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《Acta Academiae Medicinae Militaris Tertiae》 2009-21
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Flow-sensitive alternating inversion recovery and dynamic susceptibility contrast MR perfusion imaging for brain tumors: a comparative study of 35 cases

WU Xue-bin,ZHANG Wei-guo,CHEN Jin-hua,ZOU Bo,MA Chang-suo ( Department of Radiology,Institute of Surgery Research,Daping Hospital,Third Military Medical University,Chongqing 400042,China)  
Objective To evaluate the application of flow-sensitive alternating inversion recovery ( FAIR) of MR perfusion technique in the clinical diagnosis of intracranial tumors compared with the technique of dynamic susceptibility contrast ( DSC) MR perfusion. Methods All patients ( 35 patients with intracranial tumors first discovered) underwent the FAIR and DSC-MR perfusion imaging subsequently after the conventional sequences. The ratios of relative tumor blood flow ( rTBF) were computed for the same region of interest within tumor by the 2 techniques above and the results were analyzed by correlation analysis. Additionally,we have compared the results of the maximum relative tumor blood flow ( rTBFmax) and maximum relative tumor blood volume ( rTBVmax) between intra-axial benign and extra-axial groups,intra-axial malignant and extra-axial, benign and malignant of intra-axial tumors. Results It was coincidence for the regional cerebral blood flow maps by the 2 methods and linear correlation of the ratios of relative tumor blood flow in the same region of interest ( r = 0. 667,P = 0. 000) . There were statistical differences of the rTBFmax of FAIR MR perfusion in between intra-axial benign and extra-axial benign group,between intra-axial benign and intra-axial malignant group. So was the rTBVmax of DSC MR perfusion. There was no statistical difference of the 2 values between intra-malignant and extra-axial groups. Conclusion As an absolute noninvasive and repeatable technique and with no contrast agents needed,FAIR,has a widely potential in clinical application. Since offering the hemodynamic information as the DSC-MR perfusion imaging coincidently.
【Fund】: 重庆市科技攻关项目(CSTC2007AC5014)~~
【CateGory Index】: R739.41
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