kunming mice were divided into 2 groups at random: LPS group(L group) and BN52021 pretreated group(B group),and then each group was subsequently divided into 5 subgroups according to different time point(0,1,3,9 and 12 h).The mice from corresponding groups received an intraperitoneal injection of normal saline or 20 mg/kg BN52021 followed by an injection of 15 mg/kg LPS 5 min later.The mice were sacrificed in 0,1,3,9 and 12 h after LPS injection.The wet/dry ratio(W/D) was recorded for pulmonary function and the pathological changes of lung tissues stained by HE were examined by light microscopy.The expression of NF-κB p65 was detected by Western blotting,and the levels of tumor necrosis factor-α(TNF-α) and interleukin-10(IL-10) were determined by ELISA.Results The significant increase of W/D was found after LPS injection in L group,which indicated the existence of pulmonary edema;while the W/D in B group was lower(P0.05 or P0.01).The pathological changes of inflammation,such as pulmonary hemorrhage and the inflammatory cells infiltration,were obvious in 2 groups,but that was better in B group.Moreover,the expression of NF-κB p65 displayed double peak at 1 h and 9 h in L group,while there was only one at 9 h in B group.What's more,the value in B group decreased in comparison with L group(P0.05) except for the value at 9 h.At last,the level of TNF-α in B group was lower than in L group,but there was no difference of IL-10 between 2 groups.Conclusion BN52021 can induce the inflammation of acute lung injury induced by LPS via inhibiting the early activation of NF-κB.
【CateGory Index】: R285.5
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 2 Hits
1 Ni Zhiyu,Cong Bin,Dong Mei,Ma Chunling,Li Shujin,Wen Di,Xu Zhilu(Department of Forensic Medicine,Hebei Key Laboratory of Forensic Medicine,College of Basic Medicine,Hebei Medical University,Shijiazhuang,Hebei Province,050017,China);Effect of cholecystokinin octapeptide on IL-1β,IL-6 and IL-10 expression in LPS-induced RAW 264.7 cells[J];Journal of Third Military Medical University;2011-22
2 Zhou haiqiang,Dai yue Department of Pharmacology of Chinese Materia Medica,China Pharmaceutical University,Nanjing 210009,China;Research advances of active constituents of traditional Chinese medicines for treating acute lung injury[J];Chinese Journal of Ethnomedicine and Ethnopharmacy;2011-12
Chinese Journal Full-text Database 4 Hits
1 ZOU Xian-wei,WU Shan (Department of Neurology,Affiliated Hospital of Guiyang Medical College,Guiyang 550004,China);Expression of NF-κB in the brain and lung and its role in acute lung injury following intracerebral hemorrhage of rats[J];Acta Academiae Medicinae Militaris Tertiae;2007-19
2 HU Ming-dong1,XU Jian-cheng1,ZHOU Chang-xi1,YANG Yu1,QIAN Gui-sheng1,MAO Mei2(1Institute of Respiratory Diseases of PLA,Xinqiao Hospital,Third Military Medical University,Chongqing 400037;2Department of Respiratory Diseases,Wuhan General Hospital of Guangzhou Military Command,Wuhan 430061,China);Contrast investigation of rat acute lung injury induced by different doses of flagellin[J];Acta Academiae Medicinae Militaris Tertiae;2009-01
3 Guo Zhenghui,Hong Xin,Mao Baoling,et al.Department of Instisute of Respiratory Disease,Xingqiao Hospital,Third Military Medical University,Chongqing 400037,China [;Effects of nuclear factor-κB activation on acute lung injury[J];Journal of Emergency Medicine;2003-09
4 LU Guohua DAN Renfei ZHOU Jianying YAO Hangping. Department of Pulmonary Diseases,First Affiliated Hospital,Medical College Of Zhejiang University,Hangzhou 310003,China;Protective effect of Ginaton on lipopolysaccaride-induced acute lung injury in rats[J];Chinese Journal of Emergency Medicine;2006-08
Chinese Journal Full-text Database 10 Hits
1 CHEN Wei-dong1,2,3,LIANG Yan4,XIE Lin4,et al(1.Pharmacokinetic Laboratory in College of Pharmacy,Anhui University of Traditional Chinese Medicine,Hefei,Anhui 230031,China; 2.Anhui Province Engineering Research Center of Preparations,Hefei,Anhui 230022,China;3.Anhui Province Key Laboratory of R&D of Chinese Medicine,Hefei,Anhui 230022,China;4.Key Lab of Drug Metabolism and Pharmacokinetics,China Pharmaceutical University,Nanjing,Jiangsu 210038);Protein binding ratio of Ginkgolide B in plasma[J];Anhui Medical and Pharmaceutical Journal;2012-02
2 Deng Jia,Li Changyi,Wang Daoxin (Department of Respiratory Diseases,Second Affiliated Hospital,Chongqing Medical University,Chongqing,400010,China);Effect of ulinastatin on expression of ENaC-β mRNA and protein in A549 cells treated with TNF-α[J];Acta Academiae Medicinae Militaris Tertiae;2010-09
3 JIANG Jing-jing,SHI Xue-yin,YUAN Hong-bin,ZHU Qiu-feng,WANG Cheng-cai,SUN Hai-jing.Department of Anesthesiology,Changzheng Hospital,Second Military Medical University,Shanghai 200003,China;Effects of ulinastatin on NF-κB expression in lung tissue of rats with acute lung injury[J];Medical Journal of Chinese People's Liberation Army;2009-05
4 GONG Xiaohui, HU Xiaowei, SUN Bo. Laboratory of Pediatric Respiratory and critical Care Medicine, Children's Hospital of Fudan University, Shanghai 200032, China;Effects of inhaled nitric oxide on denovo synthesis of phosphatidylcholine in adult rat lungs with endotoxin-induced inflammatory injury[J];Journal of Emergency Medicine;2004-06
5 ZHANG Hong SUN Geng-yun~*.* Respiratory Department,The First Affiliated Hospital of Anhui Medical University,Hefei 230022,China;Protective effects of angiotensin Ⅱ receptors antagonist on the LPS-induced lung acute injury[J];Chinese Journal of Emergency Medicine;2007-09
6 JIE Xiang,CHEN Min-hui,FU Zhi-ping,XU Jun(Guangzhou Institute of Respiratory Diseases,The First Affiliated Hospital of Guangzhou Medical College,Guangzhou 510120,Guangdong,China);Research on Mechanism of Tianlong Kechuanling Treating Virus-induced Acute Lung Injury[J];Liaoning Journal of Traditional Chinese Medicine;2012-11
7 WANG Hai-yun*,SHENG Jing,ZHU Jian(*Department of Emergency,the 9th People's Hospital Affiliated to Shanghai Jiaotong University School of Medicine,Shanghai 200011,China);Effect of fasudil on activation of nuclear factor-kappa B in lung tissue of lipopolysaccharide-induced acute lung injury rats[J];Journal of Chinese Practical Diagnosis and Therapy;2013-02
8 LI Yuan-yuan,LIU Hong,LI Fang-fang(ICU,First Clinical Medical College,Shanxi Medical University,Taiyuan 030001,China);Influence of ulinastatin on nuclear factor-κB (NF-κB) expression in rats with lipopolysaccharide-induced acute kidney injury[J];Journal of Shanxi Medical University;2008-03
9 DU Li-na,SHAN Jin-jun,WANG Shou-chuan Nanjing University of Traditional Chinese Medicine,Jiangsu;Advances in application of quercetin for respiratory system diseases[J];Shanghai Journal of Traditional Chinese Medicine;2012-08
10 PAN Jian,YUAN Yuan,WU Ze-yu,HUI Ai-ling(Institute of Natural Medicine Engineering Research,Center of Bio-process,Ministry of Education,Hefei University of Technology,Hefei 230009,China);LC-MS/MS Method for the Determination of Ginkgolide B in Rat Plasma[J];Lishizhen Medicine and Materia Medica Research;2012-08
Chinese Journal Full-text Database 10 Hits
1 Cai Wanru, Hong Huihua, Luo Xianfang, et al First Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou(310006);Effect of Qidong Huoxue Decoction on Rats’ ET-1 with Acute Lung Injury Caused by Oleic Acid[J];Journal of Zhejiang University of Traditional Chinese Medicine;2008-02
2 CAI Wan-ru,HONG Hui-hua,LUO Xian-fang,ZHANG Hong,WANG Xin-hua(The First Affiliated Hospital of Zhejiang University of Traditional Chinese Medicine,Hangzhou 310006,China);Experimental study of Qidonghuoxueyin on acute lung injury in rats[J];China Journal of Traditional Chinese Medicine and Pharmacy;2008-09
3 PEI Ling-peng,CUI Jian (Central University for Nationalities, Institute of Minarity Traditional Medicine Research, Beijing 100081, China);Study on protective effects of canthaxanthin on immuno-function of acute lung injury mouse model induced by lipopolysaccharide[J];China Journal of Traditional Chinese Medicine and Pharmacy;2009-04
4 YANG Ce,CHEN Yong-hua,HUANG Hong,WANG Hai-yan,XIE Guo-qi,JIANG Jian-xin(State Key Laboratory of Trauma,Burns and Combined Injury,Department 4,Institute of Surgery Research,Daping Hospital,Third Military Medical University,Chongqing 400042,China);Expression of pattern recognition receptors on macrophages,their interaction and relationship with develop ment of inflammatory response in traumatic infection[J];Acta Academiae Medicinae Militaris Tertiae;2009-15
5 WANG Wu-chao,CHEN Jin-ping,ZHANG Xiu-zhu,DAI Wei,LIU Da-wei,ZHOU Ji-hong(State Key Laboratory of Trauma,Burns and Combined Injury,Department 4,Institute of Surgery Research,Daping Hospital,Third Military Medical University, Chongqing 400042,China);Effects of corticotrophin-releasing hormone on IL-10 secretion from peritoneal macrophages and its signal mechanism[J];Acta Academiae Medicinae Militaris Tertiae;2009-22
6 Wang Yanyan,Liu Xin,Cao Hongwei,Wang Ning,Lu Yongling,Zheng Jiang (Medical Research Centre,Southwest Hospital,Third Military Medical University,Chongqing,400038,China);Inhibition of chloroquine on TLR4-MyD88-independent signaling pathway in lipopolysaccharide/endotoxin-induced RAW264.7 cells[J];Acta Academiae Medicinae Militaris Tertiae;2010-09
7 LI Chun sheng, GUI Pei chun, HE Xin hua (General Hospital of Beijing Command, Beijing 100700, China);Protective effect of Rhubarb to acute lung injury induced by endotoxin in rats[J];Basic Medical Sciences and Clinics;2001-01
8 NI Zhi-yu, LI Shu-jin, CONG Bin, YAO Yu-xia, WANG Chun-yan(The School of Basic Medical Sciences,Hebei Medical University,Shijiazhuang 050017,China);Inhibitory effect of CCK-8 on the expressions of TLR4 and IL-1β in LPS-induced pulmonary interstitial macrophages of rats[J];Basic Medical Sciences and Clinics;2005-02
9 LI Wei-wei,CHEN Jie,WANG Xiang-rui.Department of Anesthesiology,Renji Hospital,School of Medicine,Shanghai Jiaotong University,Shanghai 200127, China;Protective effects of glycyrrhizin on sepsis-induced acute lung injury in rats[J];The Journal of Clinical Anesthesiology;2009-09
10 LIN Bo~1,ZHANG Yunyi~1,XU Han~2,CHEN Daofeng~2(1 Department of Pharmacology,2 Department of Pharmacognosy, School of Pharmacy,Fudan University,Shanghai 200032,China);Anti-oxidative effect of the Bupleurum polysaccharides in treating acute lung injury of rats[J];Chinese Journal of Clinical Pharmacy;2010-01
【Secondary References】
Chinese Journal Full-text Database 1 Hits
1 ZHANG Tian-Jie 1,2 , HAN Jian-Zhong 1 , LIU Hui-Jun 1 , LIAO Xiao-Hong 1 , LI Chen 1,3,* , LUO Zi-Qiang 1,* 1 Department of Physiology, Central South University, Changsha 410078, China; 2 Department of Physiology, Xiangnan College, Chenzhou 423000, China; 3 Department of Physiology, Changzhi Medical College, Changzhi 046000, China;Role of uteroglobin-binding protein in antiflammin-1 promoting IL-10 expression and secretion in RAW264.7 cells induced by endotoxin[J];Acta Physiologica Sinica;2013-04
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 LI Qi, QIAN Gui sheng, ZHANG Qing, WANG Chang zheng (Institute of Respiratory Diseases, Xingqiao Hospital, Third Military Medical University, Chongqing 400037, China);Effects of different doses of lipopolysaccharide on acute lung injury in rats[J];Acta Academiae Medicinae Militaris Tertiae;2004-10
2 HU Ming-dong, XU Jian-cheng, FENG Ying-kai,ZHOU Chang-xi, GONG Chuan-ming (Institute of Respiratory Diseases, Xinqiao Hospital, Third Military Medical University, Chongqing 40037,China);Isolation and purification of flagellin from Salmonella paratyphi A and preparation of its specific antiserum[J];Acta Academiae Medicinae Militaris Tertiae;2005-07
3 CHEN Xiaodong, WANG Shunbin, JIANG Qiong, et al. Provincial Burns Institute, Union Hospital, Fujian Medical University, Fuzhou 350001, China;The effect of endotoxins on the levels of cytokines,soluble adhesion molecule,and sFas/sFasL in patients with severe burn[J];Journal of Emergency Medicine;2004-07
4 LI Li,FANG Qiang,HE Feifang.Intensive Care Unit, The First Affiliated Hospital, Medical College, Zhejiang University, Hangzhou 310003, China;Modulatory effects of prostaglandin E1 on expression of NF-κB in acute lung injury[J];Chinese Journal of Emergency Medicine;2006-04
5 ZHANG Zhi Xiong 1,* , QI Xiao Yan 1, XU You Qiu 2 1Department of Physiology, Shanghai University of Traditional Chinese Medicine, Shanghai 200032; 2Department of Physiology, Shanghai Second Medicial University, Shanghai 200025;Effect of ginkgolide B on L-type calcium current and cytosolic [Ca~(2+)]_i in guinea pig ischemic ventricular myocytes[J];Acta Physiological Sinica;2003-01
6 Xia Shihai,Zhao Xiaoyan,Guo Ping,Zhang Weilong,Ren Wanying,and Wang Suli.Department of Gastroenterology,Affiliated Hospital,Medical College of Chinese People's Armed Police Forces,Tianjin 300162,China;Dynamic changes of plasma endotoxin and inflammatory mediators in dogs with severe acute pancreatitis and intervention with platelet activating factor receptor antagonist[J];Medical Journal of the Chinese People's Armed Police Forces;2002-10
7 WANG Xing-Peng;YUAN Yao-Zong;XU Jia-Yu(Dept of Gastroenterology,Ruijin Hospital,ShanghaiSecond Medical University,Shanghai 200025);The therapeutic effect of Ginkgolides on acute pancreatitis in rats and its mechanisms[J];CHINESE PHARMACOLOGICAL BULLETIN;1995-03
8 NIE Zhen gui, WANG Wen jie (Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China);Effect of ginkgolide B on platelet-activating factor induced activation of rat polymorphonuclear leukocytes[J];Acta Pharmaceutica Sinica;2003-02
9 Wang Xing-Peng;Xu Jia-Yu;et al(Ruijin Hospital,Shanghai Second Medical University,Shanghai);Pathogenetic roles of platelet-activating factor in acute pancreatitis-associated lung injury in rats[J];CHINESE JOURNAL OF PATHOPHYSIOLOGY;1994-06
10 SUN Ying *,SUN Ren-yu,DU Ye-wei, WANG Shi-wen. *Institute of Basic Medical Sciences, CAMS & PUMC, Beijing 100005, China;Protective effect of Ginkgo biloba extract on acute lung injury in aging rats and renal function damage induced by acute lung injury[J];Chinese Journal of Geriatrics;2004-05
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved