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《Acta Academiae Medicinae Militaris Tertiae》 2009-15
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Extraintestinal lesions caused by rotavirus:An experimental study on suckling mice

CHEN Jun-hua,XIE Yuan-yuan,ZHU Chao-min,LIU Zuo-yi(Department of Infectious Disease,Children's Hospital,Chongqing Medical University,Chongqing 400014,China)  
Objective To study the extraintestinal lesions induced by rotavirus(RV)infection and explore the pathogenesis.Methods Simian rotavirus SA11 was cultured in MA-104 cells.After inoculation,the pathological changes in brain,lung,heart,liver,pancreas and kidney tissues were observed,the RV antigens detected,and the apoptotic cells observed.Besides,we stained the filamentous actin(F-actin)with Phalloidine-TRITC,and then quantified the F-actin amount.Results Several pathological changes,inclusive of myocardial interstitial edema,granular degeneration in cardiacytes,hepatic congestion,and hepatocellular vacuolar degeneration,were found,but not found in the brain,lung,and pancreas tissues.Meanwhile,several ultrastructural changes,inclusive of dissolved myocardial F-actin,extended smooth endoplasmic reticulum,swollen mitochondria,and widened perinuclear space,were found.No difference was found in the quantity of myocardial F-actin.Apoptosis was found in liver cells,but not in myocardial cells.RV RNA was detected in tissues such as brain,lung,heart,liver and pancreas tissues.Conclusion All the results suggest that RV may spread from the intestine to various extraintestinal organs and hence induce injury.Filamentous actin depolymerization,cytoskeleton damage and apoptosis induced by RV infection are the important mechanism not only in intestinal damages,but also in extraintestinal lesions.
【CateGory Index】: R725.1
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Chinese Journal Full-text Database 4 Hits
1 CHEN Jun-hua1,XIE Yuan-yuan1,LING Hua2,LIU Zuo-yi1(Department of Infection and Gastroenterology,Children's Hospital,Chongqing Medical University,Chongqing 400014;Chongqing Center for Disease Control and Prevention,Chongqing 400042,China);On pathogenesis of rotavirus diarrhea in suckling mouse[J];Acta Academiae Medicinae Militaris Tertiae;2007-12
2 YAO Ying-min1, OU Qiao-qun1, CHEN Yao2 Department of Pediatrics, Nanfang Hospital1, School of Biotechnology2, Southern Medical University, Guangzhou 510515, China;Ultrastructural changes of the extraintestinal organs of newborn mice with human rotavirus infection[J];Journal of Southern Medical University;2006-09
3 HUANG Xiao-lei,CHEN Jie,YU Yan-ping,et al(The Affiliated Children's Hospital,College of Medicine,Zhejiang University,Hangzhou 310003,China);Viraemia and extraintestinal involvement after rotavirus infection[J];Journal of Zhejiang University(Medical Sciences);2006-01
4 YAO Ying-min, OU Qiao-qun, CHEN Yao (Department of Pediatrics,Nanfang Hospital,Southern Medical University, Guangzhou,510515 , China );Pathological changes of extra-intestinal infection in newborn mice infected with human rotavirus[J];Chinese Journal of Zoonoses;2006-07
Chinese Journal Full-text Database 10 Hits
1 CHEN Chao1,2,GAO Hong2,ZHAO Bao-hong2,QU Chang-lin2 (1.Ruili Drug Detector Dog Base of China Custom,Ruili,Yunnan,678600,China;2.College of Animal Science and Technologe,Yunnan Agriculture University,Kunming,Yunnan,650201,China);In-situ PCR and Its Application in Pathology[J];Progress in Veterinary Medicine;2007-05
2 ;Rotavirus Gastroenteritis Accompanied by Damage of Central Nervous System[J];International Journal of Pediatrics;2007-04
3 SHI Hai-fan,LI Meng-rong,CHEN Yi-ping,et al.(The 2nd Affiliated Hospital,Yuying Children's Hospital of Wenzhou Medical College,Whenzhou Zhe jiang 325027,China);Study of the damage by human rotavirus in suckling mouse and the protection of Lactobacillus acidophilus[J];Strait Pharmaceutical Journal;2010-05
4 YIN Jian,PENG Zhi-pei,TEN Jiu-xiang,WU Shen-rong,ZHANG Guo-ming,WANG Li,TANG Xi(TCM University of Hunan,Changsha,Hunan 410007,China);Effects of Qinxiang granules on IFN-γ in suckling mice Infected by human rotavirus[J];Journal of Traditional Chinese Medicine University of Hunan;2010-01
5 ZHANG Sheng,ZHOU Tao,FU Si-mao,et al.Department of Pediatrics,Zhongshan Boai Hospital Affiliated to Nanfang Medical University,Zhongshan 528403,China;Siginificance of Detection of Serum and CSF Interleukin in Children with Rotavirus Enteritis Combined with Benign Convulsions[J];Chinese General Practice;2010-32
6 Yuan Baoli Xiong Wei Department of Pediatrics,the Second Affiliated Hospital of Guangzhou Medical College (Guangzhou 510260);A Clinical Study of Extraintestinal Involvement after Rotavirus Enteritis in 65 Infants[J];Shaanxi Medical Journal;2008-01
7 LIU Ting-ting,CHEN Lei,ZHOU Rui,et al.Department of Pediatrics,the First Affiliated Hospital of Bengbu Medical College,Bengbu 233004,Anhui,China;Analysis of Index of Myocardial Injury Caused by Rotavirus Enteritis in Infants[J];Chinese Journal of General Practice;2011-01
8 SHI Pin-ying,CHENG Hua,SHEN Ming.Department of Pediatrics,Nantong Hospital of Traditional Chinese Medicine,Nantong 226001,Jiangsu,China;Clinical Study on 12 Cases of Rotavirus Gastroenteritis with Benign Convulsions in Children[J];Chinese Journal of General Practice;2011-10
9 ZHANG Li-xia1,LV Chun-yan2.1.The Second People's Hospital of Shuangliu,Shuangliu,Sichuan,610213;2.The Affiliated Hospital of Chengdu Tranditional Medicine University,Chengdu,Sichuan 610072,China;Curative effect of zine glycyrrhizate in treating the rotavirus infectious enteritis in chidren[J];Sichuan Medical Journal;2011-10
10 XU Zhi-wei,LI Meng-rong,CHEN Yi-ping,SHI Hai-fan,DI Jun-bo Department of Infection,Yuying Children′s Hospital Affiliated to Wenzhou Medical College,Wenzhou 325027,Zhejiang,China;Protection of CpG oligodeoxynucleotide on human rotavirus-induced diarrhea in suckling mouse model[J];Chinese Journal of Clinical Pharmacology and Therapeutics;2008-09
【Secondary Citations】
Chinese Journal Full-text Database 8 Hits
1 Hong LAI, Cheng-Ning ZHENGDepartment of Pediatrics, Sino-Japan Friendship Hospital, Beijing 100029, China;Clinical features of benign infantile convulsions associated with mild gastroenteritis[J];The Chinese Journal of Contemporary Pediatrics;2005-04
2 LI Ning 1, YAO Ying Min 1,WANG Zhi Rui 2 1Department of Pediatrics, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China; 2Department of Pharmacon, Xijing Hospital, Fourth Military Medical University;Co-relative factors between heart lesion and viremia in young children with rotavirus diarrhea[J];Journal of The Fourth Military Medical University;2001-08
3 LI Ning, YAO Ying-min, Wen Shu-juan (Department of Paediatrics, Department of Endocrinology, Nanfang Hospital, First Militia Medical University, Guangzhou 510515, China);Viremia in infants with rotavirus diarrhea: a preliminary study[J];Journal of First Military Medical University;2001-04
4 YAO Ying-min, OU Qiao-qun, LI NingDepartment of Pediatrics, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China;Extraintestinal dissemination of rotavirus in immunodeficient mice[J];Journal of First Military Medical University;2004-11
5 Li Yongfang Wang Yukun Gu Baoliang Department of Microbiology;CELL CULTURE AND GENOMIC ANALYSIS OF REASSORTANTS OF ROTAVIRUSES[J];;1992-01
6 LI Ning, YAO Yingmin. Department of Pediatrics,Nanfang Hospital, the First Military Medical University, Guangzhou 510515, China;Multi-system rotavirus infection in 2 infants[J];Chinexe Journal of Pediatrics;2002-03
7 ZHOU Zuiming,LIANG Qiaoming,DU Jiang,WU Miaoling (Central laboratory of Zhujiang Hospital, First Military Medical University,Guangzhou 510282);THE STUDY OF VIRUSEMIA IN CHILDHOOD PATIENTS WITH ACUTE ROTOVIRUS INFECTIOUS DIARRHEA[J];Chinese Journal of Zoonoses;2001-01
8 GONG Si tang,XIAO Zuo yuan,CHEN Hui qin,et al (Guangzhou Children's Hospital,Guangzhou 510120);Clinical Study of Infantile Rotavirus Enteritis Complicated with Multiple Organ Injury[J];Chinese Journal of Misdiagnostics;2001-02
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